A kind of heart valve modified by hydrophilic composite network laminate and its preparation method

A composite network and heart valve technology, applied in coatings, pharmaceutical formulations, prostheses, etc., can solve the problems of biological valves prone to thrombus, early failure, calcification, etc., to reduce the formation of thrombus and calcified spots, and prevent calcification and early failure, prolonging the service life effect

Active Publication Date: 2020-09-08
JILIN VENUS HAOYUE MEDICAL LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at problems such as thrombus, calcification, obstruction or early failure of cross-linked biological valves, the present invention provides a heart valve modified by a hydrophilic composite network laminate and a preparation method thereof

Method used

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  • A kind of heart valve modified by hydrophilic composite network laminate and its preparation method
  • A kind of heart valve modified by hydrophilic composite network laminate and its preparation method
  • A kind of heart valve modified by hydrophilic composite network laminate and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0035] (1) Preparation of mixed dispersions of water-based polymers / hydrophilic inorganic nanoparticles in different proportions

[0036] Low molecular weight and low concentration polymer mixed dispersion (PVA+PEG+1:3 silica) A: the selected molecular weight is ~5*10 3 g / mol and ~1*10 4 PEG and PVA of g / mol were dissolved in water respectively to form a mixed solution, and further 50nm silicon dioxide was added to the solution in a ratio of 1:3 to prepare a mixed dispersion A, wherein the concentrations of PEG and PVA were both 0.1wt%, for later use ;

[0037] Low-molecular-weight high-concentration polymer mixed dispersion (PEG+PAA+1:3 silica) B: the selected molecular weight is ~5*10 3 g / mol and ~1*10 4 g / mol PEG and PAA were respectively dissolved in water to form a mixed solution, and silicon dioxide was further added to the solution at a ratio of 1:3 to prepare a mixed dispersion A: the concentrations of PEG and PVA were both 2.5wt% for later use;

[0038] High molec...

Embodiment 2

[0044] (1) Preparation of mixed dispersions of water-based polymers / hydrophilic inorganic nanoparticles in different proportions

[0045] Low molecular weight and low concentration polymer mixed dispersion (PVA+PEG+1:3 hydroxyapatite) A: the selected molecular weight is ~5*10 3 g / mol and ~1*10 4 The PEG and PVA of g / mol were respectively dissolved in water to form a mixed solution, and 50nm hydroxyapatite was further added to the solution in a ratio of 1:3 to prepare a mixed dispersion A, wherein the concentrations of PEG and PVA were both 0.1wt%, spare;

[0046] Low-molecular-weight high-concentration polymer mixed dispersion (PEG+PAA+1:3 hydroxyapatite) B: the selected molecular weight is ~5*10 3 g / mol and ~1*10 4 g / mol PEG and PAA were dissolved in water to form a mixed solution, and 50nm hydroxyapatite was further added to the solution at a ratio of 1:3 to prepare a mixed dispersion A: the concentrations of PEG and PVA were both 2.5wt%, spare;

[0047] High molecular ...

Embodiment 3

[0053] (1) Preparation of mixed dispersions of water-based polymers / hydrophilic inorganic nanoparticles in different proportions

[0054] Low molecular weight and low concentration polymer mixed dispersion (PVA+PEG+1:2.5 calcium silicate) A: the selected molecular weight is ~8*10 3 g / mol and ~5*10 3 PEG and PVA of g / mol were respectively dissolved in water to form a mixed solution, and further 200nm calcium silicate was added to the solution in a ratio of 1:2.5 to prepare a mixed dispersion A, wherein the concentrations of PEG and PVA were both 0.7wt%, for later use ;

[0055] Low-molecular-weight high-concentration polymer mixed dispersion (PAA+PEG+1:2.5 calcium silicate) B: The selected molecular weights are ~~8*10 3 g / mol and ~5*10 3 PEG and PAA of g / mol were dissolved in water respectively to form a mixed solution, and further 200nm calcium silicate was added to the solution at a ratio of 1:2.5 to prepare a mixed dispersion A: the concentrations of PEG and PVA were both...

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Abstract

The invention discloses a cardiac valve modified by laminating a hydrophilic compound network and a preparing method of the cardiac valve. According to the cardiac valve modified by laminating the hydrophilic compound network, the multi-layer compound network structure is constructed on the surface of the crosslinking-fixed homogeneous or heterogeneous biological valve through a layer-by-layer overlapping coating mode, the contact angel of the surface of the valve is 15-80 degrees, and the hydrophilic modified biological valve is obtained. According to the hydrophilic compound network laminating structure on the surface of the valve, the first layer is a low-molecular-weight water-based polymer and inorganic nanoparticle mixed crosslinked film layer, and the second layer, the third layer,the fourth layer and the fifth layer are high-molecular-weight water-based polymer and inorganic nanoparticle mixed crosslinked film layers. The cardiac valve modified by laminating the hydrophilic compound network has excellent blood coagulation resistance, adhesion resistance and calcification resistance, thrombi and calcification spots can be remarkably reduced, after-implantation restenosis ofthe valve can be effectively prevented or reduced, and the calcification and early deteriotation of the valve are effectively prevented.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a heart valve modified by a hydrophilic composite network laminate and a preparation method thereof. Background technique [0002] With the acceleration of population aging, heart valve diseases have become a huge global medical burden, and the prevalence of degenerative valve diseases, ischemic valve diseases and other valve diseases has continued to rise in recent years. Artificial heart valve replacement is currently an effective means of treating end-stage heart valve disease and has saved the lives of millions of patients. Compared with mechanical valves, biological valves made of decellularized biological tissue materials are gradually being used clinically due to the advantages of no or only short-term anticoagulation and better hemodynamics similar to physiological flow patterns after implantation. . Bioprostheses currently used clinically are u...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/30A61L27/32A61L27/36A61L27/50A61L27/54
CPCA61L27/306A61L27/32A61L27/34A61L27/3625A61L27/3641A61L27/3687A61L27/50A61L27/54A61L2300/416A61L2300/42A61L2400/18A61L2420/02A61L2420/04A61L2420/08A61L2430/20A61L2430/40C08L29/04C08L71/02C08L33/02C08L75/04
Inventor 王云兵兰小蓉何周坤雷洋
Owner JILIN VENUS HAOYUE MEDICAL LTD
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