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Absorbable tubular stent and preparation method and application thereof

A tubular, tube-walled technology, applied in the field of tubular stent materials and their preparation, and tubular stent materials, to achieve good mechanical strength, broad market prospects, and good blood flow

Inactive Publication Date: 2016-01-06
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polylactic acid chemical polymer materials can be degraded and absorbed in the body, but the acidic degradation products produced by the degradation in the tissue will cause a certain aseptic inflammatory response

Method used

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  • Absorbable tubular stent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of acylated chitosan

[0017] (1) Preparation of acylated chitosan 1: Weigh 20 g of chitosan powder (deacetylation degree 90.4%, molar percentage, the same below), add it to a glass reaction vessel, add 50 mL of acylating reagent acetic anhydride solution, add methanol 100ml, control the temperature at 10°C, add 1ml of perchloric acid solution with a concentration of 70% by weight under stirring as a catalyst, and stir for 18 hours. After the reaction is completed, filter and separate the solid and liquid, put the solid into 5% NaOH aqueous solution by weight, neutralize the acid and alkali, centrifuge, separate the solid and liquid, wash the solid with water to remove the salt, 95% ethanol (weight percentage , the same below) dehydration, heating and drying at 60°C to obtain acylated chitosan 1 with a degree of acylation of 72.5% (mole percentage, elemental analysis, the same below). Acylated chitosan 1 has an acetyl structure with an ac...

Embodiment 2

[0027] Example 2: Cytocompatibility and degradation absorption of acylated chitosan

[0028] Preparation of acylated chitosan diaphragm: Take 2 g of acylated chitosan powder with a degree of acetylation of 85%, add 100 ml of formic acid solution with a concentration of 80% by weight, stir and dissolve, and prepare a mixture with a weight-to-volume ratio of 2 % acylated chitosan glue. Measure 15ml of the acylated chitosan glue respectively, place them in a PP square plate with a side length of 50mm×50mm, and let it stand and dry in a fume hood. The dried membrane is placed in 2% NaOH aqueous solution for acid-base neutralization, washed with water until the pH is neutral, and dried to prepare the acylated chitosan membrane.

[0029] An acylated chitosan membrane with a diameter of 7 mm was prepared with a trephine, placed at the bottom of a 96-well cell culture plate, and fully infiltrated with DMEM medium plus 10% newborn bovine serum for 24 hours. Take the L929 cells in t...

Embodiment 3

[0033] Example 3: Preparation of Absorbable Tubular Material 1

[0034] Weigh 1.0 g of polylactic acid (molecular weight: 20,000), stir and dissolve in 50 ml of dimethylformamide (DMF), add 1.0 g of acylated chitosan 1 prepared in Example 2, stir and dissolve to obtain polylactic acid-acylated shell polysaccharide glue. Take a stainless steel rod pipe-making mold with a length of 10cm and a diameter of 6mm, connect it to the pipe-making mold interface on the pipe-making machine, turn on the pipe-making machine, rotate the stainless steel rod in the axial direction, and evenly mix the polylactic acid-acylated chitosan glue The ground coating is on the surface of the rotating stainless steel rod. With the volatilization of the solvent, continue to coat the polylactic acid-acylated chitosan glue, and spin dry at room temperature to obtain a tubular material with a tube wall thickness of 0.8 mm to 1 mm. Remove the stainless steel rod with the tubular material, soak it in hot wa...

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Abstract

The invention discloses an absorbable tubular stent. The absorbable tubular stent is characterized in that the tubular stent is made by blending of polylactic acid and acylated chitosan, and the wall of the tubular stent is provided with or without a porous structure or pattern structure. Due to addition of the acylated chitosan, local acidity generated by the polylactic acid in degradation can be regulated, and oligosaccharides and monosaccharide obtained by degradation of the acylated chitosan can be absorbed and used by organisms, so that high biocompatibility, degradability and absorbability are achieved; the tubular stent has excellent mechanical strength and press resilience. The absorbable tubular stent can be planted in vivo by surgeries to serve as an intravascular stent and is applicable to treatment of embolism or blood vessel lumina narrowing caused by vascular diseases; the absorbable tubular stent can also serve as a biliary stent to be applied to treatment of cholestasis and pancreaticobiliary obstruction caused by pancreatobiliary neoplasms; the absorbable tubular stent can further serve as a urethral stent to be applied to treatment of dysuria resulted from urethral compression caused by prostatic hyperplasia. The absorbable tubular stent can be degraded and absorbed in vivo finally along with lesion repair, in-vivo long-term retention is avoided, and the absorbable tubular stent has a promising market prospect.

Description

technical field [0001] The invention relates to a tubular stent material, in particular to a degradable and absorbable tubular stent material and its preparation method and application, belonging to the field of biomedical materials. Background technique [0002] Tubular stents have a wide range of clinical uses, and can be used for esophageal stents, blood vessel stents, bile duct stents, urethral stents, etc. Vascular stents are implantable medical device products used for the treatment of vascular lumen stenosis or embolization caused by vascular diseases, to "stretch" the narrowed blood vessels, increase blood flow and prevent myocardial infarction. Bile duct stent is used for the treatment of pancreaticobiliary duct obstruction and cholestasis caused by pancreaticobiliary malignant tumors. Urethral stents are used to treat urethral strictures that make it difficult to pass urine due to enlarged prostate glands that compress the urethra. Among vascular stents, bile duc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/14
Inventor 韩宝芹彭燕飞杨艳常菁
Owner OCEAN UNIV OF CHINA
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