Novel multifunctional mesoporous glass bracket with biological activity as well as preparation method and purpose thereof

A bioactive glass, multifunctional technology, applied in bone implants, medical science, prostheses, etc.

Active Publication Date: 2014-04-16
中科硅诺(太仓)生物材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, to the best of our knowledge, few current bioactive porous scaffolds have "truly" multifunctional properties

Method used

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  • Novel multifunctional mesoporous glass bracket with biological activity as well as preparation method and purpose thereof
  • Novel multifunctional mesoporous glass bracket with biological activity as well as preparation method and purpose thereof
  • Novel multifunctional mesoporous glass bracket with biological activity as well as preparation method and purpose thereof

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Experimental program
Comparison scheme
Effect test

preparation example Construction

[0081] Preparation and Characterization of Copper-Containing Mesoporous Glass Scaffolds

[0082] In a first aspect of the present invention, a multifunctional mesoporous bioactive glass scaffold is provided,

[0083] The bioactive glass support is an amorphous glass structure, and 90% to 99.999% of the macropores are interconnected;

[0084] The bioactive glass scaffold also contains 1 to 15 mol% copper, based on the CuO-CaO-P in the amorphous glass structure 2 o 5 -SiO 2 Calculate the amount of the total substance.

[0085] In a specific embodiment, the porosity of the bioactive glass scaffold is not lower than 85%.

[0086] In a specific embodiment, the mesoporous distribution of the bioactive glass scaffold is 2-9 nm, preferably 5±1 nm.

[0087] In a specific embodiment, the drug release of the bioactive glass stent can be maintained for 3-10 days, preferably 7±1 days.

[0088] In a specific embodiment, the antibacterial efficiency of the bioactive glass scaffold can ...

specific Embodiment approach

[0121] Mix and dissolve P123 and ethanol at a mass ratio of 1: (10-20), mix analytically pure ethyl orthosilicate and ethanol at a ratio of 1: (7-15), and adjust the pH value to 2-4 with hydrochloric acid. Stir well at room temperature for 60±10 minutes, then add calcium nitrate tetrahydrate, triethyl phosphate and copper chloride with different contents (Cu content: 1-15%). After stirring for 3-5 hours, it is used to coat the polyurethane sponge 3-5 times, dried at room temperature for 24 hours, and calcined at 600-750° C. for 3-8 hours.

[0122] By XRD, TEM, SEM and N 2 The phase, mesoporous structure, macroporous structure, specific surface area and mesoporous pore volume of mesoporous glass scaffolds with different copper contents were systematically characterized by means of adsorption-desorption.

[0123] The impregnation, coating, drying, calcination, and usually cooling steps of the present invention can be carried out using equipment and methods conventional in the a...

example 1

[0148] Mix and dissolve P123 and ethanol at a mass ratio of 1:15, mix analytically pure ethyl orthosilicate and ethanol at a ratio of 1:8.7, adjust the pH value to 2 with hydrochloric acid, fully stir at room temperature for 60 minutes, and then add four Calcium nitrate hydrate, and triethyl phosphate and different content of copper chloride (Cu molar content: 0, 1, 2, 5%). After stirring for 5 hours, it was used to coat polyurethane sponge 3 times, dried at room temperature for 24 hours, and calcined at 650° C. for 5 hours.

[0149] Material characterization, vascularization, osteogenesis, drug delivery, and antimicrobial performance studies are then performed, such as Figure 1-13 shown.

[0150] The multifunctionality study of the copper-containing mesoporous glass support has the following conclusions:

[0151] (1) Angiogenesis potential of copper-containing mesoporous glass scaffolds

[0152] The mesoporous glass scaffolds with different copper contents were cultured w...

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Abstract

The invention provides a multifunctional mesoporous glass bracket with biological activity, and the glass bracket with biological activity has a amorphous form glass structure, and 90%-99.999% of macropores are communicated; the glass bracket with biological activity also contains 1-15 mol% of copper, which is based on calculation of total substance amount of the glass bracket with biological activity CuO-CaO-P2O5-SiO2. The invention also provides a preparation method of multifunctional mesoporous glass bracket with biological activity, which employs a sol-gel method to prepare mesoporous glass bracket with biological activity containing different copper contents; the copper-containing mesoporous glass bracket with biological activity has the advantages of blood vessel forming potential, ossification property, medicament deliver and antibacterial property.

Description

technical field [0001] The invention relates to the fields of tissue engineering and material science, in particular to a multifunctional mesoporous bioactive glass for bone repair and a bone tissue engineering support thereof. Background technique [0002] Bone tissue engineering is a technology that uses the principles and methods of engineering and life sciences to regenerate new bone tissue to repair and replace diseased or defective bone tissue, or to enhance its function. [0003] Cells are planted on biomaterial scaffolds, and living tissues are cultured in vivo or in vitro, and then they are implanted into the defect or diseased site to repair the defect or diseased bone tissue. This is one of the ways to use tissue engineering to construct new bone tissue or restore the function of diseased bone tissue. [0004] Treatment of bone defects, especially large bone defects caused by trauma, infection, tumor or genetic malformation remains a major challenge in clinical t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/10A61L27/54A61L27/56A61F2/28
Inventor 吴成铁常江
Owner 中科硅诺(太仓)生物材料科技有限公司
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