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Ganoderma cochlear phenols A and B, pharmaceutical compositions of ganoderma cochlear phenols A and B and applications of ganoderma cochlear phenols A and B and pharmaceutical compositions in preparation of medicines and food

A technology of ganoderma phenol and ganoderma lucidum, which is applied in the field of pharmaceutical technology and food, and can solve the problems of anti-chronic kidney disease and other problems that have not been seen

Inactive Publication Date: 2015-03-25
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inventor thinks that it may contain anti-chronic kidney disease active substances, but there is no relevant report on the compound involved in the present invention and its anti-chronic kidney disease in the prior art

Method used

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  • Ganoderma cochlear phenols A and B, pharmaceutical compositions of ganoderma cochlear phenols A and B and applications of ganoderma cochlear phenols A and B and pharmaceutical compositions in preparation of medicines and food
  • Ganoderma cochlear phenols A and B, pharmaceutical compositions of ganoderma cochlear phenols A and B and applications of ganoderma cochlear phenols A and B and pharmaceutical compositions in preparation of medicines and food
  • Ganoderma cochlear phenols A and B, pharmaceutical compositions of ganoderma cochlear phenols A and B and applications of ganoderma cochlear phenols A and B and pharmaceutical compositions in preparation of medicines and food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Separation and purification of compounds 1 and 2:

[0021]Ganoderma cochlear (Ganoderma cochlear) 100kg, pulverized, extracted with 70% ethanol at room temperature (6 × 300L × 48h), combined the extracts and recovered the solvent under reduced pressure to obtain a crude extract, suspended the crude extract in an appropriate amount of water, and then used Equal volumes of ethyl acetate were extracted three times, the extracts were combined, and concentrated under reduced pressure to obtain 2 kg of ethyl acetate extract. The substance was subjected to silica gel column chromatography (silica gel 200-300 mesh, 10kg), chloroform-methanol system gradient elution (100:0, 99:1, 98:2, 97:3, 96:4, 95:5, 94 :6, 93:7, 92:8, 90:10, 85:15, 80:20, 50:50), each solvent gradient is 1.5 times the column volume, collected according to each 500mL) to obtain 7 combined fractions . Component 4 (420g) was passed through Sephadex LH-20 (MeOH / H 2 (2,80:20) column chromatography obtains 7 su...

Embodiment 2

[0038] Any one of the compounds in Example 1 can be made into an injection after adding water for injection according to the conventional method, finely filtering, potting and sterilizing.

Embodiment 3

[0040] Any one of the compounds in Example 1 was dissolved in sterile water for injection, filtered through a sterile funnel, subpackaged, freeze-dried at low temperature, and aseptically melt-sealed to obtain a powder injection.

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Abstract

The invention relates to ganoderma cochlear phenols A and B, pharmaceutical compositions of ganoderma cochlear phenols A and B and applications of ganoderma cochlear phenols A and B and the pharmaceutical compositions thereof in preparation of medicines and food. Two racemates are separated from ganoderma cochlear and identified, and then the two racemates are split into two pairs of optical enantiomers which are named as levorotatory or dextrorotatory ganoderma cochlear phenols A and B respectively. Researches show that both the racemates and the enantiomers are capable of significantly inhibiting TGF-beta1-induced renal tubular epithelial cell from generating fibronectin, I type collagen and alpha-smooth muscle actin (alpha-SMA), and researches further find that both the racemates and the enantiomers are capable of significantly inhibiting the TGF-beta1-induced renal tubular epithelial cell Smad3 from phosphorylation, which means that the compounds have application prospects in the field of preparation of medicines for resisting renal fibrosis and chronic nephrosis.

Description

Technical field: [0001] The invention belongs to the field of pharmaceutical technology and food, and in particular relates to anteganoseol A and B and their pharmaceutical composition, and their application in the preparation of medicine or health food for treating renal fibrosis or chronic kidney disease. Background technique: [0002] The harm of chronic kidney disease, the pathological mechanism and the method and principle of drug research are all clearly described by the inventor in the published Chinese patent (publication number: CN 102153630A). Due to the influence of many factors such as drugs and diet, the incidence of chronic kidney disease has exceeded 10%. When chronic kidney disease progresses to renal failure, it can only rely on kidney transplantation and hemodialysis. However, due to the lack of therapeutic drugs, there is no good intervention method for chronic kidney disease. [0003] Studies have shown that chronic kidney disease, including fibrosis, is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/10C07D311/94A61K31/357A61K31/352A61P13/12A23L1/30A23L33/10
CPCA23G4/06A23G2200/00A23L33/10C07D311/94C07D493/10
Inventor 程永现豆曼邸磊吕青
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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