78results about How to "Easily tolerated" patented technology

Ablative treatment of metastatic bone tumors and relief of pain associated with metastatic bone tumors is achieved by heat ablation of the bone tumor or tissue near the bone tumor by an ablation probe. In one form the probe is an electrode coupled to a high frequency power supply to provide ablative heating of tissue proximate to an electrode that is placed in or near the bone tumor. Cooling of the electrode by fluid circulation from a cooling apparatus outside the patient's body may be used to enlarge the region of high frequency heating around the electrode. Image guidance of the electrode placement may be monitored by an imaging device. Tracking of the electrode by an image-guided navigator helps in placement of the electrode with respect to the configuration of the bone and bone metastasis. A set of tools accommodates biopsy and various shapes of electrodes according to clinical requirements. Several forms of electrodes, energy delivery and cooling apparatus and methods accommodate the specific objectives.

Ablative treatment of metastatic bone tumors and relief of pain associated with metastatic bone tumors is achieved by heat ablation of the bone tumor or tissue near the bone tumor by an ablation probe. In one form the probe is an electrode coupled to a high frequency power supply to provide ablative heating of tissue proximate to an electrode that is placed in or near the bone tumor. Cooling of the electrode by fluid circulation from a cooling apparatus outside the patient's body may be used to enlarge the region of high frequency heating around the electrode. Image guidance of the electrode placement may be monitored by an imaging device. Tracking of the electrode by an image-guided navigator helps in placement of the electrode with respect to the configuration of the bone and bone metastasis. A set of tools accommodates biopsy and various shapes of electrodes according to clinical requirements. Several forms of electrodes, energy delivery and cooling apparatus and methods accommodate the specific objectives.

An improved continuous process for converting methane, natural gas, or other hydrocarbon feedstocks into one or more higher hydrocarbons or olefins by continuously cycling through the steps of alkane halogenation, product formation (carbon-carbon coupling), product separation, and regeneration of halogen is provided. Preferably, the halogen is continually recovered by reacting hydrobromic acid with air or oxygen. The invention provides an efficient route to aromatic compounds, aliphatic compounds, mixtures of aliphatic and aromatic compounds, olefins, gasoline grade materials, and other useful products.

The invention is a locally mounted light source for light activation of tooth whitening compositions. A support in the form of a bridge attached to a retractor or as part of a mouth guard has integral therewith, a small and lightweight light source, such as could be provided by one or more high-intensity LED's, though other light sources could be used. The light source may be in the form of an array, powered by either a direct electrical connection to a power supply or by battery power, for example, with a battery pack worn by the user. The light source is thus located in proximity to the tooth surfaces regardless of head movement or orientation, increasing user mobility and comfort.

The present invention relates to the field of methods and apparatus for the determination of various conditions of gastric and gastro-intestinal malfunction, especially those performed by means of breath tests.

At least one exemplary embodiment is directed to a method of auditory communication comprising: measuring a data set; identifying the type of data set; obtaining the auditory cue associated with the type of data set; and generating an auditory notification; and emitting the auditory notification.

A multiple generator having a vertical post and multiple vertical tubes has the generators positioned vertically one above the other. Each is cylindrical in shape and has two rings separated by connecting fins. The cylinders vary in size with the top being the smallest, the middle or second being larger and the third being the largest. With low winds, only the smallest generator turns. As wind velocity increases, the small generator rotates faster until clutches in a clutch ring move outwardly until they engage and secure to the second generator so both generators move together. As wind speed increases, clutches on the second generator move outwardly until they engage and secure to the third generator and all generators now rotate together. Thus varying amounts of electricity are generated depending on the wind speed and which generators are active. Each generator has its own rotating shaft with ball bearings between the post and first tube and between the first and second tubes. A cage protects the device from birds or other air-suspended articles.

A dental oral appliance for use with patients who suffer with sleep disorders, to reduce or eliminate snoring and to open the airway for a sleeping individual who suffers with obstructive sleep apnea. The appliance covers the inside (lingual) of the upper teeth and has an open palate. Retention for the appliance is provided by either clasps placed over the upper right and left molars and a retainer in the anterior area or by an occlusal coverge of the upper teeth. A raised incisor ramp that extends from the incisal tip (biting edge) of the incisors toward the lingual, or posterior raised ramps, separate the posterior teeth to reduce spasm on the temporalis muscle. A transverse, transpalatal ramp, which extends from the inside (lingual) of the upper right molars to the inside of the upper left molars, covers the tongue and holds it down, opening the airway.

A sample collection substrate of aerogel and / or xerogel materials bound to a support structure is used as a solid phase microextraction (SPME) device. The xerogels and aerogels may be organic or inorganic and doped with metals or other compounds to target specific chemical analytes. The support structure is typically formed of a glass fiber or a metal wire (stainless steel or kovar). The devices are made by applying gel solution to the support structures and drying the solution to form aerogel or xerogel. Aerogel particles may be attached to the wet layer before drying to increase sample collection surface area. These devices are robust, stable in fields of high radiation, and highly effective at collecting gas and liquid samples while maintaining superior mechanical and thermal stability during routine use. Aerogel SPME devices are advantageous for use in GC / MS analyses due to their lack of interfering background and tolerance of GC thermal cycling.

A high strength hydrogel having a constant swelling pressure upon implantation and thereafter is formed by preparing a hydrogel solution and then injecting the solution into a mold and cause to gel. The molded gel is then washed in a saline solution from about one day to twelve weeks, after which the gel is irradiated for sterilization purposes, dehydrated and packaged. The pre-treatment with the use of a physiologic solution results in an implant which exhibits a constant swelling pressure profile after implantation.

The invention provides methods and compositions for treating erectile dysfunction. The methods include the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a vasoactive prostaglandin composition of a semi-solid consistency. The composition comprises a vasoactive prostaglandin, a penetration enhancer, a shear-thinning polysaccharide, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N-substituted amino)-alkanoate ester, a (N-substituted amino)-alkanol alkanoate, or a mixture of these enhancers. The lipophilic compound may be an aliphatic C1 to C8 alcohol, aliphatic C2 to C30 ester, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system providing a buffered pH value for said composition in the range of about 3 to about 7.4.

The present invention provides methods for treating an individual having solid or lymphatic tumor comprising local administration to the site of the tumor an infectious agent an immunomodulator (including a combination of immunomodulators). The methods may further comprise local administration to the site of the tumor inactivated tumor cells. Also provided are compositions and kits for the cancer therapy methods.

Apparatus and method for providing breathing gases to a subject employs an exchanger taking up a quantity of a given component, such as CO2, from expiratory breathing gases passing through the exchanger and thereafter releasing the given component in inspiratory breathing gases subsequently passing through the exchanger. The exchanger may be selectively inserted in a flow path for the breathing gases for this purpose. Or, the breathing gases may be selectively passed through and bypassed around the exchanger. The apparatus and method may be used for non-invasive determination of the functional cardiac output of a patient using the differential form of the Fick equation.

A method and device for stopping a person from snoring while sleeping comprising a narrow strip having adhesive covering one surface or a buccal tab which can be affixed to a snore prevention intra-oral device, both of which block the snoreway space of the person.

Variable width electrically conductive (i) traces and (ii) pads in the forms of castellations and connecting traces upon the surfaces of volume microminiature electronic components permit variable area electrical interconnection in three dimensions, particularly of monolithic, buried-substrate, multiple ceramic capacitors to integrated circuit receivers and amplifiers to make microminiature hearing aids insertable within the ear canal. A preferred embodiment monolithic multiple capacitor with side, top and bottom surfaces has a number of electrically conductive parallel layers disposed within its body with a conductive trace extending from each layer to be exposed upon a side surface. Metallized bus strips of at least two widths extend along the side surface; relatively thinner bus strips selectively interconnecting the exposed traces to form a plurality of capacitors while the relatively thicker bus strips selectively extend at least some traces to one or more edge(s) of the top and / or bottom surfaces of the body where they may be externally connected, normally to piggy-backed components, by reflow soldering. The different-width metallized bus strips are preferably made by rectangular saw-cut slots in the body at differently spaced intervals, the rectangular saw-cuts forming castellations having a greater depth than width to reduce parasitic capacitance.

A sample collection substrate of aerogel and / or xerogel materials bound to a support structure is used as a solid phase microextraction (SPME) device. The xerogels and aerogels may be organic or inorganic and doped with metals or other compounds to target specific chemical analytes. The support structure is typically formed of a glass fiber or a metal wire (stainless steel or kovar). The devices are made by applying gel solution to the support structures and drying the solution to form aerogel or xerogel. Aerogel particles may be attached to the wet layer before drying to increase sample collection surface area. These devices are robust, stable in fields of high radiation, and highly effective at collecting gas and liquid samples while maintaining superior mechanical and thermal stability during routine use. Aerogel SPME devices are advantageous for use in GC / MS analyses due to their lack of interfering background and tolerance of GC thermal cycling.

Preparations with deodorizing action are provided. The preparations include the zinc salt of ricinoleic acid; amino-functional amino acids; solubility promoters; organic and / or inorganic acids; and, optionally, water.

A dental oral appliance for use with patients who suffer with sleep disorders, to reduce or eliminate snoring and to open the airway for a sleeping individual who suffers with obstructive sleep apnea. The appliance covers the inside (lingual) of the upper teeth and has an open palate. Retention for the appliance is provided by either clasps placed over the upper right and left molars and a retainer in the anterior area or by an occlusal coverage of the upper teeth. A raised incisor ramp that extends from the incisal tip (biting edge) of the incisors toward the lingual, or posterior raised ramps, separate the posterior teeth to reduce spasm on the temporalis muscle. A transverse, transpalatal member, which extends from the inside (lingual) of the upper right molars to the inside of the upper left molars, covers the tongue, preventing it from moving upward or backward during sleep, opening the airway.

A control device and a method for controlling several master axes in a machine, for example a production machine, is disclosed. The disclosed method includes the steps of defining profiles of desired values for a plurality of master axes, determining for each master axis a current desired value and also a current desired value for a slave axis using a logic combination rule, controlling a first drive in accordance with the current desired value of the slave axis, and if the dynamics controlling the first drive exceeds an upper dynamics limit, starting at the next clock pulse to modify determination of the current desired values for at least one of the master axes, and controlling the first drive with a reduced dynamics until the reduced dynamics falls below a lower dynamics limit.

A multiple generator having a vertical post and multiple vertical tubes has the generators positioned vertically one above the other. Each is cylindrical in shape and has two rings separated by connecting fins. The cylinders vary in size with the top being the smallest, the middle or second being larger and the third being the largest. With low winds, only the smallest generator turns. As wind velocity increases, the small generator rotates faster until clutches in a clutch ring move outwardly until they engage and secure to the second generator so both generators move together. As wind speed increases, clutches on the second generator move outwardly until they engage and secure to the third generator and all generators now rotate together. Thus varying amounts of electricity are generated depending on the wind speed and which generators are active. Each generator has its own rotating shaft with ball bearings between the post and first tube and between the first and second tubes. A cage protects the device from birds or other air-suspended articles.

A spinal implant for replacing the natural nucleus of the disc made from a polymer such as hydrogel having a radiopaque material located within the polymer. The material may be in the form of a powder dispersed throughout the polymer or may be in he form of a powder dispersed in layers or in other specific locations within the polymer. The radiopaque material is metal such as gold, tungsten, titanium, tantalum or platinum. The metal may also be in the form of a foil or wire located within the hydrogel such as polyurethane, thereby making the implant visible on x-rays. Other polymers besides hydrogel may be used with the radiopaque material being dispersed therein.

At least one exemplary embodiment is directed to a method of auditory communication comprising: measuring a data set; identifying the type of data set; obtaining the auditory cue associated with the type of data set; and generating an auditory notification; and emitting the auditory notification.

A component includes a first member, a second member and a device for fastening the first member to the second member. A first hole extends through a portion of the first member and a second hole extends through a portion of the second member. The first member and the second member are positioned such that the first hole and the second hole coincide. The fastening device includes an elongated fastening element arranged in the coinciding holes and a bushing arrangement arranged around the fastening element and adapted to establish a load transmission path between the first member and the second member. A first part of the bushing arrangement is arranged such that an inner surface thereof is positioned at a distance from an exterior surface of the fastening element for establishing a first load transmission path via the bushing arrangement and bypassing the fastening element in a first load condition. Further, the fastening device is adapted to allow the first member to move relative to the fastening element in a second load condition such that the first part of the bushing arrangement can be brought into contact with the fastening element for establishing a second load transmission path between the first member and the second member via the fastening element.

The present invention relates to the field of methods and apparatus for the determination of various conditions of gastric and gastro-intestinal malfunction, especially those performed by means of breath tests.

Methods of determining gastro-intestinal conditions by performing a succession of breath tests or others tests, particularly for determining the gastric emptying or gastric accomodation condition of a subject. Methods of performing successive gastric emptying tests with different test meals are also presented, enabling the gastric accommodation to be determined. The effects of different test means on the results is presented. Novel substrates for use in such tests are suggested, including the use of micro-encapsulation. Breath tests for the detection of bacterial overgrowth, lactose intolerance and combinations thereof are presented.