3D printed Ti-PDA-PLGA microsphere bone defect repair stent and preparation method thereof

A 3D printing and PLGA technology, applied in pharmaceutical formulations, microcapsules, coatings, etc., can solve the problems of unguaranteed biological safety, high price, allergic reactions, etc., and achieve good bone ingrowth characteristics and biological safety , Improve hydrophilicity and biocompatibility, and enhance the effect of carrying efficiency
CN112295014AInactive Publication Date: 2021-02-02NANJING DONGSHANG BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING DONGSHANG BIOTECHNOLOGY CO LTD
Publication Date
2021-02-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a 3D printed Ti-PDA-PLGA microsphere bone defect repair stent and a preparation method thereof. A 3D printed Ti stent is prepared through a laser sintering technology; then, under a certain condition, dopamine is self-polymerized on the fiber surface of the 3D printed Ti stent to form a PDA coating, so that the 3D printed Ti-PDA stent is prepared; and then VEGF-carrying PLGA microspheres is prepared by a multiple emulsion solvent evaporation method, and finally the BMP2 and the VEGF-carrying PLGA microspheres are absorbed and fixed on the surface of the stent by an adsorption method, finally the 3D printed Ti-PDA-PLGA microsphere bone defect repair stent is prepared. The bone defect repair tissue engineering stent of the invention has the advantages of reliable mechanical property, high biological activity and safety, convenience in implantation, small trauma and low cost, which can be used for repairing treatment of bone trauma, bone tumor and bone defect afterbone infection.
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Description

[0001] Case Description

[0002] This application is a divisional application with an application date of June 15, 2018, an application number of 2018106168127, and an invention title of "a 3D printed Ti-PDA-PLGA microsphere bone defect repair scaffold". technical field

[0003] The invention belongs to the field of bone tissue repair and reconstruction, and relates to a 3D printed Ti-PDA-PLGA microsphere bone defect repair bracket and a preparation method thereof. Background technique

[0004] The repair and reconstruction of bone defects is one of the clinical problems in orthopedics. It is well known that autogenous bone is considered the gold standard for bone grafting, but its source is limited and may lead to complications such as necrosis of the supply site, postoperative chronic pain, allergic reaction, and infection. While allograft bone and xenograft bone are widely used because they come from a wide range of sources and do not require additional surgical operatio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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