3D printed Ti-PDA-PLGA microsphere bone defect repair stent

A 3D printing and PLGA technology, applied in microcapsules, coatings, medical science, etc., can solve the problems of unguaranteed biological safety, high price, pathogen transmission, etc., and achieve good bone ingrowth characteristics and biological safety , Improved hydrophilicity and biocompatibility, and the effect of good biocompatibility
CN108853577AInactive Publication Date: 2018-11-23南京冬尚生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
南京冬尚生物科技有限公司
Publication Date
2018-11-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a 3D printed Ti-PDA-PLGA microsphere bone defect repair stent. A 3D printed Ti stent is prepared by a laser sintering technology. Then, under certain conditions, dopamine is self-polymerized on the fiber surface of the 3D printed Ti stent to form a PDA coating, thereby preparing a 3D printed Ti-PDA stent; then PLGA microspheres carrying VEGF are prepared by a double emulsion-solvent evaporation method, and finally, BMP-2 and PLGA microspheres carrying VEGF are adsorbed and immobilized on the surface of the stent by an adsorption method, and finally the 3D printed Ti-PDA-PLGA microsphere bone defect repair stent is formed. The bone defect repair tissue engineering stent disclosed by the invention has the advantages of reliable mechanical property, high biological activity and safety, convenient implantation, small trauma and low cost, and can be used for the repair treatment of bone defect after bone traumas, bone tumors and bone infection.
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Description

technical field

[0001] The invention belongs to the field of bone tissue repair and reconstruction, and relates to a 3D printed Ti-PDA-PLGA microsphere bone defect repair bracket. Background technique

[0002] The repair and reconstruction of bone defects is one of the clinical problems in orthopedics. It is well known that autogenous bone is considered the gold standard for bone grafting, but its source is limited and may lead to complications such as necrosis of the supply site, postoperative chronic pain, allergic reaction, and infection. While allograft bone and xenograft bone are widely used because they come from a wide range of sources and do not require additional surgical operations, but there are also complications such as slow integration and remodeling, immune rejection, and disease transmission, especially reducing the osteoinductive and osteoconductive.

[0003] At present, scaffold materials include bioactive calcium phosphate ceramics, calcium phosphate cem...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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