59 results about "Costunolide" patented technology

The invention discloses an oil emulsion containing banksia rose oil and its preparing process, wherein the emulsion comprises rich costunolide and dehydrogenated costuslactone. The invention also provides its use in preparing medicament for the treatment of endotoxemia caused by various reasons.

The invention discloses an antibacterial nano emulsion of a Chinese herbal medicine composition and a preparation method thereof. The Chinese herbal medicine composition comprises at least two of ligustilide, 3-butylidenephthalide, cinnamyl aldehyde, 4-cumaric acid, costunolide, dehydrocostus lactone and eugenol, and the antibacterial nano emulsion is prepared from the Chinese herbal medicine composition. In the manner, the Chinese herbal medicine composition provided by the invention is from natural Chinese herbal medicines, and is small in toxic and side effect, the antibacterial spectrum property of the Chinese herbal medicine composition is increased by synergistic interaction of combination, and the antibacterial nano emulsion can be effectively used for preparing medicaments or cosmetics for treating or relieving escherichia coli, staphylococcus aureus, candida albicans and the like. The antibacterial nano emulsion disclosed by the invention is simple in preparation method, and can be applied to the medicaments or cosmetics at a large scale.

The invention discloses a quality control method for eight-flavor agilawood preparations, which belongs to the technical field of medicines. Existing quality standards of eight-flavor agilawood are correspondingly improved, and based on original quality standards, an authentication method with high specificity for costustoot, myrobalan, fructus choerospondiatis and frankincense is added, and a content determination method for gallic acid, dehydrodiisoeugenol, costunolide and dehydrocostus lactone is added. Precision, stability, specificity and sensitivity of the quality control method are all higher than those of the original quality standards of eight-flavor agilawood pills, and quality safety, uniformity, stability, effectiveness and controllability of products are further ensured.

The invention provides a method of extracting and separating costunolide and dehydrocostuslactone. High speed countercurrent chromatography is adopted for separation. High speed countercurrent separation study is carried out on costunolide and dehydrocostuslactone in radix vladimiriae for the first time. according to the selected three-element system, quick layering can be carried out within 15 seconds, the stationary phase retention rate is high, although few solvent varieties are provided, the above two components can be effectively separated, and a high-purity target compound is obtained; and in addition, as petroleum ether and ethanol with minimal toxicity are adopted, the separation can be finished within 3 hours, the use amount of an organic solvent is little, the environment is little polluted, and influences on health of an operator are reduced.

The present invention relates to anti-cancer active component of Huaiqing chrysanthemum and its separation and purification method. Its anti-cancer compound includes 9 beta-acetyl-costunolide (CP-C) whose molecular formula is C17H22O4 and 9 beta-acetyl-parthenclide (CP-I) whose molecular formula is C17H22O5. Said invention also provides the concrete steps for separation and purification of said anti-cancer components, and discloses three anti-cancer active components of CP-B, CP-C and CP-D.

The invention discloses a pharmaceutical composition, a preparation method and a quality control method. The pharmaceutical composition of the invention is composed of pharmaceutical raw materials such as costustoot, villous amomum fruit, largehead atractylodes rhizome, tangerine peel, Indian buead, pinellia tuber (prepared), nutgrass galingale rhizome, immature bitter orange, jave amonum fruit, officinal magnolia bark, cablin potchouli herb and liquoric root; the prepration method is that: the pinellia tuber and fresh ginger take ethanol as solvent for immersion, and colation is used as standby; the costustoot, the villous amomum fruit, the largehead atractylodes rhizome, the tangerine peel, the immature bitter orange, the jave amonum fruit, the officinal magnolia bark and the cablin potchouli herb use the distillation method for extracting volatile oil, water solution after the distillation is collected in an another container; the medicine residues and other three medicines of Indian buead and the like, as well as Chinese date are decocted by adding water, the filtration is carried out, filtrate and the water solution are merged and concentrated to the relative density of 1.10, the mixture is cooled, ethanol is added, supernatant liquid is poured and taken, the filtration is carried out, the filtrate is merged with the filtrate, the ethanol is recycled, clear paste is obtained by concentration, the clear paste is taken for preparing granules, the volatile oil is added, and the pharmaceutical composition can be obtained by even mixing. The preparation method adopts high performance liquid chromatography to carry out the content measurement of costunolide. The pharmaceutical composition of the invention has significant effects of warming spleen and stomach and regulating stomach.

The invention discloses an alpha-tubulin inhibitor and application thereof. The active ingredients of the alpha-tubulin inhibitor consist of effective quantities of at least one lactone compound of alantolactone, isoalantolactone, dihydro-alantolactone, dehydrocostunolide lactone, costunolide and dihydro-costunolide. The alpha-tubulin inhibitor disclosed by the invention can obviously inhibit alpha-tubulin and the mRNA (Messenger Ribonucleic Acid) level thereof, can inhibit the forming of spindles, block the cell cycle in the G2 / M period, induce cell apoptosis and the like, can effectively inhibit the tumor growth speed, can obviously inhibit growth of various tumor cells, particularly has an obvious effect on melanoma, can be expected to be used for preparing medicament preparations for resisting tumors and has wide application prospect, wherein the tumors comprise lung cancer, pancreatic cancer, prostatic cancer, neuroblastoma, melanoma and breast cancer.

The invention discloses a method for preparing a common vladimiria root and fructus amomi and six-monarch drug preparation. The common vladimiria root and fructus amomi and six-monarch drug preparation is mainly prepared from common vladimiria root, fructus amomi, radix codonopsis, fried rhizoma atractylodis macrocephalae, poria cocos, radix glycyrrhizae preparata, tangerine peel and ginger processed pinellia. Through the method disclosed by the invention, according to properties of all drugs in a prescription of the common vladimiria root and fructus amomi and six-monarch drug preparation, and functions of the drugs in the formula, a specific process for preparing the common vladimiria root and fructus amomi and six-monarch drug preparation and parameters are improved, so that effective component costunolide of common vladimiria root can be easily measured, and the content of measured costunolide is high, therefore the preparation is more refined, has a more obvious drug effect and has a good clinical effect.

The invention relates to a method for preparing parthenolide, and in particular relates to a method for synthesizing parthenolide by using costunolide as a raw material through the following reaction steps in the specification.

The invention relates to a costunolide derivative and a pharmaceutical composition, a preparation method and uses thereof, belongs to the technical field of medicines, particularly relates to a formula (I) compound and the medicine composition, the preparation method and the uses thereof, and particularly relates to the uses of the formula (I) compound (I) for treatment of rheumatoid arthritis and cancer.

The invention relates to a costunolide-containing traditional Chinese medicine composition for treating gastrointestinal diseases and a preparation method thereof. The traditional Chinese medicine composition is prepared from basic medicines and other medicines, wherein, the basic medicines comprise the following components: costunolide, naringin, santalol, chrysophanol, artificial musk, ligustrazine, croton oil and polysaccharides from Chinese red dates. The traditional Chinese medicine composition is mainly used for clinically treating diseases such as acute diarrhea, irritable bowel syndrome and the like.

The invention discloses a method for extracting, separating and purifying costunolide and dehydrocostus lactone from elecampane, and relates to the technical field of extracting, separating and purifying costunolide and dehydrocostus lactone. With an elecampane medicinal material as a raw material, the method disclosed by the invention comprises the following steps: (1) extracting sesquiterpene lactone in the elecampane; (2) separating and analyzing the sesquiterpene lactone in the elecampane; (3) separating and purifying the sesquiterpene lactone in the elecampane; and (4) detecting the purity of the compound and verifying the structure. Semi-preparative high performance liquid chromatography is used for separating and extracting, the mobile phase is methanol-water, and two components with high purity are obtained, which are respectively costunolide and dehydrocostus lactone as shown in verification. The process flow is environmentally friendly, free of severe harm to the environment and low in comprehensive cost.

The invention provides a method for extracting total lactones from costus root by a CO2 supercritical extraction technology and a quality control method thereof. In the invention, the extraction pressure is 10-25MPa, the extraction temperature is 25-40 DEG C, and the extraction time is 2-4 hours, and analysis is carried out at an air pressure of 5-6MPa and a temperature of 34-40 DEG C. The method solves the disadvantages of the conventional extraction process that the operating temperature is relatively high, thermosensitive substance is easy to be oxidized and dissipated, high boiling point substance is not easy to be fully extracted, the yield is low, etc. In an extract of the invention, the content of dehydrocostus lactone is higher than 20%, and the total content of costundide and dehydrocostus lactone is higher than 50%.

The invention provides a Radix Aucklandiae reference extract product, and a preparation method and an application thereof. The preparation method comprises the following steps: respectively extractingbatches of Radix Aucklandiae medicinal material powders multiple times to obtain Radix Aucklandiae extracts in batches, and blending the Radix Aucklandiae extracts in batches to obtain the Radix Aucklandiae reference extract product. The preparation method of the Radix Aucklandiae reference extract product has the advantages of simplicity in operation, low cost, good repeatability and high extraction rate; and the Radix Aucklandiae reference extract product is prepared through the preparation method, so the consistence of the Radix Aucklandiae reference extracts in different batches is ensured, and the Radix Aucklandiae reference extract product has the advantages of stable and uniform properties, and convenience in use; the total content of costunolide and dehydrocostus lactone in the reference extract product finally obtained through the preparation method of the Radix Aucklandiae reference extract product is not less than 3.5% and not more than 9.0%, and the water content of the product is not more than 5.0%; and the thin-layer chromatography fingerprint and the HPLC fingerprint of the reference extract product are correspondingly consistent to those of a certified product Radix Aucklandiae medicinal material.

The invention provides application of costunolide in preparation of anti-hepatic fibrosis drugs and belongs to the technical field of medicines. The anti-hepatic fibrosis drugs are prepared through the costunolide, the usage of the costunolide is increased, and meanwhile the kind of the anti-hepatic fibrosis drugs is enriched. According to the record of the embodiment, the costunolide can restrainexpression of hepatic fibrosis main markers in TGF-beta1 induced LX-2 cells on mRNA and protein levels and can restrain the level of BDL induced hepatic fibrosis rat serum ALT / AST / ALP and expressionof hepatic tissue fibrosis markers on the mRNA and protein levels, and accordingly BDL induced rat hepatic fibrosis is restrained; and meanwhile, through the costunolide, the BDL induced rat hepatic pathologic structure can be further improved, and the collagen deposition situation in the BDL rat hepatic tissue is obviously relieved.

An extraction method for costunolide comprises the following steps of choosing micheliamacclurel velamen as a raw material, drying and smashing; extracting 2 to 4 times with 95% of ethanol in reflux mode, combining extraction liquid and decompressing and concentrating to obtain coarse extractum; taking the dried coarse extractum to perform normal-pressure silica gel column chromatography, sequentially choosing petroleum ether - ethyl acetate of 10:1 and 5:1 as eluant to perform gradient elute, using thin-layer chromatography (TLC) to detect received liquid in all test tubes, adopting the elutant of 10:1 to elute a first spot material clean from a chromatography column, using the elutant of 5:1 to continue eluting, receiving a second spot material, confirming that no spot exists through TLC detection, finishing the column chromatography, combining the received liquid, and concentrating the received liquid to obtain white flaky crystal, namely the costunolide. The extraction method uses the micheliamacclurel velamen as the raw material to prepare monomer costunolide and is reasonable, convenient in operation, easy to obtain the raw material and capable of manufacturing costunolide monomers.

The present invention relates to a pharmaceutical composition containing, as active ingredients, epitulipinolide and costunolide extracted from the bark of Liriodendron tulipifera. More specifically, the present invention relates to a pharmaceutical composition for treating the gastrointestinal tract, the composition containing, as active ingredients, epitulipinolide and costunolide, which are the active ingredients of the extract from the bark of Liriodendron tulipifera, and to the use thereof as a therapeutic agent for gastrointestinal diseases.

The invention relates to the medicinal field, and concretely discloses a costustoot pharmaceutical composition and a medicinal application. The pharmaceutical composition of the present invention is composed of costunolide and dehydrocostus lactone; and the invention also discloses a costustoot volatile oil and a medicinal preparation, and the application of the costustoot volatile oil and the medicinal preparation by being taken as antitumor drugs. In the pharmaceutical composition, the volatile oil and the medicinal preparation, costunolide and dehydrocostus lactone have substantial synergism, the toxic and side effects are small, the pharmaceutical composition, the volatile oil and the medicinal preparation have good clinic application prospect, the preparation method is simple, the cost is low, and the pharmaceutical composition, the volatile oil and the medicinal preparation are suitable for requirements of industrial production.

The invention provides a composition with the effect of improving acute gastric mucosal injury. The composition is composed of 3 parts by weight of costunolide and 0.7-12 parts of dehydrocostus lactone. The composition of the invention can improve gastric mucosal injury, prevent acute gastric mucosal injury, significantly reduce the level of TNF-alpha, NF-kappaB, NO, iNOS and MDA in gastric mucosal injury, significantly increase the level of SOD and PCNA, and promote the healing of mucosal ulcer. When the proportion of components of the compositions is 3:1, the levels of proinflammatory factors, NO, iNOS, oxidative stress factors and PCNA are significantly affected (p is less than 0.001). The composition has a good application prospect.

The invention discloses a quality detection method for an intestines and stomach easing capsule. In the formula, the intestines and stomach easing capsule consists of 300g of tsaoko amomum fruit, 300g of elecampane, 600g of jatamans valeriana rhizome, 600g of geranium strictipes knuth and 400g of rhizoma polygoni paleacei, and the raw materials are prepared into the capsule. The quality detection method for the intestines and stomach easing capsule comprises the steps of identification and content measuring; the content measuring comprises the following steps: firstly, the experiment of chromatograph condition and system application; secondly, the preparation of reference substance solution; thirdly, the preparation of test substance solution; and fourthly, measuring. In the quality detection method for the intestines and stomach easing capsule, the content detecting item is added, one of the main ingredients, namely costundide, is measured by adopting the high performance liquid chromatography, the method is made after a plurality of tests, and is re-checked by foodstuff and drug control institute in Yunnan province, In the method, the operation is simple and convenient, the specificity is strong and the repeatability is good, so that the quality control and test is safer and more effective.

The invention relates to a costunolide-containing traditional Chinese medicine composition for treating gastrointestinal diseases and a preparation method thereof. The traditional Chinese medicine composition is prepared from basic medicines and other medicines, wherein, the basic medicines comprise the following components: costunolide, naringin, santalol, chrysophanol, artificial musk, ligustrazine, croton oil and polysaccharides from Chinese red dates. The traditional Chinese medicine composition is mainly used for clinically treating diseases such as acute diarrhea, irritable bowel syndrome and the like.

The present invention relates to an improved dosage form containing, as active ingredients, epitulipinolide and costunolide extracted from the bark of Liriodendron tulipifera and, more specifically, to a dosage form for treating the gastrointestinal tract, the dosage form containing, as active ingredients, epitulipinolide and costunolide, which are the active ingredients of the extract from the bark of Liriodendron tulipifera.

The invention provides costunolide, dehydrogenized costunolide, and application of a derivative thereof in preparing a protective medicine for preventing and treating anoxic cardiac muscle. Anti-myocardial anoxia functions of the costunolide and the dehydrogenized costunolide are researched through an atmospheric pressure airtight anoxia experiment and acute decompression anoxia model, the resultshows that the costunolide and the derivative dehydrogenized costunolide have an anti-anoxia function, and an action mechanism can be realized through antioxidant stress injury. The costunolide can protect the activity of SOD and CAT in anoxia mice cardiac muscle tissues, enhance an anoxia body brain ROS and free radical scavenging capacity, and reduce MDA, H2O2 and OH levels in mice cardiac muscle caused by ROS after anoxia so as to achieve the effect on resisting myocardial anoxia.

The invention discloses a liver cancer resistant health care product containing costunolide. The health care product comprises following components in percentage by weight: 50 to 70% of costunolide, 7.5 to 12.5% of walnut bark extract, 7.5 to 12.5% of toad extract, 7.5 to 12.5% of croton seed extract, and 7.5 to 12.5% of radix zanthoxyli extract. Innovatively, costunolide is taken as the main rawmaterial of the liver cancer resistant health care product; other traditional Chinese medicines are taken as auxiliary materials to enhance the curative effect; and the main raw material and auxiliarymaterials are blended to form the health care product capable of preventing liver cancer. Provided costunolide composition can obviously inhibit the reproduction of human liver cancer cells, has a good curative effect, solves the problems that in chemical therapy and chemically synthesized drugs, the cytotoxicity and side effect are severe, the cost is high, and the relapse rate is high, and improves the health and life quality of patients, moreover, the raw materials are easily available, and references are provided for further research and clinical application.

The invention discloses a costus root essential oil umbilical mat and a preparation method thereof. The umbilical mat comprises packing, wherein the packing is prepared from an active component and an auxiliary material at the weight ratio of 1 to (1-50); the active component is costus root essential oil; the costus root essential oil contains 30wt%-80wt% of costunolide and dehydrocostus lactone; and the auxiliary material is active silica gel and / or active alumina powder. The method comprises the following steps: adsorbing the costus root essential oil on the active silica gel or active alumina; and preparing the umbilical mat to be fixed on weak skin parts such as an umbilical region and umbilicus periphery. The adsorption capacity of silica gel or aluminum oxide for the costus root essential oil is reduced by using the moisture volatilizing due to skin sweating, thus the costus root essential oil is released; volatilization of the costus root essential oil is further promoted by using the heat caused by moisture adsorption employing the silica gel or aluminum oxide; the drug effect of the costus root essential oil is achieved; and the umbilical mat disclosed by the invention can play a therapeutic or supportive therapeutic efficacy on the diseases such as abdominal pain, abdominal distension and gastrointestinal dysfunction.

The invention provides a radix aucklandiae extract microemulsion as well as a preparation method and an application thereof. The radix aucklandiae extract microemulsion provided by the invention is prepared from a radix aucklandiae extract, isopropyl myristate, Tween 80, diethylene glycol monoethyl ether and deionized water. The invention also provides the preparation method of the radix aucklandiae extract microemulsion, which comprises the following steps: 1) proportionally weighing isopropyl myristate, Tween 80, diethylene glycol monoethyl ether, deionized water and the radix aucklandiae extract to prepare a suspension; and 2) uniformly stirring the suspension obtained in the step 1) to obtain the microemulsion. In the microemulsion provided by the invention, the transdermal rates of costunolide and dehydrocostunolide are obviously improved, and compared with an aqueous solution of the radix aucklandiae extract, the permeation enhancing ratio of costunolide and dehydrocostunolide ofthe radix aucklandiae extract microemulsion is obviously improved.

The invention discloses a quality control method of Bawei agarwood preparation, which belongs to the technical field of medicine. The present invention improves the quality standards of the existing Bawei Chenxiang pills accordingly, and adds a more specific identification method for woody, myrobalan, jujube, and frankincense on the basis of the original quality standards; adds gallic acid, dehydrodi The content determination method of isoeugenol, coyneolide and dehydrocoyneolide, the precision, stability, specificity and sensitivity of this method are all improved compared with the original quality standard of Bawei Chenxiang pills, further ensuring The product quality is safe, uniform, stable, effective and controllable.

The invention discloses a pharmaceutical composition for treating hyperosteogeny and a preparation method thereof. The pharmaceutical composition of the invention is composed of garcinia biflavone, Guangxi bermudagrass, flicker grass, woody hydrocarbon lactone, anisodine, Lycoperionine is the raw material medicine, which is prepared in proportion, and can be made into various dosage forms according to the conventional preparation process, and has remarkable curative effect in treating hyperosteogeny.

The present invention relates to a compound as represented by formula (I), pharmaceutical composition thereof as well as preparation method and uses thereof, in particular to the uses of the compound as represented by formula (I) for treating rheumatoid arthritis and cancers.

The present invention relates to an improved dosage form containing, as active ingredients, epitulipinolide and costunolide extracted from the bark of Liriodendron tulipifera and, more specifically, to a dosage form for treating the gastrointestinal tract, the dosage form containing, as active ingredients, epitulipinolide and costunolide, which are the active ingredients of the extract from the bark of Liriodendron tulipifera.