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Method for preparing blood vessel stent with polyester medicament eluting coating

A vascular stent and polyester technology, applied in the field of medical devices, achieves the effect of uniform coating, good utilization efficiency, and promotion of healing

Active Publication Date: 2008-10-08
JIANGYIN BIODEGRADE MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for polyester polymers as drug carriers (for example: polylactic acid (PLA), polyglycolide (PGA), polylactic acid glycolic acid or polylactide glycolide (PLGA), polycaprolactone (PCL), etc. And the preparation method of the coated vascular stent of the polymer obtained by the above polymer through block, grafting, blending, etc.) has not been published

Method used

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  • Method for preparing blood vessel stent with polyester medicament eluting coating
  • Method for preparing blood vessel stent with polyester medicament eluting coating
  • Method for preparing blood vessel stent with polyester medicament eluting coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The polyester drug-eluting coating of the stent is carried out in the following steps:

[0035] (1) Cleaning of vascular stents

[0036] Stainless steel brackets were cleaned with acetone, absolute ethanol, and deionized water for 5 to 15 minutes by ultrasonic vibration, dried, and set aside; NiTi alloy brackets were first used with hydrofluoric acid:concentrated nitric acid:water=1:8:16~1:2: 7 or glacial acetic acid:concentrated nitric acid=3:7~5:5, corrode for 5~7min, then use absolute ethanol and deionized water to ultrasonically clean for 5~15 minutes, dry and set aside.

[0037] (2) Preparation of coating solution

[0038]According to the ratio of drug: polymer drug-loaded material = 5% to 40%, the two are dissolved in a certain volume of organic solvent, and the concentration is 0.1% to 10% (w / v%, that is, the total amount of polymer and drug) The ratio of weight to solvent volume) uniform coating solution, for subsequent use. Its polymer drug carrier includes ...

Embodiment 2

[0044] (5) Cleaning of vascular stents

[0045] Stainless steel brackets were cleaned with acetone, absolute ethanol, and deionized water by ultrasonic vibration for 15 minutes, dried, and set aside; NiTi alloy brackets were firstly treated with hydrofluoric acid:concentrated nitric acid:water=1:8:16 or glacial acetic acid:concentrated nitric acid= 3:7, corrode for 7 minutes, then wash with absolute ethanol and deionized water with ultrasonic vibration for 15 minutes, dry and set aside.

[0046] (6) Preparation of coating solution

[0047] According to the ratio of paclitaxel: polylactic acid glycolic acid or polylactide glycolide (PLGA) = 35%, the two are dissolved in a certain volume of organic solvent, and the concentration is 1% (w / v%), that is, the polymer and the ratio of the total weight of the drug to the volume of the solvent) for a uniform coating solution, for subsequent use.

[0048] (7) Spraying of drug-eluting coating

[0049] The drug-eluting coating adopts t...

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PUM

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Abstract

The invention provides a preparation method of polyester drug-eluting coating intravascular stent. The method comprises the steps of the cleaning of the intravascular stent, the preparation of a coating solution, the coating of drug-eluting coating, the drying and disinfecting processes of drug-eluting coating, etc. The preparation method selects the polyester, which can be degraded into carbon dioxide and water in the human body in 3 to 6 months, metabolized by the human body and finally excreted out, as a polymer drug carrier. By adopting the polymer drug carrier, the stent with the coating can not only reduce the occurrence of restenosis, but also effectively reduce the occurrence of subacute thrombosis and hemangioma afterstent implantation, and guarantee the long-term clinic safety and efficiency after stent implantation. The polymer carrier with antiproliferative drugs is coated on the outer surface of the stent to achieve the function of reducing the intimal hyperplasia at one side of blood vessels and tissues. Meanwhile, fewer drugs are carried at the side facing to the blood vessel cavity to facilitate the curing of endothelium.

Description

(1) Technical field [0001] The invention relates to a material surface treatment method, in particular to a method for preparing a coating of a vascular stent, which belongs to the technical field of medical devices. (2) Background technology [0002] In 1977, Gruntzig performed the world's first percutaneous transluminal coronary angioplasty (PTCA), creating a new era of interventional cardiology. In the following 20 years, PTCA-based percutaneous coronary intervention (PCI) technology has developed rapidly and has become an important means of coronary artery revascularization, and its efficacy has been confirmed by large-scale clinical trials of evidence-based medicine. The main problem faced in the development of PCI is restenosis. The incidence of restenosis after PTCA is as high as 30% to 50%. Studies have shown that the mechanisms of restenosis are: ①elastic recoil of blood vessels; ②negative remodeling of blood vessels; ③thrombus formation and organization; Extracel...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/10A61L31/16B05D7/24B05B17/06B05D3/00A61F2/82
Inventor 李莉孙宏涛郑玉峰
Owner JIANGYIN BIODEGRADE MEDICAL TECH CO LTD
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