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Use of kif15 inhibitors in the preparation of drugs for treating lung cancer

A technology of therapeutic drugs and inhibitors, which is applied in the field of KIF15 inhibitors and the preparation of lung cancer therapeutic drugs, to achieve the effect of inhibiting the growth of lung cancer tissue, inhibiting the proliferation rate, and changing the cycle distribution

Inactive Publication Date: 2020-04-28
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the treatment of lung cancer is improving with each passing day, its 5-year survival rate is only 14.1%, and 60% of patients die within 1 year after diagnosis

Method used

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  • Use of kif15 inhibitors in the preparation of drugs for treating lung cancer
  • Use of kif15 inhibitors in the preparation of drugs for treating lung cancer
  • Use of kif15 inhibitors in the preparation of drugs for treating lung cancer

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Experimental program
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Embodiment 1

[0084] (1), material

[0085] Lentiviruses and vectors were purchased from Shanghai Jikai Company; relevant antibodies used in cell function and immunohistochemistry of clinical samples were Proteintech products; B27 and CD133 were purchased from invitrogen; DMEM / F12, RPMI-1640 and fetal bovine serum were purchased from Gibco company; Matrigel matrigel is a product of BD; Hoechst33342 and Annexin v / PI apoptosis detection kits were purchased from Biyuntian Biological Products Company; FACS Calibur flow cytometer was from BD Company of the United States; The company; the inverted microscope is Japan OlympusCK; the laser confocal fluorescence microscope is Germany Leica; H1299, A549 cell lines were purchased from Wuhan University Cell Collection Center.

[0086] (2) Research methods

[0087] 2.1 Screening of specific oncogenes that promote transformation of lung cancer cells

[0088] The oncogene screening platform for promoting lung cancer transformation comes from the Cancer ...

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Abstract

The invention belongs to the field of biological medicine study, and particularly relates to a purpose of a KIF15 inhibitor. Through wide and deep study, the condition that the KIF15 can be used as alung cancer treatment target point is discovered for the first time. The KIF15 inhibitor can achieve the effects of inhibiting the multiplication rate of the lung cancer cells, changing the lung cancer cell period distribution, promoting the lung cancer cell apoptosis and inhibiting the lung cancer tissue growth, so that the lung cancer can be treated; a new direction can be opened for the lung cancer treatment.

Description

technical field [0001] The invention belongs to the field of biomedical research, and in particular relates to the use of KIF15 inhibitors in the preparation of drugs for treating lung cancer. Background technique [0002] Primary bronchial lung cancer (abbreviated as lung cancer) is the malignant tumor with the highest incidence rate in recent years, and its rising rate of incidence rate is also the highest among various tumors. Although the treatment of lung cancer is improving with each passing day, its 5-year survival rate is only 14.1%, and 60% of patients die within 1 year after diagnosis. The diagnosis and prognosis evaluation of lung cancer are related to the formulation of individualized treatment plan, which directly affects the treatment and survival of patients. In the era of functional genomics and proteomics research, the development of molecular pathology, research and diagnosis of diseases from the gene level and gene product-protein level has become the fro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K45/06A61P35/00C12Q1/6886C12Q1/686G01N33/533
CPCA61K45/00A61K45/06C12Q1/686C12Q1/6886C12Q2600/136C12Q2600/158G01N33/533
Inventor 刘子玲姜艳丛晓凤陈晨李智
Owner JILIN UNIV
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