20 results about "Costunolide" patented technology

The invention relates to the field of biological medicine, in particular to a carrier-free nanoparticle which is formed by self-assembly of cyclosporine A and costunolide through intermolecular weak interaction. The invention also provides a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of medicines for treating xerophthalmia. The carrier-free nano eye drops based on the synergistic effect of Chinese and western medicines are used for anti-inflammatory treatment of the xerophthalmia, a new strategy is provided for precise diagnosis and treatment of the xerophthalmia, the problems of single target spot, limited curative effect and the like in traditional treatment are solved, and more efficient inflammation control is expected to be achieved. While the curative effect is improved, the tolerance risk caused by long-term use is reduced, double optimization of the curative effect and safety is realized, and the limitation of traditional single drug treatment is broken through. By adopting the carrier-free nano preparation, the delivery efficiency of the medicine on the ocular surface is effectively improved, the bioavailability is enhanced, powerful support is provided for improving the curative effect of the medicine, and the carrier limitation bottleneck is broken through.

The invention belongs to the technical field of medicines, and provides application of a natural-source compound monomer medicine composition in preparation of medicines for preventing and / or treating pancreatitis. The pharmaceutical composition comprises baicalin, paeoniflorin, geniposide, wogonin, baicalein, albiflorin, tetrahydropalmatine, rhein, wogonin, aloe-emodin, saikoside A, emodin, benzoyl paeoniflorin, chlorogenic acid, costunolide, or a pharmaceutically acceptable salt thereof. Compared with the prior art, the pharmaceutical composition disclosed by the invention has the advantages that the components of the composition are definite and are all natural sources, the safety is good, the pharmaceutical effect has a remarkable synergistic effect, the administration dosage is reduced by about 200 times under the condition that the treatment effect is better than that of a compound traditional Chinese medicine, the administration mode of the compound medicine for treating pancreatitis is innovated, and the pharmaceutical composition is suitable for clinical application. A new scheme is provided for the treatment of the disease.

The invention discloses an application of costunolide in preparation of a medicine for treating and / or preventing a non-alcoholic fatty liver disease. It is found that costunolide can activate an Nrf2-ARE signal channel of a body, liver cell lipid metabolism abnormality is effectively improved from the molecular level, and meanwhile the pathological influence of oxidative damage on liver tissue is remarkably relieved. Experimental data show that the compound has a remarkable intervention effect on NAFLD, a scientific basis is provided for development of a novel liver disease treatment agent due to the unique dual regulation and control mechanism of the compound, particularly, the compound shows an important development prospect in the field of clinical intervention of metabolism-related liver injury, and an innovative solution is provided for NAFLD lacking a special-effect therapy at present.

The invention discloses an esophageal cancer targeting nano-tablet based on a traditional Chinese medicine composition and a preparation method of the esophageal cancer targeting nano-tablet. The targeted nano tablet is prepared from the following refined extracts: a rhizoma paridis total saponin extract, a pseudobulbus cremastrae seu pleiones colchicine derivative extract, a panax notoginseng total saponin extract, a carthamin yellow extract, a thunberg fritillary bulb total alkaloid extract, frankincense-myrrh compound volatile oil, a resin extract and an astragaloside IV extract. The nano-carrier comprises a nano-carrier, a seaweed-laminarin composite extract, a processed rhizoma pinelliae total alkaloid extract and costus root volatile oil, and the costus root volatile oil serves as one of targeting ligands to be used for modifying the nano-carrier. The targeting property is strong: the dual-targeting ligand (costunolide-TOPK affinity peptide) on the surface of the nano-carrier can actively recognize and combine with a specific receptor of esophageal cancer cells, and meanwhile, due to the size (about 100-200 nanometers) of the carrier, the carrier is easy to enrich in tumor tissues through enhanced permeation and retention (EPR) effect, so that the modernization upgrading of the idea of'channel guiding medicine 'is realized.

The application discloses a dehydrocostus lactone derivative, a preparation method and medical application thereof, and belongs to the technical field of chemical synthesis. The dehydrocostus lactone derivative is shown as a general formula I. The compound has certain inhibiting effect on HBsAg and HBeAg, can be used for preparing anti-HBV drugs, and provides more efficient and safe candidate drug molecules for clinical anti-HBV treatment.

This invention provides the application of costunolide in the preparation of a drug for preventing posterior capsule opacification. Costunolide effectively reduces posterior capsule opacification after extracapsular lens extraction (ECLE) and exhibits significant anti-inflammatory and anti-fibrotic effects in both in vitro and in vivo models. Mechanistic studies have identified matrix metalloproteinase 8 (MMP8) as a key downstream effector of costunolide, confirming that costunolide inhibits MMP8 expression, thereby blocking the transformation of lens epithelial cells (LECs) into mesenchymal cells and subsequent fibrotic processes. This lays a solid foundation for developing targeted therapies for posterior cataract, a common surgical complication.

This invention provides a costus root formula granule and its preparation method, relating to the technical field of traditional Chinese medicine formula granules. The preparation method includes the following steps: mixing costus root slices with beta-cyclodextrin and decocting to obtain a costus root extract; drying the costus root extract and then granulating it to obtain costus root formula granules. This invention solves the problem of costus root formula granules produced by existing technologies containing costus root lactone (C... 15 H 20 O2) and dehydroaurolactone (C 15 H 18 The technical problem of low O2 content was solved, and the technical effect of effectively increasing the content of costus lactone and dehydrocostus lactone in costus formula granules was achieved.

The present application provides a weight loss composition, comprising a coptis chinensis composition and costunolide, and a preparation method of the coptis chinensis composition is as follows: mixing coptis chinensis extract with ethyl acetate, reacting for 1-1.5 h, filtering and washing, and drying at low temperature to obtain the coptis chinensis composition. After the polysaccharide and the small-molecule alkaloid component are combined, the stability, solubility and permeability of the alkaloid are influenced to some extent, the oral availability of the alkaloid is enhanced, and the use effect is improved.

The present invention belongs to the field of analysis of traditional Chinese medicine preparations, and specifically relates to a method for determining the contents of seven active ingredients in the classic ancient prescription Xiangsha Liujunzi Decoction. This method utilizes high-performance liquid chromatography (HPLC) under the same experimental conditions to simultaneously separate and determine the contents of liquiritin, apigenin, naringin, hesperidin, nobiletin, costunolide, and dehydrocostuslactone in Xiangsha Liujunzi Decoction. Experimental results demonstrate that the HPLC method established herein for simultaneously determining the contents of multiple different index components in a preparation is simple, rapid, accurate, reliable, and exhibits good repeatability and stability, making it suitable for use as a quality control method for the preparation.

The invention relates to the field of biological medicine, in particular to AS vulnerable plaque treatment nanoparticles and a preparation method and application thereof.The nanoparticles comprise hollow mesoporous manganese dioxide nanospheres, and the manganese dioxide nanospheres are loaded with 5 alpha-hydroxycostus acid and perfluoropentane; the manganese dioxide nanosphere is coated with an M2 type macrophage-liposome hybrid membrane, and VLA-4 is expressed on the M2 type macrophage-liposome hybrid membrane. By means of the scheme, normalization of new vessels in plaques is achieved, then the plaques are stabilized, and the problem that treatment cannot be conducted from the perspective of normalization of the new vessels in the prior art is solved.

A fructus cannabis intestine-moistening pill high performance liquid chromatography fingerprint establishment method relates to the field of medicine, and comprises the following steps: weighing fructus cannabis intestine-moistening pill medicinal material powder, adding methanol, plugging, weighing, soaking, carrying out ultrasonic extraction, cooling, weighing, complementing the weight loss, uniformly shaking, and filtering to obtain a test solution; the method comprises the following steps: weighing an emodin reference substance, a rhein reference substance, a chrysophanol reference substance, a hesperidin reference substance, a costunolide reference substance, a dehydrocostunolide reference substance and a paeoniflorin reference substance, adding methanol to prepare a mixed reference substance solution, and filtering to obtain a reference substance solution; sucking the test sample solution and the reference substance solution, injecting the test sample solution and the reference substance solution into a high performance liquid chromatograph, measuring and recording a chromatogram, importing detection results of the test sample solution and the reference substance solution into fingerprint spectrum software, and generating a reference fingerprint spectrum through data matching. The quality of the fructus cannabis intestine moistening pill can be effectively represented, the quality of the medicine can be comprehensively monitored, and the method has the advantages of being high in stability, high in precision and good in reproducibility.

Disclosed herein are compositions and methods for improving sleep health benefits by providing compositions and carriers. Some embodiments provided include compounds that, for example, administrate therapeutically effective plant extracts. In some embodiments, the plant extract is herba lycopi perforati. In some embodiments, the plant extract comprises a costunolide.

The invention relates to the technical field of organic synthesis, in particular to a method for asymmetrically and semi-synthesizing parsnip lactone or an expanded ring derivative of parsnip lactone. According to the method, through a series of chemical reactions, including a ring closing addition reaction (RCM), an asymmetric alkenyl substitution reaction (AAS) and a ring opening ring closing addition reaction (ROM / RCM), a natural and rich precursor compound costunolide is converted into parsnilolactone or an expanded ring derivative thereof. The method has the characteristics of high efficiency, good selectivity and large-scale production, can provide possibility for large-scale synthesis of the parsnip lactone and the ring-expanded derivative thereof, is widely applied to the fields of drug discovery and treatment, and particularly has important potential in development of antiviral and anticancer drugs.

The invention discloses a nucleic acid-small molecule non-covalent compound as well as a preparation method and application thereof. The method for constructing the nucleic acid-small molecule non-covalent compound based on calculation virtual screening guidance is provided for the first time, and a natural active compound capable of forming the compound with framework nucleic acid with a stable three-dimensional structure through non-covalent binding is rapidly screened out through molecular docking; a trace thermophoresis technology verifies that the prediction method is high in accuracy, and a plurality of nucleic acid-small molecule non-covalent complexes including costunolide-framework nucleic acid complexes are successfully constructed. The method does not need chemical modification on drugs or nucleic acids, and is high in universality. The nucleic acid-small molecule non-covalent complex obtained according to the method disclosed by the invention, especially COS-FNA, shows excellent kidney targeting property and ultrahigh treatment efficacy in a kidney disease model, and provides a brand new universal platform for development of kidney targeting drugs.

Disclosed herein are compositions and methods for improving a sleep health benefit by providing a composition and a carrier. Some embodiments provided include, for example, administering a therapeutically effective compound of a plant extract. In some embodiments, the plant extract is Eupatorium perfoliatum. In some embodiments, the plant extract includes costunolide.

The invention discloses a mass detection method based on substance of rhizoma atractylodis macrocephalae powder, and belongs to the technical field of quality analysis and detection of traditional Chinese medicines. The method mainly comprises the following steps: qualitatively identifying ginseng, bighead atractylodes rhizome, poria cocos, pogostemon cablin, radix aucklandiae, radix puerariae and liquorice by adopting a thin layer chromatography; establishing a fingerprint spectrum by using a high performance liquid chromatography to identify the components in the substance reference of the rhizoma atractylodis macrocephalae powder; a high performance liquid chromatography external standard method is adopted to carry out quantitative analysis on atractylenolide II, costunolide and dehydrocostus lactone in the rhizoma atractylodis macrocephalae powder. Key parameters such as the extract yield, the moisture, the extract and the transfer rate are subjected to system detection. According to the integrated analysis method, through multi-dimensional quality evaluation, the quality stability and the process controllability of the classic famous formula rhizoma atractylodis macrocephalae powder are ensured, and a systematic research basis is provided for standardized development of the compound preparation.

The invention discloses alantolactone spliced oxazinane spirooxindole 3, which is specifically prepared by the following steps: refluxing various substituted isatin, alantolactone and proline in an organic solvent, and carrying out 1, 3-dipole 3 + 2 cycloaddition reaction to generate an intermediate, thereby obtaining the alantolactone spliced oxazinane spirooxindole 3. Then nitrogen atoms in the intermediate are subjected to nitrogen oxidation and rearrangement reaction under the action of an oxidizing agent m-chloroperoxybenzoic acid, the final product alantolactone spliced oxazinane spirooxindole 3 is generated, and the skeleton compound can provide a compound source for biological activity screening and has important application value for medicine screening and pharmaceutical industry. The method is simple and easy to operate, raw materials are cheap and easy to obtain, the method can be carried out in various organic solvents, and the method also has good air stability, wide applicability and good compatibility for various substituent groups. And the skeleton compound has a tumor growth inhibition activity effect on human lung adenocarcinoma cells (A549).

The invention provides a novel eudecane-guaiane sesquiterpene dimer as shown in a structural formula as well as a pharmaceutical composition, a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method provided by the invention comprises the following steps: by taking 6 different structures of cinemanane lactone as raw materials, carrying out Diels-Alder reaction / deprotection on the raw materials and guaiane dienes to prepare 6 cinemanane-guaiane sesquiterpene dimers, and further carrying out structural modification to obtain 6 derivatives; or preparing a germacane-guaiane dimer by taking costunolide as a raw material, and further performing intramolecular cyclization to obtain 15 eudecane-guaiane sesquiterpene dimers. The eudecane-guaiane sesquiterpene dimer provided by the invention has inhibitory activity on human hepatoma cell lines HepG2, Huh7 and SK-Hep-1, can form a pharmaceutical composition with a pharmaceutically acceptable carrier, and can be used for preparing anti-hepatoma drugs.

The present application provides a costus root extract, a preparation method thereof and an application thereof in preventing hair loss. The costus root extract contains costunolide and dehydrocostus lactone, and is obtained by supercritical fluid extraction with costus as raw material. The costus root extract can inhibit the opening of TRPV3 channel, reduce Ca 2+ inflow, promote hair growth and ORS cell proliferation, and achieve the effect of preventing hair loss.

Disclosed herein are compositions and methods for improving sleep health benefits by providing a composition and a carrier. Some embodiments provided include, for example, administering a therapeutically effective compound of a plant extract. In some embodiments, the plant extract is Eupatorium perfoliatum. In some embodiments, the plant extract includes costunolide. JPEG2025539362000027.jpg28170