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Composite mesoporous bioglass/graphene oxide bone cement and preparation method thereof

A graphene composite, bioglass technology, applied in the field of biomedical materials, can solve the problems of poor treatment effect, metastasis, toxic and side effects, etc.

Active Publication Date: 2018-10-30
HUANGGANG NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Bone tumor is a common clinical disease at present. Resection is usually used to treat bone tumors. However, there are two basic problems after surgery: first, the filling and reconstruction of the residual tumor cavity after surgery; Recurrence and metastasis of tissue residual tumor
[0004] Drug chemotherapy is one of the main means of treating tumors at present, but drug chemotherapy will cause serious side effects, and problems such as poor therapeutic effect due to drug resistance of tumor cells

Method used

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  • Composite mesoporous bioglass/graphene oxide bone cement and preparation method thereof
  • Composite mesoporous bioglass/graphene oxide bone cement and preparation method thereof
  • Composite mesoporous bioglass/graphene oxide bone cement and preparation method thereof

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Embodiment 1

[0028] 5.0g graphite and 2.5g NaNO 3 Added to 115mL concentrated H 2 SO 4 and stirred and dispersed in an ice-water bath for 25min; then 15.0g KMnO 4 Add to the above mixture and stir at less than 10°C for 25min; then heat to 35°C and stir for 45min, then add 140mL deionized water and stir at 98°C for 45min; then dilute the mixture with deionized water to 700mL, dilute and then add 30mL H 2 o 2 (30%) to reduce unreacted potassium permanganate, filter and wash with 50mL concentrated hydrochloric acid to obtain sediment; then, the sediment is diluted with deionized water and centrifuged at 11000rpm; the supernatant is poured out and Add deionized water to wash, and repeat the above centrifugal cleaning steps several times until the pH of the supernatant is 7; finally, the viscous obtained is ultrasonically dispersed, and then centrifuged at a speed of 3000rpm, and the upper liquid is collected and freeze-dried to obtain Graphene oxide.

[0029]Add 4g of P123 into 60g of et...

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Abstract

The invention provides composite mesoporous bioglass / graphene oxide bone cement and a preparation method thereof. The composite mesoporous bioglass / graphene oxide bone cement is used for bone defect repair and residual tumor therapy after bone tumor operations and is provided with a photothermal effect. The preparation method of the composite mesoporous bioglass / graphene oxide bone cement includes: (1) preparing graphene oxide; (2) preparing mesoporous bioglass powder; (3) preparing bone cement curing liquid; (4) preparing the composite mesoporous bioglass / graphene oxide bone cement with the photothermal effect. The prepared bone cement has higher mechanical strength as compared with a pure mesoporous bioglass bone cement, is high in biocompatibility and biological activity and capable offacilitating proliferation, differentiation and osteogenesis of bone marrow mesenchymal stem cells, and is expected to provide a new strategy for bone defect reparative therapy after the bone tumor operations clinically.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a composite bone cement with photothermal effect, more particularly to a mesoporous bioglass / graphene oxide composite bone cement with photothermal effect and a preparation method thereof. technical background [0002] Bone tumor is a common clinical disease at present. Resection is usually used to treat bone tumors. However, there are two basic problems after surgery: first, the filling and reconstruction of the residual tumor cavity after surgery; Recurrence and metastasis of tissue residual tumor. Therefore, there is an urgent clinical need for bone repair materials that can repair bone defects for tissue reconstruction and inhibit residual tumor cells. [0003] For the filling and reconstruction of the irregular tumor cavity left after bone tumor resection, the implanted material must have certain shape plasticity. Compared with traditional bone repair materials, in additi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/08A61L27/54A61K41/00A61P35/00
CPCA61K41/0052A61L27/08A61L27/10A61L27/54A61L2300/412A61L2430/02A61P35/00
Inventor 朱钰方田正芳陈砚美阮志军
Owner HUANGGANG NORMAL UNIV
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