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Preparation method of urethral stent and urethral stent

A urethra and mixed solution technology, applied in the field of medical devices, can solve problems such as easy disintegration and fragmentation

Active Publication Date: 2022-01-04
BEIJING INSTITUTE OF GRAPHIC COMMUNICATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to propose a method for preparing a urethral stent and the urethral stent to solve the problem that the existing urethral stent is dense and brittle, and is easy to disintegrate and fragment

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  • Preparation method of urethral stent and urethral stent

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preparation example Construction

[0034] It is well known that chitosan has good solubility only in acetic acid solution. However, PLLA is insoluble in acetic acid, so chitosan and PLLA do not have a common good solvent. The inventors tried to dissolve PLLA in chloroform and chitosan in acetic acid respectively, mix and stir, and pour the mold after 48 hours. However, because the volatility of chloroform is much greater than that of acetic acid, the resulting finished products failed to form a film. Although it has been reported that poly-L-lactide / chitosan membranes choose a solvent system consisting of acetic acid and dimethyl sulfoxide. Certain processing parameters, such as the concentrations of the component solutions and the composition ratios of the mixed solvent and the extraction solvent, were optimized by mainly considering whether a directly visible phase separation occurred during the processing, and finally the membrane was prepared. Alternatively, use solution precipitation and glutaraldehyde cr...

Embodiment 1

[0071] Step 1, dissolving lecithin and PLLA in chloroform to form the first mixed solution, the mass ratio of the lecithin and the PLLA is 5: 100, stirring the first mixed solution in a constant temperature water bath at 25°C for 48h, Then pour the suspension in a volume of 10ml / cm² into a glass or polytetrafluoroethylene mold to volatilize to form a film. The ambient temperature is 23°C and the relative humidity is 20%. After the film was dried, it was taken out and cut into long strips with a width of 4 mm. After the long strip is shaped into a ridge shape, it is wound into a spiral shape on a glass rod. Put it in a vacuum oven and dry at 37°C for 14 days to prepare the first PLLA scaffold;

[0072] Step 2. Wash the first PLLA stent prepared in step 1 three times in methanol aqueous solution (methanol / water = 1:1) within 25 minutes, dry it in vacuum at 30°C for 24 hours, and then place the dried first PLLA stent into a NaOH solution at a temperature of 58° C. for 30 minute...

Embodiment 2

[0079]Step 1, dissolving lecithin and PLLA in chloroform to form the first mixed solution, the mass ratio of the lecithin and the PLLA is 1: 100, stirring the first mixed solution in a constant temperature water bath at 40°C for 48h, Then pour the suspension in a volume of 10ml / cm² into a glass or polytetrafluoroethylene mold to volatilize to form a film. The ambient temperature is 23°C and the relative humidity is 20%. After the film was dried, it was taken out and cut into long strips with a width of 4 mm. After the long strip is shaped into a ridge shape, it is wound into a spiral shape on a glass rod. Put it in a vacuum oven and dry at 37°C for 14 days to prepare the first PLLA scaffold;

[0080] Step 2. Wash the first PLLA stent prepared in step 1 three times in methanol aqueous solution (methanol / water = 1:1) within 25 minutes, dry it in vacuum at 30°C for 24 hours, and then place the dried first PLLA stent into a KOH solution at a temperature of 58° C. for 30 minutes ...

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Abstract

The invention provides a preparation method of a urethral stent and the urethral stent. The preparation method comprises the following steps: preparing a PLLA membrane with good toughness and good mechanical strength from lecithin and PLLA, putting a first PLLA stent into an alkaline solution to modify the first PLLA stent so as to activate carboxyl on a surface of the first PLLA stent to obtain a second PLLA stent, firstly reacting the second PLLA stent with EDC to generate an intermediate product, then reacting with NHS to form a group easy to bind to amino to obtain a third PLLA stent, covalently grafingchitosan on a surface of the third PLLA stent to obtain a fourth PLLA stent, and then binding individual molecules of chitosan into a network structure through a surface cross-linking agent to obtain the urethral stent. Due to a fact that chitosan molecules are only distributed on a surface of the third PLLA stent, the prepared urethral stent is not compact and crisp, has good mechanical properties, and can prevent disintegration and fragmentation from blocking the urethra.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a preparation method of a urethral stent and the urethral stent. Background technique [0002] Urethral stenting has been greatly developed in my country in recent years. At present, the commonly used clinical method is to place a urethral stent at the urethral stenosis to open the urethral stenosis or obstruction, which can restore the voiding function of most patients with dysuria after placing the urethral stent. [0003] At present, in clinical practice, urethral stents are prepared using L-polylactic acid (PLLA). , non-irritating, biodegradable and absorbable. However, the existing urethral stents are dense and brittle, have poor mechanical properties, and are easy to disintegrate and fragment, thereby forming a large number of fragments to block the urethra. Contents of the invention [0004] The object of the present invention is to provide a method for pr...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/04A61L31/14A61L31/16
CPCA61L31/06A61L31/042A61L31/14A61L31/16A61L31/148A61L2400/18A61L2300/232A61L2300/404C08L67/04C08L5/08
Inventor 胡堃王海波郭林鑫峥韩璐李路海危岩
Owner BEIJING INSTITUTE OF GRAPHIC COMMUNICATION
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