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A kind of mesoporous bioglass/graphene oxide composite bone cement and preparation method thereof

A graphene composite and bioglass technology, applied in the field of biomedical materials, can solve problems such as poor treatment effect, transfer, and side effects

Active Publication Date: 2021-05-04
HUANGGANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Bone tumor is a common clinical disease at present. Resection is usually used to treat bone tumors. However, there are two basic problems after surgery: first, the filling and reconstruction of the residual tumor cavity after surgery; Recurrence and metastasis of tissue residual tumor
[0005] Drug chemotherapy is currently one of the main means of treating tumors, but drug chemotherapy can cause serious side effects, and problems such as poor therapeutic effect due to drug resistance of tumor cells

Method used

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  • A kind of mesoporous bioglass/graphene oxide composite bone cement and preparation method thereof
  • A kind of mesoporous bioglass/graphene oxide composite bone cement and preparation method thereof
  • A kind of mesoporous bioglass/graphene oxide composite bone cement and preparation method thereof

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Embodiment 1

[0029] 5.0g graphite and 2.5g NaNO 3 Added to 115mL concentrated H 2 SO 4 and stirred and dispersed in an ice-water bath for 25min; then 15.0g KMnO 4 Add to the above mixture and stir at less than 10°C for 25min; then heat to 35°C and stir for 45min, then add 140mL deionized water and stir at 98°C for 45min; then dilute the mixture with deionized water to 700mL, dilute and then add 30mL H 2 o 2 (30%) to reduce unreacted potassium permanganate, filter and wash with 50mL concentrated hydrochloric acid to obtain sediment; then, the sediment is diluted with deionized water and centrifuged at 11000rpm; the supernatant is poured out and Add deionized water to wash, and repeat the above centrifugal cleaning steps several times until the pH of the supernatant is 7; finally, the viscous obtained is ultrasonically dispersed, and then centrifuged at a speed of 3000rpm, and the upper liquid is collected and freeze-dried to obtain Graphene oxide.

[0030]Add 4g of P123 into 60g of et...

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Abstract

The invention provides a mesoporous bioglass / graphene oxide composite bone cement with photothermal effect, which is used for bone defect repair after bone tumor surgery and residual tumor treatment, and a preparation method thereof. The preparation method includes: (1) preparation of graphene oxide; (2) preparation of mesoporous bioglass powder; (3) preparation of bone cement solidification liquid; (4) mesoporous bioglass / oxidation with photothermal effect Preparation of graphene composite bone cement. Compared with pure mesoporous bioglass bone cement, the mechanical strength of the composite bone cement prepared by the present invention is significantly enhanced; and it has good biocompatibility and high biological activity, and can promote the proliferation, differentiation and osteogenesis of human bone marrow mesenchymal stem cells, and is expected to be Clinically, it provides a new strategy for the repair of bone defects after bone tumor surgery.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a composite bone cement with photothermal effect, more particularly to a mesoporous bioglass / graphene oxide composite bone cement with photothermal effect and a preparation method thereof. [0002] technical background [0003] Bone tumor is a common clinical disease at present. Resection is usually used to treat bone tumors. However, there are two basic problems after surgery: first, the filling and reconstruction of the residual tumor cavity after surgery; Recurrence and metastasis of tissue residual tumor. Therefore, there is an urgent clinical need for bone repair materials that can repair bone defects for tissue reconstruction and inhibit residual tumor cells. [0004] For the filling and reconstruction of the irregular tumor cavity left after bone tumor resection, the implanted material must have certain shape plasticity. Compared with traditional bone repair materials, i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/10A61L27/08A61L27/54A61K41/00A61P35/00
CPCA61K41/0052A61L27/08A61L27/10A61L27/54A61L2300/412A61L2430/02A61P35/00
Inventor 朱钰方田正芳陈砚美阮志军
Owner HUANGGANG NORMAL UNIV
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