Photo-thermal chemotherapy bone repair material and preparation method of tissue engineering scaffold

Abstract

The invention discloses a photo-thermal chemotherapy bone repair material and a preparation method of a tissue engineering scaffold. The bone repair material includes an oil-soluble high-molecular material, bio-ceramic powder, an oily solvent, a water-soluble bioactive material, water, an emulsifier, a chemotherapy medicine, and a photo-thermal agent. The preparation method includes: according tothe bone repair material, preparing a W / O emulsion, and sending the W / O emulsion to an ink cartridge of a printer as printing ink; establishing a tissue engineering scaffold three-dimensional model onCAD software, setting printing parameters, regulating the temperature of a shaping chamber in the printer, and printing a tissue engineering scaffold prefabricated member, so that when solvent in theprefabricated member is volatilized naturally, a finish product of the tissue engineering scaffold is formed. The tissue engineering scaffold has good mechanical character, can simulate bone tissue structure, has excellent bone guidance and bone conduction and excellent photo-thermal effect and is toxic-free, and can promote recovery of massive bone defects caused by bone tumor resection.

Description

technical field [0001] The invention belongs to the technical field of biomaterials and regenerative medicine, in particular to a preparation method of photothermal chemotherapy bone repair material and tissue engineering scaffold. Background technique [0002] A variety of materials are currently on the market for inducing bone repair after bone tumor resection. The 3D printed scaffolds made of tricalcium phosphate, hydroxyapatite and bioglass have good mechanical properties (high compressive strength but brittle) and osteoconductivity after sintering, but lack of osteoconductivity. Although hydrogel-based 3D printed scaffolds have good bioactivity, their mechanical properties are too poor and there is no biomimetic bone tissue structure. On the other hand, in order to prevent the recurrence of residual tumor cells around the resected tissue, a variety of photothermal preparations such as graphene oxide, ferric oxide, etc., as well as chemotherapeutic drug molecules are de...

AI Technical Summary

Problems solved by technology

Although hydrogel-based 3D printed scaffolds have good bioactivity, their mechanical properties are too poor and there is no biomimetic bone tissue structure

On the other hand, in order to prevent the recurrence of residual tumor cells around the resected tissue, a variety of photothermal preparations such as graphene oxide, ferric oxide, etc., as well as chemotherapeutic drug molecules are deposited on the surface of the stent or loaded inside the stent to improve the ability of the stent to pass through photothermal and Chemotherapy has the ability to kill tumors, but most photothermal preparations are highly toxic and difficult to degrade, while a small number of non-toxic photothermal preparations such as black phosphorus have low stability

For sinterable bioceramics, photothermal preparations and chemotherapeutic drugs cannot be loaded on the inside of the stent in situ, and can only be deposited on the surface, which also severely limits the long-term anti-cancer ability of the stent

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