Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Lingzhiol A and application of lingzhiol A in drug production and foods

A technology of ganoderma phenol and health food, which is applied in the field of medicine, and can solve problems such as the activity of diabetic nephropathy or chronic kidney disease, which has no value treatment prospect

Active Publication Date: 2014-11-26
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are no related reports on the compound of the present invention and its activity with promising therapeutic prospects for diabetic nephropathy or chronic kidney disease

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Lingzhiol A and application of lingzhiol A in drug production and foods
  • Lingzhiol A and application of lingzhiol A in drug production and foods
  • Lingzhiol A and application of lingzhiol A in drug production and foods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Separation and purification of compound 1:

[0019] Chizhi (Ganoderma lucidum) 80kg, pulverized, extracted with 95% ethanol under reflux (2×360L×2h), combined the extracts and recovered the solvent under reduced pressure to obtain a crude extract, suspended the crude extract in an appropriate amount of water, and then used an equal volume of Extracted three times with ethyl acetate, combined the extracts, and concentrated under reduced pressure to obtain 1.1 kg of ethyl acetate extract. The phenolic substance was subjected to silica gel column chromatography (silica gel 200-300 mesh, 7kg), chloroform-methanol system gradient elution (99:1, 98:2, 97:3, 96:4, 95:5, 94:6 , 93:7, 92:8, 90:10, 85:15, 80:20, 50:50), each solvent gradient is 1.5 times the column volume, collected according to 500mL each) to obtain 7 combined fractions. Component 4 (420g) was eluted through silica gel column chromatography with chloroform / acetone / acetic acid (10:1:0.2) to obtain 4 subcomponent...

Embodiment 2

[0028] Any one of the compounds in Example 1 can be made into an injection after adding water for injection according to the conventional method, finely filtering, potting and sterilizing.

Embodiment 3

[0030] Any one of the compounds in Example 1 was dissolved in sterile water for injection, filtered through a sterile funnel, subpackaged, freeze-dried at low temperature, and aseptically melt-sealed to obtain a powder injection.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Glossy ganoderma as a traditional Chinese medicine is called immortal grass since ancient times and known as the ability to treat various diseases; a pair of lingzhiol A optical enantiomers is purified from ganoderma lucidum, and the lingzhiol A optical enantiomers have obvious effects on inhibiting rat renal mesangial cell strains induced by high glucose to generate reactive oxide species, IL-6, fibronectin and IV type collagen, and also can obviously inhibit the phosphorylation of the renal tubular epithelial cell Smad3 induced by TGF-beta1, so that the application prospect of the compound in preparation of medicines for treating diabetic nephropathy and chronic nephropathy is shown.

Description

Technical field: [0001] The invention belongs to the technical field of medicines, and in particular relates to ganoderma phenol A, a pharmaceutical composition containing it and its application in preparing medicine or health food for treating diabetic nephropathy or chronic kidney disease. Background technique: [0002] The hazards, pathological mechanisms, and methods and principles of drug research of diabetic nephropathy or chronic kidney disease are clearly described by the applicant in the published patent application (Chinese patent publication number: CN102153630A). As we all know, changes in modern diet and lifestyle, coupled with environmental pollution, drug abuse and other factors, have led to frequent and high incidences of diabetic complications and chronic kidney diseases such as renal fibrosis worldwide. However, there is still a lack of clinically effective drugs for these diseases. [0003] Modern studies have shown that the occurrence and development of d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/93A61K31/365A61P13/12A61P3/10A23L1/30A23L33/105
Inventor 程永现晏永明方萍吕青王心龙罗杰
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com