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3D printed Ti-PDA-PLGA microsphere bone defect repair stent and preparation method thereof

A 3D printing and PLGA technology, applied in pharmaceutical formulations, microcapsules, coatings, etc., can solve the problems of unguaranteed biological safety, high price, allergic reactions, etc., and achieve good bone ingrowth characteristics and biological safety , Improve hydrophilicity and biocompatibility, and enhance the effect of carrying efficiency

Inactive Publication Date: 2021-02-02
NANJING DONGSHANG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, biologically active factors have the possibility of immune rejection, pathogen transmission, allergic reaction, potential tumorigenicity, and teratogenicity, and biological safety cannot be guaranteed, and clinical-grade biological factors such as rhBMP-2 and TGF-β often need to be imported, and The price is expensive, and the purchase price per milligram reaches nearly a thousand dollars

Method used

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  • 3D printed Ti-PDA-PLGA microsphere bone defect repair stent and preparation method thereof
  • 3D printed Ti-PDA-PLGA microsphere bone defect repair stent and preparation method thereof
  • 3D printed Ti-PDA-PLGA microsphere bone defect repair stent and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0048] 1. Preparation of 3D printed Ti scaffolds

[0049] Using Ti6Al4V powder as raw material, a 3D printed Ti scaffold with a 64% porosity fiber grid structure formed by laser sintering technology ( figure 2 , 3 ). Its shape can be 3D printed and personalized according to the shape of the bone defect in the area to be repaired, or it can be manufactured as a scaffold material with a fixed shape through SLM technology, and it can be filled according to the actual bone defect requirements during the operation.

[0050] 2. Preparation of 3D printed Ti-PDA scaffold

[0051] After the stent structure is constructed by 3D printing, the surface is modified using PDA. The specific steps include:

[0052] 1) preparation concentration is the hydrochloric acid (HCL) solution of 0.5mol / L;

[0053] 2) Weigh 0.61g Tris and add it into 500ml water to dissolve, after stirring, add the prepared 0.5mol / L HCL solution drop by drop to adjust to pH=8.5, and prepare Tris-HCL solution for lat...

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Abstract

The invention discloses a 3D printed Ti-PDA-PLGA microsphere bone defect repair stent and a preparation method thereof. A 3D printed Ti stent is prepared through a laser sintering technology; then, under a certain condition, dopamine is self-polymerized on the fiber surface of the 3D printed Ti stent to form a PDA coating, so that the 3D printed Ti-PDA stent is prepared; and then VEGF-carrying PLGA microspheres is prepared by a multiple emulsion solvent evaporation method, and finally the BMP2 and the VEGF-carrying PLGA microspheres are absorbed and fixed on the surface of the stent by an adsorption method, finally the 3D printed Ti-PDA-PLGA microsphere bone defect repair stent is prepared. The bone defect repair tissue engineering stent of the invention has the advantages of reliable mechanical property, high biological activity and safety, convenience in implantation, small trauma and low cost, which can be used for repairing treatment of bone trauma, bone tumor and bone defect afterbone infection.

Description

[0001] Case Description [0002] This application is a divisional application with an application date of June 15, 2018, an application number of 2018106168127, and an invention title of "a 3D printed Ti-PDA-PLGA microsphere bone defect repair scaffold". technical field [0003] The invention belongs to the field of bone tissue repair and reconstruction, and relates to a 3D printed Ti-PDA-PLGA microsphere bone defect repair bracket and a preparation method thereof. Background technique [0004] The repair and reconstruction of bone defects is one of the clinical problems in orthopedics. It is well known that autogenous bone is considered the gold standard for bone grafting, but its source is limited and may lead to complications such as necrosis of the supply site, postoperative chronic pain, allergic reaction, and infection. While allograft bone and xenograft bone are widely used because they come from a wide range of sources and do not require additional surgical operatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/34A61L27/50A61L27/54A61L27/56B22F3/11B22F3/26B22F5/00B33Y10/00B33Y80/00
CPCA61L27/06A61L27/34A61L27/50A61L27/54A61L27/56A61L2300/252A61L2300/412A61L2300/414A61L2300/45A61L2300/602A61L2300/622A61L2430/02B22F3/11B22F3/26B22F5/00B33Y10/00B33Y80/00C08L79/02
Inventor 姚庆强王黎明徐燕胡军
Owner NANJING DONGSHANG BIOTECHNOLOGY CO LTD
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