Applications of a TGF-beta1 receptor blocker in preparation of medicines treating Hydatid disease

A receptor blocker, TGF-technology, applied in the field of biomedicine

Inactive Publication Date: 2015-09-16
TONGREN UNIV
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in theory, the use of TGF-β1 receptor blockers can be used to prevent the recurrence of echinococcosis, but how to use TGF-β1 receptor blockers to prepare for the treatment of echinococcosis, especially for acanthosis granulosus? Host in coccidioid infection, not yet reported

Method used

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  • Applications of a TGF-beta1 receptor blocker in preparation of medicines treating Hydatid disease
  • Applications of a TGF-beta1 receptor blocker in preparation of medicines treating Hydatid disease
  • Applications of a TGF-beta1 receptor blocker in preparation of medicines treating Hydatid disease

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Embodiment Construction

[0027] 1. Preparation of Echinococcus granulosus protoscole:

[0028] From sheep livers infected with echinococcosis granulosus, aseptically extract the contents of uncalcified, non-infected, and complete single-cystic echinococcosis granulosus cysts, put them in sterile centrifuge tubes, and protoscole (Protoscole , PSC) naturally precipitated, and then rinsed 3 times with sterile PBS (pH 7.3) containing 100IU / mL penicillin and streptomycin double antibodies, removed the fragments of brood cysts to allow natural precipitation, stained with 0.5% eosin for 5min, and in The number of active parasites (>90%) was identified under a microscope, diluted with sterile PBS containing double antibodies to prepare a protoscole suspension containing 10,000 protoscolmes / mL, and set aside.

[0029] 2 Mouse spleen cell isolation:

[0030] Mice were killed by neck dislocation, spleens were aseptically removed, and splenocytes were scraped out in a small plate containing a little PBS with one...

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Abstract

The invention provides applications of a TGF-beta1 receptor blocker in preparation of medicines treating the Hydatid disease. Concretely, through immune escape of TGF-beta1 receptor blockers for inhibition of infection of intermediate hosts by echinococcosis granulosis cysts, increase of the number of CD<4+>T cells, decrease of the number of CD<8+> T cells, raising of the CD<4+>/CD<8+>T cell ratio, decrease of the number of CD<4+>CD<25+> T cells, increase of expression of active receptors NKG2D of NK cells and raising of the cracking rate of target cells Yac-1 by NK cells in host cells are caused. Researches show that NK cell viability is in positive correlation with active receptor NKG2D number. Results show that the provided method can enhance inhibition of hosts to echinococcosis granulosis cyst infection effectively. The method can be used for treating the Hydatid disease effectively, and has good clinic application prospects.

Description

technical field [0001] The invention relates to a method for treating echinococcosis, in particular to the application of a TGF-β1 receptor blocker in the preparation of medicines for treating echinococcosis, and belongs to the field of biomedicine. Background technique [0002] Hydatid disease, also known as echinococcosis, is a parasitic disease that seriously affects the health of humans and animals caused by hydatid larvae parasitizing on intermediate hosts. During the surgical treatment of echinococcosis or in normal patients, due to the accidental rupture of the cyst, part of the protoscole may enter the tissue, resulting in reinfection, which also brings great difficulties to the treatment of echinococcosis. [0003] Aiming at the treatment of echinococcosis, various treatment schemes have been developed in this field, mainly surgical operation, supplemented by internal medicine and chemotherapy. However, this method has many disadvantages, such as surgical treatment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/517A61K31/4439A61P33/10
Inventor 印双红张俊波陈雪玲陈小林徐芳洁
Owner TONGREN UNIV
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