Implantable cyanoacrylate medical adhesive and application thereof

A technology of cyanoacrylate and n-butyl cyanoacrylate, which is applied in the field of implantable cyanoacrylate medical adhesives, can solve the problem of poor stability of α-butyl cyanoacrylate, safety of cracking additives, and flexibility Poor performance and other problems, to achieve the effect of controllable curing speed, prolonging the curing time, and curing and forming a soft film

Pending Publication Date: 2021-12-24
ENOVE PRECISION PLASTICS CATHETER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, α-cyanoacrylate compound adhesives have been widely used in the medical field, but there are still problems such as high curing exotherm, poor flexibility, cracking after bonding, and additive safety.
When α-butyl cyanoacrylate is used as an embolizing agent for endovascular embolization of cerebral arteriovenous malformations, it may cause angioedema, lead to vasospasm, and cause complications
Moreover, the stability of α-butyl cyanoacrylate is not ideal, and there is a risk of recanalization after embolization
In addition, the biggest disadvantage of α-cyanoacrylate embolic agents is the problem of "sticky tube", which is also a common problem of all adhesive embolic materials.
Due to the limitations of α-cyanoacrylate when used alone, it can not meet the clinical needs well, so it is urgent to develop a long curing time, less heat generated by curing, high bonding strength and good biocompatibility. Cyanoacrylate Medical Adhesive

Method used

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  • Implantable cyanoacrylate medical adhesive and application thereof
  • Implantable cyanoacrylate medical adhesive and application thereof
  • Implantable cyanoacrylate medical adhesive and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Composition: 37g of n-butyl α-cyanoacrylate, 12g of plasticizer tributyl citrate, 226mg of hydroquinone as a polymerization inhibitor, 2g of polyethylene glycol 400 as a toughening agent, and 706mg of p-toluenesulfonic acid as a stabilizer. Accurately weigh the above-mentioned substances, mix and sterilize evenly by stirring to obtain the medical glue of the present invention. Existing commercially available medical adhesive A combination: the main component is n-butyl α-cyanoacrylate, the plasticizer is dioctyl phthalate, the polymerization inhibitor is sulfur dioxide, and the stabilizer is p-toluenesulfonic acid.

experiment example

[0043] Cure speed test:

[0044] Method: Add 80ml of 0.3g / L sodium bicarbonate solution to a plate with a diameter of 140mm, absorb the medical glue with a dropper, drop a drop at a place 5cm above the liquid surface, and record the curing time of the glue.

[0045] Data: The curing time of the medical adhesive in this case is 15s, and the cured film is soft and not easy to break ( figure 1 ), there is no foreign body when it is lifted and bent, indicating that the patient's foreign body sensation is weakened after implantation. In the comparison experiment, the polymerization inhibitor used in the existing commercially available A medical adhesive is sulfur dioxide, and its curing time is 6-8s, and the cured film is easy to break ( figure 2 ), the bending part is hard and has a foreign body feeling.

[0046] Curing Exotherm Test:

[0047] Method: α-cyanoacrylate medical glue should release heat while curing. When the heat release is the highest, the local tissue will feel...

Embodiment 2 Embodiment 6

[0060] The following table 2 is used to prepare according to the method of Example 1, wherein the plasticizers used in Examples 2 to 6 are tributyl citrate, acetyl tributyl citrate, triethyl citrate, and acetyl tributyl citrate , triethyl citrate, the polymerization inhibitor glacial acetic acid used in embodiment three, all the other material types are identical with embodiment 1.

[0061] Table 2: Components and performance test results of Embodiment 2 to Embodiment 6

[0062]

[0063]

[0064] performance test results

[0065]

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Abstract

The invention relates to an implantable cyanoacrylate medical adhesive and an application thereof. The medical adhesive comprises the following components in parts by mass: 60 to 80 parts of cyanoacrylate, 10 to 30 parts of a plasticizer, 0.3 to 5 parts of a polymerization inhibitor, 0 to 5 parts of a flexibilizer and 0 to 5 parts of a stabilizer. The addition amounts of the flexibilizer and the stabilizer are not 0 at the same time. Compared with the prior art, the medical adhesive has the controllable curing speed, low heat release during bonding, high bonding strength, capability of being injected into veins to cure and block blood vessels and relieve varicosity, soft cured film and capability of reducing foreign body sensation.

Description

technical field [0001] The invention relates to the field of medical polymer materials, in particular to an implantable cyanoacrylate medical glue and its application. Background technique [0002] In the structure of α-cyanoacrylate monomer, the electron-withdrawing group cyano group and ester group are connected to the same carbon atom, so that the monomer has strong electrophilicity, and in the presence of trace anions, it can undergo rapid Intermolecular polymerization produces adhesive force, so that the two ends of the ruptured and damaged tissue are bonded together. The polymerization process can be carried out at room temperature without heating and pressure. The cured α-cyanoacrylate will be degraded into formaldehyde and cyanoacetic acid in the body, and will be excreted with metabolism. [0003] In recent years, α-cyanoacrylate compound-based adhesives have been widely used in the medical field, but there are also problems such as high curing exotherm, poor flexi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/04
CPCA61L24/046A61L24/001A61L24/00A61L2430/36C08L71/02
Inventor 解永树王云云李成杰李其兆秦晓鹏魏先锋
Owner ENOVE PRECISION PLASTICS CATHETER
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