The invention provides ketogenic nutrient meal replacement powder. The ketogenic nutrient meal replacement powder is prepared from the following components: medium chain triglyceride microcapsule powder, gamma-linolenic acid oil microcapsule powder, high oleic sunflower oil microcapsule powder, rice bran fatty alkanol microcapsule powder, oat fiber, soy protein isolate, rice protein, yeast protein, psyllium seed husk powder, a potato extract, an agaricus bisporus extract, a white kidney bean extract, erythritol, grape fruit powder, compound vitamins, compound minerals and xanthan gum. The formula contains high-content fat, contains dietary fiber, various vitamins and minerals, can increase satiety, control the decomposition and absorption of carbohydrates, avoid fat accumulation, and can effectively improve the unwell symptoms of a user when glucose energy supply is converted into ketone body energy to achieve nutrient balance, and can be used as a ketogenic diet for weight loss peopleand epilepsy patients.