Photo-thermal chemotherapy bone repair material and preparation method of tissue engineering scaffold

A technology for tissue engineering scaffolds and bone repair, applied in tissue regeneration, medical science, prostheses, etc., can solve the problems of limiting the long-term anti-cancer ability of scaffolds, low stability of non-toxic photothermal preparations, and high toxicity of photothermal preparations , to achieve good new bone induction and regeneration ability, excellent tumor cell killing effect, and excellent bone conduction effect

Inactive Publication Date: 2018-12-18
王翀
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hydrogel-based 3D printed scaffolds have good bioactivity, their mechanical properties are too poor and there is no biomimetic bone tissue structure
On the other hand, in order to prevent the recurrence of residual tumor cells around the resected tissue, a variety of photothermal preparations such as graphene oxide, ferric oxide, etc., as well as chemotherapeutic drug molecules are deposited on the surface of the stent or loaded inside the stent to improve the ability of the stent to pass

Method used

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  • Photo-thermal chemotherapy bone repair material and preparation method of tissue engineering scaffold
  • Photo-thermal chemotherapy bone repair material and preparation method of tissue engineering scaffold
  • Photo-thermal chemotherapy bone repair material and preparation method of tissue engineering scaffold

Examples

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Embodiment 1

[0041] A photothermal chemotherapy bone repair material, including 90 parts of oil-soluble polymer material, 60 parts of bioceramic powder, 100 parts of oily solvent, 1 part of water-soluble bioactive material, 18 parts of water, 4.5 parts of emulsifier, and 0.6 parts of chemotherapy drug part, 0.6 part of photothermal preparation. The mass-volume ratio of the photothermal preparation to the oily solvent is greater than 0 and less than 0.01g / ml; the mass-volume ratio of the bioceramic powder to the oil-soluble polymer material is 1-2.5; the mass-volume ratio of the water-soluble bioactive material to water is greater than 0 is less than or equal to 0.05 g / ml; the mass volume ratio of emulsifier to water is greater than 0 and less than 0.05 g / ml, and the mass volume ratio of chemotherapeutic drugs to water or oily solvent is greater than 0 but less than 0.05 g / ml.

[0042] Wherein, the oil-soluble polymer material is polylactic acid-polytrimethylene carbonate PLA-PTMC, the phot...

Embodiment 2

[0051] A photothermal chemotherapy bone repair material, including 30 parts of oil-soluble polymer material, 60 parts of bioceramic powder, 100 parts of oily solvent, 0.1 part of water-soluble bioactive material, 20 parts of water, 1 part of emulsifier, and 0.9 parts of chemotherapy drug 1 part of chemotherapy drug, 5 parts of photothermal preparation. The mass-volume ratio of the photothermal preparation to the oily solvent is greater than 0 and less than 0.01g / ml; the mass-volume ratio of the bioceramic powder to the oil-soluble polymer material is 1-2.5; the mass-volume ratio of the water-soluble bioactive material to water is greater than 0 is less than or equal to 0.05 g / ml; the mass volume ratio of emulsifier to water is greater than 0 and less than 0.05 g / ml, and the mass volume ratio of chemotherapeutic drugs to water or oily solvent is greater than 0 but less than 0.05 g / ml.

[0052] Among them, the oil-soluble polymer material is polylactic acid-glycolic acid (PLGA),...

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Abstract

The invention discloses a photo-thermal chemotherapy bone repair material and a preparation method of a tissue engineering scaffold. The bone repair material includes an oil-soluble high-molecular material, bio-ceramic powder, an oily solvent, a water-soluble bioactive material, water, an emulsifier, a chemotherapy medicine, and a photo-thermal agent. The preparation method includes: according tothe bone repair material, preparing a W/O emulsion, and sending the W/O emulsion to an ink cartridge of a printer as printing ink; establishing a tissue engineering scaffold three-dimensional model onCAD software, setting printing parameters, regulating the temperature of a shaping chamber in the printer, and printing a tissue engineering scaffold prefabricated member, so that when solvent in theprefabricated member is volatilized naturally, a finish product of the tissue engineering scaffold is formed. The tissue engineering scaffold has good mechanical character, can simulate bone tissue structure, has excellent bone guidance and bone conduction and excellent photo-thermal effect and is toxic-free, and can promote recovery of massive bone defects caused by bone tumor resection.

Description

technical field [0001] The invention belongs to the technical field of biomaterials and regenerative medicine, in particular to a preparation method of photothermal chemotherapy bone repair material and tissue engineering scaffold. Background technique [0002] A variety of materials are currently on the market for inducing bone repair after bone tumor resection. The 3D printed scaffolds made of tricalcium phosphate, hydroxyapatite and bioglass have good mechanical properties (high compressive strength but brittle) and osteoconductivity after sintering, but lack of osteoconductivity. Although hydrogel-based 3D printed scaffolds have good bioactivity, their mechanical properties are too poor and there is no biomimetic bone tissue structure. On the other hand, in order to prevent the recurrence of residual tumor cells around the resected tissue, a variety of photothermal preparations such as graphene oxide, ferric oxide, etc., as well as chemotherapeutic drug molecules are de...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/18A61L27/50A61L27/12
CPCA61L27/12A61L27/18A61L27/50A61L27/54A61L2300/412A61L2300/414A61L2300/416A61L2300/45A61L2430/02C08L67/04C08L69/00
Inventor 王翀万健徐若齐梅林谢登辉叶鑫宇朱煌荣赵益涛童庆何智谢晓琼
Owner 王翀
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