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Method for preparing polyelectrolyte composite coating

A technology of polyelectrolyte and composite coating, applied in coating, medical science, prosthesis, etc., can solve the problem that the polyelectrolyte composite film is not very stable, and achieve long-term stability, good degradability and biophase capacitive, osteogenic effect

Inactive Publication Date: 2011-02-02
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, polyelectrolyte composite membranes are not very stable under physiological conditions (completely degraded in 4 to 7 days)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Preparation of RGD cross-linked collagen / sodium hyaluronate polyelectrolyte composite layer

[0020]Dissolve a certain amount of hyaluronic acid in water, add GRGDSPCS-SCPSDGRG to dissolve, and finally add EDC / NHS to dissolve, react for 4 hours, the reaction product is dialyzed for 1 week, and freeze-dried; the reaction product is directly dissolved in water, add xylose, and react 4 hours, dialyzed for one week, and freeze-dried to obtain RGD-grafted sodium hyaluronate with free sulfhydryl groups.

[0021] The sodium hyaluronate and collagen grafted by the RGD were dissolved in 0.1mol / L NaCl solution respectively, and the concentration of both was 1mg / ml; the surface of the implant was sandblasted with large particles, H 2 SO 4 Treat with HCl mixed acid solution for 1 minute, wash the implant surface with a large amount of pure water, then soak the implant in the collagen solution for 10 minutes, wash the implant with deionized water to remove physically ads...

Embodiment 2

[0022] Example 2: Preparation of acid-soluble gelatin / sodium hyaluronate polyelectrolyte composite layer crosslinked by RGD

[0023] The method is the same as in Example 1, except that the collagen is replaced with acid-soluble gelatin (the source of which is porcine, bovine or mouse).

Embodiment 3

[0024] Example 3: Preparation of RGD crosslinked chitosan / sodium hyaluronate polyelectrolyte composite layer

[0025] The method is the same as in Example 1, except that the collagen is replaced by chitosan.

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PUM

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Abstract

The invention provides a method for preparing polyelectrolyte composite coating. Disulfide bonds formed between sulfydryl of RGD specifically crosslink the polyelectrolyte composite coating, as a result, crosslinking of the polyelectrolyte composite coating is realized while RGD is introduced; and in addition, as the disulfide bonds are introduced, the biodegradable property of the final polyelectrolyte composite coating can be provided with in vivo responsiveness. The coating is suitable for surface treatment of titanium radical implants embedded in vivo, can promote adherence proliferation differentiation of bone precursors, can promote early development of ossification around the implants, can realize fast osseointegration between hard tissues and permanent implanted materials and facilitates long-term stability of implanted materials. Polyelectrolytes used in the invention all have fine biodegradability and biocompatibility, the degradation products of the polyelectrolytes can be absorbed by human bodies; and in addition, animal experiments indicate that the polyelectrolyte composite coating can promote osteogenesis of injured parts and can be constructed on the surface of medical pure titanium or titanium alloy implants.

Description

technical field [0001] The invention belongs to the technical field of medical material manufacturing, and relates to a preparation method of a RGD-crosslinked polyelectrolyte composite coating on the surface of a titanium-based implant. The coating can realize rapid osseointegration between hard tissues and permanent implant materials. It also contributes to the long-term stability of the planting material. Background technique [0002] Studies have shown that the interface reaction in the early stage (the first few weeks) after the implant is placed in the body is very important, directly related to the speed and quality of osseointegration, and directly related to the success rate of implant restoration. At present, almost all of the implants used clinically are surface-modified implants with inorganic components on the surface, which have a high success rate of implantation. However, clinically, the period of oral implant treatment is quite long (generally 2-3 months, a...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/06
Inventor 李晓东黄颖
Owner ZHEJIANG UNIV
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