Preparation method of urethral stent and urethral stent

Abstract

The invention provides a preparation method of a urethral stent and the urethral stent. The preparation method comprises the following steps: preparing a PLLA membrane with good toughness and good mechanical strength from lecithin and PLLA, putting a first PLLA stent into an alkaline solution to modify the first PLLA stent so as to activate carboxyl on a surface of the first PLLA stent to obtain a second PLLA stent, firstly reacting the second PLLA stent with EDC to generate an intermediate product, then reacting with NHS to form a group easy to bind to amino to obtain a third PLLA stent, covalently grafingchitosan on a surface of the third PLLA stent to obtain a fourth PLLA stent, and then binding individual molecules of chitosan into a network structure through a surface cross-linking agent to obtain the urethral stent. Due to a fact that chitosan molecules are only distributed on a surface of the third PLLA stent, the prepared urethral stent is not compact and crisp, has good mechanical properties, and can prevent disintegration and fragmentation from blocking the urethra.

Description

technical field

[0001] The invention relates to the technical field of medical devices, in particular to a preparation method of a urethral stent and the urethral stent. Background technique

[0002] Urethral stenting has been greatly developed in my country in recent years. At present, the commonly used clinical method is to place a urethral stent at the urethral stenosis to open the urethral stenosis or obstruction, which can restore the voiding function of most patients with dysuria after placing the urethral stent.

[0003] At present, in clinical practice, urethral stents are prepared using L-polylactic acid (PLLA). , non-irritating, biodegradable and absorbable. However, the existing urethral stents are dense and brittle, have poor mechanical properties, and are easy to disintegrate and fragment, thereby forming a large number of fragments to block the urethra. Contents of the invention

[0004] The object of the present invention is to provide a method for pr...

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