The invention relates to a therapeutic agent, composition and method for promoting restoration of hematopoiesis function, in particular to a hematopoiesis promoting therapeutic agent, composition and method for resisting toxic and side effect of radiotherapy and chemotherapy. The optical execution mode of the invention comprises a pharmaceutical composition contained IL-12 or pharmaceutical composition comprising at least two of the following protein factor: CSF-1,EGF,IGF-1,TNF-alpha,VEGF,MIP-1,IL-1,IL-6,FGF-1,FGF-2,FGF-7,PDGF,TGF-beta1,TGF-beta2,TGF-alpha,ANG-1,MCP-1,PF-4 or IL-8 The pharmaceutical composition can be administered before, in and after the basic therapy process like radiotherapy and/or chemotherapy.