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Urethral stent and preparation method and application thereof

A urethral and joint technology, applied in the field of urethral stent and its preparation, can solve the problems of repairing or treating damage, increasing economic burden, urethral stricture, etc.

Pending Publication Date: 2020-10-30
YIPURUN SHANGHAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the catheters on the market are only used for physical support and drainage, and do not repair or treat the damage. After the catheter is implanted, it may stimulate the body to cause inflammation, and scar tissue will form at the damaged site, resulting in urethral restenosis
For restenosis of the urethra, repeated operations may easily cause other complications, which not only bring great physical and mental pain to the patient, but also increase the financial burden

Method used

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  • Urethral stent and preparation method and application thereof
  • Urethral stent and preparation method and application thereof
  • Urethral stent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] This embodiment provides a urethral stent, comprising a stent matrix and a drug film arranged on the outer surface of the stent matrix, wherein the thickness of the drug film is 0.05mm; the stent matrix is ​​a stent matrix with a balloon of 8F polyurethane material (such as figure 1 shown), the sectional view of the stent matrix along A-A is as figure 2 shown.

[0078] This embodiment provides a method for preparing a urethral stent, comprising the following steps:

[0079] (1) Preparation of drug film solution: 78 parts by weight of one-component HTV silicone rubber, 20 parts by weight of dexamethasone (particle size is 1000 mesh), 1 part by weight of hydrogen-containing silicone oil and 1 part by weight of platinum catalyst are dissolved in 200 parts by weight Parts of n-hexane, mixed and stirred evenly to obtain the film liquid;

[0080] (2) Preparation of urethral stent: Take the stent matrix with a balloon of 8F polyurethane material, apply a 100 mm length of dr...

Embodiment 2

[0095] This embodiment provides a urethral stent, comprising a stent base and a drug film arranged on the outer surface of the stent base, wherein the thickness of the drug film is 0.5mm; the stent base is a single-lumen urinary catheter (model 8F) made of silicone rubber .

[0096] This embodiment provides a method for preparing a urethral stent, comprising the following steps:

[0097] (1) Preparation of drug film solution: Mix 60 parts by weight of single-component HTV liquid silicone rubber, 20 parts by weight of mometasone furoate (particle size is 3000 mesh), 0.2 parts by weight of hydrogen-containing silicone oil and 0.2 parts by weight of platinum catalyst, Obtain the drug film liquid;

[0098] (2) Preparation of the urethral stent: take the stent matrix of 8F silicone rubber material, put the drug film liquid and the stent matrix in the mold, and cure the drug film on the stent matrix by heating and vulcanizing, and obtain the urethral stent after demolding .

[00...

Embodiment 3

[0103] This embodiment provides a urethral stent, comprising a stent base and a drug film disposed on the outer surface of the stent base, wherein the thickness of the drug film is 1mm; the stent base is a braided stent made of metal (type 8F).

[0104] This embodiment provides a method for preparing a urethral stent, comprising the following steps:

[0105] (1) Preparation of drug film solution: Mix 30 parts by weight of two-component room temperature vulcanizing liquid silicone rubber A, 10 parts by weight of mometasone furoate (with a particle size of 3000 mesh), and 0.1 part by weight of platinum catalyst to obtain drug film solution A; Mix 30 parts by weight of two-component room temperature vulcanizing liquid silicone rubber B, 10 parts by weight of mometasone furoate (with a particle size of 3000 mesh), and 0.1 part by weight of hydrogen-containing silicone oil to obtain the drug film solution B;

[0106] (2) Preparation of urethral stent: Take the stent matrix woven an...

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Abstract

The invention provides a urethral stent and a preparation method and an application thereof. The urethral stent comprises a stent base body and a medicine film arranged on the outer surface of the stent base body, and the medicine film comprises controlled release factors and medicine; when the urethral stent is implanted into the urethra, the stent base body plays a role in supporting and draining the urethra, the medicine film is used for preventing or reducing restenosis of the urethra, and the urethral stent has the treatment effect of being low in dosage and high in efficiency, and has the long medicine release period and the good slow release capacity. Besides, the urethral stent can play a targeting role, the situation that the liver needs to be metabolized firstly during oral administration is effectively avoided, the dosage is about 10% of that of an oral administration or injection mode, and the side effect of the medicine on the whole body is greatly reduced.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a urethral stent and a preparation method and application thereof. Background technique [0002] Urethral stricture is a common disease of the urinary system. In addition to congenital stricture, inflammation and injury are the main causes of urethral stricture. For example, common infectious urethral stricture caused by urethral lumen infection, various transurethral operations or inspections, etc. In addition, with the rapid development of industry and transportation, the cases of traumatic urethral strictures caused by pelvic fractures and straddle injuries have a greater tendency to increase. [0003] At present, the clinical treatment methods for urethral stricture include repeated dilatation, incision, anastomosis, dragging operation, replacement plastic surgery and other surgical methods. After the operation, the patient needs to implant a urinary catheter for support and drai...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61L31/02A61L31/06A61L31/08A61L31/10A61L31/14A61L31/16
CPCA61F2/82A61L31/06A61L31/08A61L31/10A61L31/088A61L31/022A61L31/14A61L31/16A61L2300/602A61L2300/416A61L2400/18A61L2420/02A61L2300/43A61L2420/04A61L2420/06A61L2420/08C08L75/04C08L83/04C08L39/06
Inventor 夏佩佩晏伟魏征
Owner YIPURUN SHANGHAI BIOTECH CO LTD
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