Method for preparing blood vessel stent with polyester medicament eluting coating
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A vascular stent and polyester technology, applied in the field of medical devices, achieves the effect of uniform coating, good utilization efficiency, and promotion of healing
Active Publication Date: 2008-10-08
JIANGYIN BIODEGRADE MEDICAL TECH CO LTD
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However, for polyester polymers as drug carriers (for example: polylactic acid (PLA), polyglycolide (PGA), polylactic acid glycolic acid or polylactide glycolide (PLGA), polycaprolac
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[0033] Example 1
[0034] The polyester drug-eluting coating for vascular stents is carried out according to the following steps:
[0035] (1) Cleaning of vascular stent
[0036] The stainless steel stents are cleaned with acetone, absolute ethanol, and deionized water by ultrasonic vibration for 5-15 minutes, dried and reserved; the NiTi alloy stents first use hydrofluoric acid: concentrated nitric acid: water = 1:8:16~1:2: 7 or glacial acetic acid: concentrated nitric acid=3:7~5:5, etch for 5~7min, then wash with absolute ethanol and deionized water ultrasonic vibration for 5~15 minutes, blow dry and set aside.
[0037] (2) Preparation of coating solution
[0038]According to the ratio of drug: polymer drug-carrying material = 5% to 40%, dissolve the two in a certain volume of organic solvent, and prepare a concentration of 0.1-10% (w / v%, that is, the total polymer and drug The ratio of the weight to the volume of the solvent) is a uniform coating solution for use. The polymer d...
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[0043] Example 2
[0044] (5) Cleaning of vascular stent
[0045] The stainless steel brackets were cleaned by ultrasonic vibration with acetone, absolute ethanol, and deionized water for 15 minutes, dried, and set aside; NiTi alloy brackets were first used with hydrofluoric acid: concentrated nitric acid: water = 1:8:16 or glacial acetic acid: concentrated nitric acid = 3:7, eroded for 7 minutes, then washed with absolute ethanol and deionized water ultrasonically for 15 minutes, dried and set aside.
[0046] (6) Preparation of coating solution
[0047] According to the ratio of paclitaxel: polylactide glycolide or polylactide glycolide (PLGA) = 35%, dissolve the two in a certain volume of organic solvent to form a concentration of 1% (w / v%, that is, polymer And the ratio of the total weight of the drug to the volume of the solvent) uniform coating solution for use.
[0048] (7) Spraying of drug-eluting coating
[0049] The drug-eluting coating adopts the method of ultrasonic ato...
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Abstract
The invention provides a preparation method of polyester drug-eluting coating intravascular stent. The method comprises the steps of the cleaning of the intravascular stent, the preparation of a coating solution, the coating of drug-eluting coating, the drying and disinfecting processes of drug-eluting coating, etc. The preparation method selects the polyester, which can be degraded into carbon dioxide and water in the human body in 3 to 6 months, metabolized by the human body and finally excreted out, as a polymer drug carrier. By adopting the polymer drug carrier, the stent with the coating can not only reduce the occurrence of restenosis, but also effectively reduce the occurrence of subacute thrombosis and hemangioma afterstent implantation, and guarantee the long-term clinic safety and efficiency after stent implantation. The polymer carrier with antiproliferative drugs is coated on the outer surface of the stent to achieve the function of reducing the intimal hyperplasia at one side of blood vessels and tissues. Meanwhile, fewer drugs are carried at the side facing to the blood vessel cavity to facilitate the curing of endothelium.
Description
(1) Technical field [0001] The invention relates to a material surface treatment method, in particular to a method for preparing a coating of a vascular stent, which belongs to the technical field of medical devices. (2) Background technology [0002] In 1977, Gruntzig performed the world's first percutaneous transluminal coronary angioplasty (PTCA), creating a new era of interventional cardiology. In the following 20 years, PTCA-based percutaneous coronary intervention (PCI) technology has developed rapidly and has become an important means of coronary artery revascularization, and its efficacy has been confirmed by large-scale clinical trials of evidence-based medicine. The main problem faced in the development of PCI is restenosis. The incidence of restenosis after PTCA is as high as 30% to 50%. Studies have shown that the mechanisms of restenosis are: ①elastic recoil of blood vessels; ②negative remodeling of blood vessels; ③thrombus formation and organization; Extracel...
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