The invention discloses a sachet capable of adjusting immunity and a preparation method of the sachet. The sachet consists of wrinkled giant hyssop, folium artemisiae argyi, clove, cassia bark, galanga resurrectionlily rhizome, fineleaf schizonepeta herb, purple perilla, asarum, ligusticum wallichii, radix angelicae, ligusticum sinense oliver, rhizoma nardostachyos, peppermint, rhizoma atractylodes, acorus calamus and borneol, and the sachet is prepared by drying, mixing and grinding the medicinal materials, filtering the medicinal materials by virtue of a 80-mesh sieve, optionally dividing the medicine powder into 20-100g and respectively packaging the medicine powder in cotton bags so as to obtain a finished product. When the sachet is used, the medicine bag is placed beside a pillow in a bed or the medicine powder in small bag is worn on the chest; the fragrance of the sachet is pleasant for heart and spleen as well as for mind, and is conducive to activating the potential functions of a human body; the sachet, by long-term consumption, is of significance for activating and regulating body functions, enhancing disease resistance of the body, preventing cold, regulating and protecting gastrointestinal functions, regulating and enhancing functions of cardio-cerebral vessels, promoting sleep, recovering strength and relieving sub-health. Since ancient times, Chinese people have a tradition of hanging traditional Chinese medicines in front of doors and inside rooms to prevent and treat diseases, and especially, to wear a sachet is a custom started from the ancient times.