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Use of transforming growth factor (TGF)-beta1 inhibitor in lung cancer treatment

A TGF-, inhibitor technology, applied in medical preparations containing active ingredients, organic active ingredients, drug combinations, etc., can solve the problems of unclear, increase the radiation sensitivity of lung cancer cells, etc., to delay growth and reduce cell cloning. Formative capacity, effects of altering cell cycle distribution

Inactive Publication Date: 2014-04-16
SUZHOU UNIV
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Problems solved by technology

However, until now, whether inhibition of TGF-β1 can increase the radiosensitivity of lung cancer cells is unclear

Method used

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  • Use of transforming growth factor (TGF)-beta1 inhibitor in lung cancer treatment
  • Use of transforming growth factor (TGF)-beta1 inhibitor in lung cancer treatment
  • Use of transforming growth factor (TGF)-beta1 inhibitor in lung cancer treatment

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Embodiment Construction

[0024] The following will clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0025] (1) Cell culture and irradiation

[0026] Both H460 and H1299 cells were purchased from the Cell Bank of the Chinese Academy of Sciences. Cells were cultured in RPMI 1640 containing high glucose, containing 10% fetal bovine serum (Hyclone), 1 mM sodium pyruvate (Sigma-Aldrich), 100 U / ml penicillin-streptomycin (Beyond Institute of Biotechnology) ) and 1 mM HEPES (pH7.2, Nanjing Rotary). Twenty-four hours after cell inoculation, the cells were replaced with fresh medium containing SB431542, and cultured for 1...

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Abstract

The invention discloses use of a transforming growth factor (TGF)-beta1 inhibitor in lung cancer treatment. The TGF-beta1 inhibitor inhibits a TGF-beta1 channel to increase the radiosensitivity of lung cancer cells. Through the manner, according to the use of the TGF-beta1 inhibitor in lung cancer treatment, the sensitivity enhancement effect of the TGF-beta1 inhibitor on the lung cancer cells is caused by inhibition on non-homologous end joining repair of deoxyribonucleic acid (DNA) double-strand break, change of cycle distribution of the lung cancer cells after irradiation, and obvious reduction of tumor growth by the TGF-beta1 inhibitor combined with X-ray treatment of 5Gy. The DNA repair capacity can be reduced by inhibition on the TGF-beta1 channel of tumor cells before irradiation, the cell cycle distribution is changed, the cell cloning ability is reduced, the tumor growth is delayed, and effective auxiliary means are provided by inhibiting the TGF-beta1 channel as radiotherapy of a patient with a lung cancer.

Description

technical field [0001] The invention relates to the field of lung cancer treatment, in particular to the use of a TGF-β1 inhibitor in the treatment of lung cancer. Background technique [0002] With the increasing incidence of lung cancer in our country year by year, lung cancer has become one of the malignant tumors that threaten the health of our people the most. Radiation therapy is to damage and kill tumor cells by depositing energy and generating free radicals in tumor tissues through ionizing radiation. be guaranteed. [0003] Transforming growth factor-β1 (TGF-β1) plays an important role in regulating the homeostasis of cells and tissues, including signaling pathways such as proliferation, differentiation, migration, cell survival, and angiogenesis. Gene transcription regulation to maintain cell and tissue homeostasis. As a tumor suppressor gene, the normal function of TGF-β1 is usually altered in tumor cells, which is mainly due to the mutation of its receptor or ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4439A61P35/00
Inventor 杨红英黄浅漪蒋友芹赵一凡
Owner SUZHOU UNIV
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