10 results about "Aniline Compounds" patented technology

This invention provides a method for preparing 4,1-disubstituted pyrrolo[1,2-a]quinoxaline-1-yl ketone derivatives, belonging to the field of organic synthesis technology. This invention uses 2-(1H-pyrrolo-1-yl)aniline compounds and α-carbonyl acids as reactants, employing only ammonium persulfate as an oxidant. Under metal-free catalysis, a one-pot tandem reaction is carried out to simultaneously complete the cyclization of the pyrrolo[1,2-a]quinoxaline nucleus and the C-1 acylation modification. The substituents at the 4- and 1-positions of the product can be flexibly controlled by changing the α-carbonyl acid with different structures. This method requires no pre-modified substrate, eliminates the need for metal catalysts, avoids the risk of metal residue, and features simplified steps and high functional group compatibility, providing a new green and low-cost route for the synthesis of polysubstituted pyrrolo[1,2-a]quinoxaline ketone derivatives.

This invention provides a method for producing norborneneimide derivatives using a simple manufacturing process and with a high reaction conversion rate. [Solution] A method for producing norborneneimide derivatives, comprising a reaction step of reacting a 5-norbornene-2,3-dicarboxylic acid anhydride represented by the following formula (1) with an aniline compound in the presence of an organic solvent with a boiling point of 120°C or higher. JPEG2026085818000009.jpg48170

This invention provides a method for treating nitrochlorobenzene tar by catalytic hydrogenation to obtain aniline compounds containing chloroaniline and chlorodiphenylamine. This invention utilizes low-value production wastewater to produce chloroaniline and chlorodiphenylamine, which have higher economic value, thus solving the problems of high safety risks and low recovery rates in existing nitrochlorobenzene tar disposal methods.

The present disclosure provides crystalline forms of the compound having formula (I): (I), wherein the crystalline forms are crystalline Forms A, B, C, E, F, and H, each of which is characterized by an X-ray powder diffraction (XRPD) pattern. The present disclosure also provides methods for preparing crystalline forms, in particular Form A. The present disclosure further provides methods of treating various skin disorders using the crystalline forms of the disclosure or a pharmaceutical composition thereof.

The application discloses a preparation method of a phenylacetyl acetic acid compound, relates to the technical field of chemical synthesis, and the synthesis route of the phenylacetyl acetyl acid compound is as follows: an aniline compound connected with five groups of R1, R2, R3, R4 and R5 is used as a raw material, a diazotization reagent is added under acidic conditions to perform a diazotization reaction, a phase transfer catalyst, a copper catalyst and divinyl ketone are added to perform a reaction, and hydrolysis is performed under acidic conditions to obtain the phenylacetyl acetic acid compound; wherein R1, R2, R3, R4 and R5 are each independently selected from F, Cl, Br, -CH3, -OCH3, NO2, -C2H5, -C3H7, -CF3 or H, and are not H at the same time; when one or more of R1, R2, R3, R4 and R5 is F, the rest are not all H; and X is selected from Cl or Br. The raw material prepared by the application is easy to obtain, the operation is simple, the reaction condition is mild, the danger is low, the reaction step is short, the production cost and three waste emissions of enterprises are reduced, and large-scale industrial production can be easily realized.

The application discloses a preparation method of a metal catalyst catalyzed synthesis of 3-boronate aniline, and relates to the field of organic synthesis. The specific reaction steps are as follows: under the condition of inert gas protection, imine (I) and pinacol diboron are used as raw materials, mixed with a certain amount of metal catalyst and ligand, reacted in an organic solvent, and then hydrolyzed with saturated ammonium chloride aqueous solution. After the reaction is completed, the 3-boronate aniline compound shown in structural formula (II) is obtained through the following steps: extracting three times with ethyl acetate, combining the organic phase and removing the solvent under reduced pressure, column chromatography separation and purification. The reaction of the chemical preparation method provided by the application can be carried out under normal pressure and at medium temperature, the operation is simple, the reaction condition is mild, the process condition is stable, the product is easy to purify, the production cost is low, the method is easy to realize in a standard organic synthesis laboratory, the reproducibility is good, and the method is suitable for industrial large-scale production.

To provide a method for producing monobromoaniline, which is extremely useful as an intermediate in manufacture of pharmaceuticals, electronic materials and various functional chemicals.SOLUTION: In a method for producing a compound represented by formula (2), a brominating agent obtained by reacting a halide salt with bromine in water and an organic solvent is reacted with the compound represented by formula (1). (In the formulas, PG is a protective group; each R is independently H, a C1-6 alkyl group, or the like.)SELECTED DRAWING: None

This invention belongs to the field of polyether polyol technology, specifically relating to low-viscosity aniline polyether polyol, its preparation method, and its application. The low-viscosity aniline polyether polyol has a viscosity below 10000 mPa·s, and its raw material components include 5-15 parts of o-toluene diamine, 10-35 parts of aniline compound, 0.05-0.3 parts of alkali metal catalyst, and 30-70 parts of epoxide alkane. The resulting low-viscosity aniline polyether polyol has even lower viscosity, resulting in better operability and applicability in product applications, and exhibits excellent thermal conductivity in the preparation of rigid polyurethane foam products. The preparation method is simple and convenient. The application of the low-viscosity aniline polyether polyol is in the preparation of rigid polyurethane foam.

The application discloses a salt-tolerant aniline high-efficiency degradation and denitrification and phosphorus removal nitrate-reducing bacterium and application thereof, and belongs to the wastewater treatment and microbial technology field. Nitratireductor The strain is sp. AS9, is preserved in the China General Microbiological Culture Collection Center, and has a preservation number of CGMCC No. 36404 and a preservation date of October 30, 2025. The strain has high-salt high-nitrogen and phosphorus high-concentration aniline tolerance, can take aniline as the only carbon and nitrogen source, can efficiently degrade aniline under low, medium and high-concentration aniline conditions, and can simultaneously realize denitrification and phosphorus removal. In particular, the aniline degradation efficiency and denitrification capacity of the strain are more prominent in a high-concentration aniline environment. In addition, the AS9 strain can simultaneously perform nitrification-denitrification denitrification and phosphorus removal reaction, and has great application potential and technical advantages in the treatment of wastewater containing high-salt high-nitrogen and phosphorus aniline compounds.

This invention relates to a photo-initiated method for synthesizing asymmetric azo aromatic compounds and its applications, belonging to the field of organic synthesis technology. A 1-hydroxybenzotriazole compound is deprotonated under alkaline conditions and then undergoes a cleavage reaction under visible light excitation to generate a highly reactive diradical intermediate. This intermediate is unstable and rapidly tautomerizes to a more stable nitrosophenyl anion intermediate. Under aprotic polar solvent conditions, this highly reactive intermediate is proton-quenched to obtain a highly reactive nitrosobenzene intermediate, which subsequently polymerizes with aniline compounds to generate asymmetric azo aromatic compounds. The raw materials are readily available, the synthetic route is short, the process is simple, and the products are easily separated and purified, making it suitable for large-scale synthesis. This provides a new route for the rapid preparation of asymmetric azo aromatic compounds. The synthesized asymmetric azo aromatic compounds exhibit good antibacterial activity and have significant application potential in the control of anthracnose in tea trees.