45 results about "Aniline Compounds" patented technology

This invention provides a benzene-azo group-grafted polyhydroxy graphene oxide-based material and its application in electromagnetic wave absorption. The material is synthesized using aniline compounds and polyhydroxy graphene oxide as raw materials via diazo coupling. The feasibility of the preparation method was verified by spectral characterization, demonstrating the feasibility of impedance matching through covalent grafting of functionalized functional groups. This preparation method is simple, low-cost, and yields high output.

The present invention relates to a novel haloalkyl sulfonanilide compound or a salt thereof, a herbicide composition containing the compound or salt thereof, a method of weed control, including the step of applying the herbicide composition, and a method of producing the compound.

The invention discloses a process for catalytically synthesizing a triazine ultraviolet light absorber based on a nano molecular sieve, which comprises the following steps: preparing raw materials, preparing zeolite and a molecular sieve Y to prepare a nano molecular sieve catalyst, and synthesizing and activating the nano molecular sieve catalyst to obtain the triazine ultraviolet light absorber. The method comprises the following steps: synthesizing a nano molecular sieve catalyst by a sol-gel method, activating the catalyst by removing a template substance through high-temperature calcination, synthesizing the catalyst, adding an aniline compound and an amino compound into a reactor, adding alcohols, ketones and a non-polar solvent at the same time, and reacting at the pressure of 200 DEG C; the nano molecular sieve catalyst is used in the synthesis process, the catalyst is synthesized by a sol-gel method, and is obtained by removing a template substance through high-temperature calcination, and the high specific surface area and the unique pore structure of the nano molecular sieve can provide a larger reaction surface and enhance the contact of reactants.

The invention discloses a multi-mode liquid chromatography filler of ionic liquid hydrogel modified silica gel and preparation and application thereof, and the method comprises the following steps: fully dissolving an ionic liquid hydrogel monomer and a cross-linking agent in a polar aprotic organic solvent, adding silica gel, carrying out ultrasonic treatment, and standing; adding an initiator, stirring, condensing, refluxing, stirring and reacting at 70-80 DEG C in an inert atmosphere; and drying under stirring, centrifugally washing and drying. According to the invention, the problems of single functional group, tedious modification steps, low ligand density and poor high-pressure stability in the existing method are solved. The preparation method is simple and convenient, efficient modification of hydrogel on the surface of silica gel can be achieved, and the prepared liquid chromatography packing has good separation selectivity on nucleoside / basic groups, organic acid compounds, alkaloid, antibiotics, aniline compounds, anion-containing compounds and the like; and chromatographic separation in a hydrophilic chromatographic mode, a hydrophobic chromatographic mode and an ion exchange chromatographic mode can be realized.

The present application provides a phenylacetaldehyde derivative as shown in formula (1), and also provides a preparation method of the phenylacetaldehyde derivative and the use of the phenylacetaldehyde derivative as a color developing agent for detecting aniline compounds. The present application also provides a method for detecting the content of aniline compounds and a method for monitoring the discharge of waste brine in an isocyanate production process. The phenylacetaldehyde derivative provided by the present application has strong color developing ability, and can quickly react and show obvious changes in color even at very low content of aniline compounds. The detection method provided by the present application is simple to operate, does not require expensive detection instruments, has accurate and reliable detection results, has low detection limit, and can also realize online detection and analysis. The monitoring method provided by the present application can collect data at different discharge sites in real time and judge the process operation condition in time, so that the abnormal working condition can be handled in time, the occurrence of downstream accidents can be avoided, the production safety is improved, and the environmental protection is also facilitated.

The application discloses an automatic analyzer for detecting aniline compounds in liquid and a determination method, and realizes automatic and rapid determination of aniline compounds in liquid samples through the design, connection and control of flow paths and structures, and the analysis processes such as automatic sampling, reagent adding, mixing reaction and spectrophotometric detection, so that reagent consumption and waste liquid discharge are reduced, and the analysis detection sensitivity, accuracy and precision are improved.

This invention provides a method for preparing 4,1-disubstituted pyrrolo[1,2-a]quinoxaline-1-yl ketone derivatives, belonging to the field of organic synthesis technology. This invention uses 2-(1H-pyrrolo-1-yl)aniline compounds and α-carbonyl acids as reactants, employing only ammonium persulfate as an oxidant. Under metal-free catalysis, a one-pot tandem reaction is carried out to simultaneously complete the cyclization of the pyrrolo[1,2-a]quinoxaline nucleus and the C-1 acylation modification. The substituents at the 4- and 1-positions of the product can be flexibly controlled by changing the α-carbonyl acid with different structures. This method requires no pre-modified substrate, eliminates the need for metal catalysts, avoids the risk of metal residue, and features simplified steps and high functional group compatibility, providing a new green and low-cost route for the synthesis of polysubstituted pyrrolo[1,2-a]quinoxaline ketone derivatives.

The application belongs to the technical field of aniline compound preparation, and particularly relates to a synthesis method of deuterated aniline based on transition metal catalyzed nitrobenzene compound. The method uses nitrobenzene compound as raw material, is catalyzed by a low-load transition metal catalyst, and adopts one-pot method to complete the series reaction of high-selectivity hydrogenation and hydrogen-deuterium exchange of the nitrobenzene compound, so that the deuterated aniline compound with high added value is obtained. The yield of the deuterated product and the deuterium substitution rate of the product are better than those of conventional hydrogenation and deuterium substitution, the product is stable and cannot be easily replaced by hydrogen to return to the raw material, and the operation and application are convenient.

The present invention relates to the compound of formula (I), and a stereoisomer, a tautomer, a stable isotopic variation, a pharmaceutically acceptable salt or a solvate thereof, a pharmaceutical composition containing the compound, a method for using the compound for treating or preventing an RORγ-related disease, and use of the compound in the preparation of a drug for treating or preventing the RORγ-related disease.

The invention belongs to the field of antiviral compounds, and discloses an application of a benzoylaniline compound in preparation of broad-spectrum antiviral drugs. The benzoylaniline compound has a general formula as shown in a formula I, wherein R1, R2, R3, R4 and R5 are at least one of H, C1-4 alkyl, C1-4 alkoxy, halogen, hydroxyl and nitryl; wherein H on the C1-4 alkyl group and H on the C1-4 alkoxy group are optionally substituted by halogen atoms, and the condition is that at least two of R1, R2, R3, R4 and R5 are halogens, but not more than 4; at least one of R1, R2, R3, R4 and R5 is F, but not more than 2. The compound disclosed by the invention has a relatively good in-vitro antiviral effect, and the compound BAB162 is wide in antiviral spectrum and has a remarkable inhibition effect on various viruses at low concentration. The BAB162 shows an obvious treatment effect in a piglet viral diarrhea infection model and a mouse acute hepatitis virus infection model.

The invention relates to the technical field of organic synthetic chemistry, in particular to a selenylation preparation method of aniline and an indole compound, which comprises the following steps: A1, reacting the indole compound or the aniline compound with potassium selenide and N-chloro-N-fluorobenzenesulfonamide in an organic solvent at the temperature of 0 DEG C to room temperature; and A2, after the reaction is finished, carrying out extraction, concentration and column chromatography purification to obtain the selenium cyanate indole or aniline derivative, wherein the reaction operation comprises the following steps: dissolving the indole or aniline compound and KSeCN in an organic solvent, slowly dropwise adding CFBSA while stirring at the temperature of 0 DEG C, heating to room temperature after dropwise adding, and continuously stirring for reaction. According to the method, the CFBSA reagent is taken as an oxidizing agent, relatively cheap potassium selenide is taken as a selenium cyano group source, selenylation of aniline, indole and part of aromatic rings is realized at room temperature under a mild oxidation condition, and corresponding products are obtained at medium to excellent yield.

The invention relates to a method for preparing an oxamide ultraviolet absorbent, which comprises the following step of: reacting a first aniline compound in a formula I, a second aniline compound in a formula II and an oxalyl compound in a formula III in the presence of a catalyst to obtain the oxamide ultraviolet absorbent in a formula IV. The oxamide ultraviolet absorbent, especially the ultraviolet absorbent 312, is prepared through a one-step method, the process route is simple, generation and treatment of intermediates are avoided, the process route is effectively simplified, the time cost is greatly reduced, and then the energy consumption and the production cost are reduced; the impurity content in the preparation process is low, the product purity is high, and the yield is high; the method is low in operation difficulty, low in equipment requirement, capable of achieving continuous feeding production and suitable for industrial production.

The invention discloses a method for synthesizing quinoxaline derivatives by catalyzing arylamine and a diazo compound through acidic functionalized ionic liquid, and belongs to the technical field of fine organic synthesis. A 2-aryl aniline compound and a diazo compound are placed in the presence of a solvent, an acid and an ionic liquid, subjected to a cascade reaction of wolf rearrangement, nucleophilic addition, oxidation and cyclization at 100-140 DEG C, cooled to the room temperature, extracted with ethyl acetate, dried with anhydrous sodium sulfate and then subjected to reduced pressure distillation to remove the solvent, a mixed crude product is obtained, and the 2-aryl aniline compound is obtained. And separating and purifying the mixture by adopting silica gel column chromatography to obtain the quinoxaline derivative. The method has the advantages that the catalyst is green and renewable, the operation is simple, the selectivity is high, the substrate range is wide, and the tolerance to functional groups is good, the diazo compound is rearranged into the phthalic acid by virtue of tandem wolf rearrangement, nucleophilic addition, oxidation and cyclization, and a new way is provided for synthesis of quinoxaline derivatives.

The application discloses a kind of microcapsules and its preparation method and application, the microcapsule is composed of capsule wall and chamber, the capsule wall is formed by hydrophobic nanoparticle self-assembly, the chamber is filled with analyte;The hydrophobic nanoparticle is prepared by hydrophobic modification of metal nanoparticle using fluorinated organic mercaptan to modify metal nanoparticle or oxidation dianiline compound.The microcapsule of the application has higher hot spot density in all spatial planes, and has strong tolerance to laser focus mispositioning, and is expected to be used to build high-reproducibility SERS sensing platform.The microcapsule constructed in the application can realize the integration of identification enrichment and SERS label-free detection to improve the sensitivity of detection for high-Raman-active molecules;For low-content and small-Raman-scattering-cross-section compounds, microcapsules can also realize the ultra-sensitive detection of target substances by integrating identification enrichment and SERS sensing detection.

The application discloses a method for photocatalytic synthesis of aniline compounds containing heptafluoroisopropyl substitution, which comprises the following steps: mixing o-methylaniline, 2-bromoheptafluoropropane and an iridium photocatalyst, adding an ultradry solvent, stirring and reacting the reaction mixture under a light source, and maintaining the reaction temperature at room temperature to obtain the target product, i.e. the aniline compound containing heptafluoroisopropyl substitution. The application adopts photocatalysis, does not need heating, has no solid waste problem, is more environmentally friendly compared with a traditional sodium hydrosulfite reduction reaction, and has a much higher photocatalytic reaction yield than the traditional reduction reaction, low catalyst consumption, high yield and good selectivity.

This invention provides a method for producing norborneneimide derivatives using a simple manufacturing process and with a high reaction conversion rate. [Solution] A method for producing norborneneimide derivatives, comprising a reaction step of reacting a 5-norbornene-2,3-dicarboxylic acid anhydride represented by the following formula (1) with an aniline compound in the presence of an organic solvent with a boiling point of 120°C or higher. JPEG2026085818000009.jpg48170

The invention belongs to the technical field of preparation of o-alkynyl aniline compounds, and particularly relates to a preparation method of an o-alkynyl aniline compound with an aggregation-induced emission property. The preparation method comprises the following steps: (1) under the catalytic action of bis (triphenylphosphine) palladium dichloride and cuprous iodide, reacting 1, 2-bis (4-bromophenyl)-1, 2-stilbene with trimethylsilylacetylene to obtain an intermediate crude product, and then performing trimethylsilyl removal reaction on the intermediate crude product to obtain 1, 2-bis (4-ethynylphenyl)-1, 2-diphenylethylene; 2, 2-diphenylethylene; and (2) under the catalytic action of bis (triphenylphosphine) palladium dichloride and cuprous iodide, carrying out a reaction on 1, 2-bis (4-ethynylphenyl)-1, 2-diphenylethylene and 2-iodoaniline to prepare the o-alkynyl aniline compound. The o-alkynyl aniline compound prepared by the preparation method disclosed by the invention has a good aggregation-induced emission property.

This invention provides a method for treating nitrochlorobenzene tar by catalytic hydrogenation to obtain aniline compounds containing chloroaniline and chlorodiphenylamine. This invention utilizes low-value production wastewater to produce chloroaniline and chlorodiphenylamine, which have higher economic value, thus solving the problems of high safety risks and low recovery rates in existing nitrochlorobenzene tar disposal methods.

The invention discloses a compound as shown in a formula (I) and a preparation method thereof, and relates to application of the compound in preparation of an orexin receptor antagonist. In the compound shown in the formula (I), X represents chlorine or bromine or iodine; one of R1 and R2 represents hydrogen, and the other one represents an amino protecting group; or R1 and R2 are respectively independent amino protecting groups, or R1 and R2 together form an amino protecting group. The compound shown in the formula (I) is obtained by taking 3-methyl-2-nitrobenzoic acid or 3-methyl-2-nitroaniline as an initial raw material through degradation rearrangement or amino protection, halogenation reaction and reduction reaction. The amino protecting group is creatively introduced, generation of 2-position halogenated impurities in the reaction is greatly reduced, the yield is improved, when the compound is used for synthesizing the orexin receptor antagonist, a single target compound is generated, generation of impurities is effectively avoided, the yield is improved, the cost is reduced, and the compound is suitable for industrial production.

The application discloses an Azos polymer mixed matrix membrane and a preparation method and application thereof, the method is as follows: one or more aniline compounds are dissolved in an organic solvent, and a coupling reaction is carried out under the action of a catalyst and a catalyst auxiliary agent thereof; after the reaction is completed, filtering, washing and drying are sequentially carried out, and Azos particles with an azo functional group are obtained; the Azos particles are ultrasonically dispersed in an organic solvent, and are added into a dissolved polymer matrix solution to blend, and a casting solution is obtained after uniform stirring; the obtained casting solution is treated by ultrasonic defoaming, and then a vacuum assisted film forming method or a high pressure and vacuum coupled film forming method or a solution casting method is adopted to form a film, finally, the film is placed into an oven for drying at 70-90 DEG C for 10-15 h, and an Azos / polymer mixed matrix membrane is obtained. The application has the advantages of simple operation, environmental friendliness, low cost and the like, and provides a new selection for the fields of bio-ethanol preparation, gas adsorption / separation and the like.

The present disclosure provides crystalline forms of the compound having formula (I): (I), wherein the crystalline forms are crystalline Forms A, B, C, E, F, and H, each of which is characterized by an X-ray powder diffraction (XRPD) pattern. The present disclosure also provides methods for preparing crystalline forms, in particular Form A. The present disclosure further provides methods of treating various skin disorders using the crystalline forms of the disclosure or a pharmaceutical composition thereof.

The invention discloses a 5-fluoro-2, 4-dinitro-3-(trifluoromethyl) aniline compound, which is prepared by the following method: reacting 3, 5-difluorotrifluoromethyl benzene at the high temperature of 160 DEG C by using fuming sulphuric acid and sodium nitrate as nitrating agents for 6 hours, cooling, separating out by using ice water after the temperature is reduced to room temperature, filtering, washing and drying to obtain 1, 5-difluoro-2, 4-dinitro-3-(trifluoromethyl) aniline, and separating out 1, 5-difluoro-2, 4-dinitro-3-(trifluoromethyl) aniline from the 1, 5-difluoro-2, 4-dinitro-3-(trifluoromethyl) aniline to obtain 1, 5-difluoro-2, 4-dinitro-3-(trifluoromethyl) aniline. The catalyst is 2, 4-dinitro-3-(trifluoromethyl) benzene. The preparation method comprises the following steps: dissolving 1, 5-difluoro-2, 4-dinitro-3-(trifluoromethyl) benzene in tetrahydrofuran, slowly dropwise adding an ammonia water solution, and naturally volatilizing to obtain the 5-fluoro-2, 4-dinitro-3-(trifluoromethyl) aniline (PFDNTN). The 5-fluoro-2, 4-dinitro-3-(trifluoromethyl) aniline prepared by the invention has a proper melting point (100 DEG C), and is relatively high in decomposition rate (322 DEG C), and the impact sensitivity is not lower than 40J; and the friction sensitivity is not lower than 360 N. The detonation velocity is 7066 m s <-1 >, and the detonation pressure is 24.65 Gpa, which is superior to that of TNT. And the explosive is expected to become a casting carrier explosive for replacing TNT.

The application discloses a preparation method of a phenylacetyl acetic acid compound, relates to the technical field of chemical synthesis, and the synthesis route of the phenylacetyl acetyl acid compound is as follows: an aniline compound connected with five groups of R1, R2, R3, R4 and R5 is used as a raw material, a diazotization reagent is added under acidic conditions to perform a diazotization reaction, a phase transfer catalyst, a copper catalyst and divinyl ketone are added to perform a reaction, and hydrolysis is performed under acidic conditions to obtain the phenylacetyl acetic acid compound; wherein R1, R2, R3, R4 and R5 are each independently selected from F, Cl, Br, -CH3, -OCH3, NO2, -C2H5, -C3H7, -CF3 or H, and are not H at the same time; when one or more of R1, R2, R3, R4 and R5 is F, the rest are not all H; and X is selected from Cl or Br. The raw material prepared by the application is easy to obtain, the operation is simple, the reaction condition is mild, the danger is low, the reaction step is short, the production cost and three waste emissions of enterprises are reduced, and large-scale industrial production can be easily realized.

The application discloses a kind of biochar loaded iron monatomic catalyst and application thereof, adopt morel fungus filament as biochar pyrolysis precursor, surface complex iron ion, obtain biochar loaded iron monatomic catalyst in inert gas atmosphere high temperature pyrolysis.4-hydroxy-2-butanone and different aniline compounds are used as reaction substrate, using biochar loaded iron monatomic catalyst, acetone or butanone is solvent, in nitrogen atmosphere, N-alkylation product is obtained at room temperature reaction.This application first uses morel fungus as the pyrolysis precursor of carbon carrier and prepares monatomic catalyst.The biochar monatomic catalyst prepared in the application has similar morphology of carbon nanotube.The application first uses iron monatomic catalyst to catalyze aniline and 4-hydroxy-2-butanone alcohol amine reaction.

The present invention is a lubricant composition that comprises at least three components. The first component is particular oxygenated polymer as described herein. The second required component is at least one American Petroleum Institute (API) base oil. The third required component is an additive comprising a nitrogen-containing compound, wherein the nitrogen-containing compound comprises at least one compound selected from the group consisting off phenylamine compounds (preferably with a carbamate), phosphate amine compounds, and triazole compounds.

The application belongs to the technical field of preparation of o-alkynyl aniline compounds, and particularly relates to a preparation method of an o-alkynyl aniline compound with an aggregation-induced emission property. The preparation method comprises the following steps: (1) under the catalysis of bis-triphenylphosphine palladium dichloride and cuprous iodide, 1,2-bis(4-bromophenyl)-1,2-stilbene is reacted with trimethylsilyl acetylene to prepare an intermediate crude product, and then the intermediate crude product is subjected to a trimethylsilyl group removal reaction to prepare 1,2-bis(4-ethynylphenyl)-1,2-diphenyl ethylene; (2) under the catalysis of bis-triphenylphosphine palladium dichloride and cuprous iodide, 1,2-bis(4-ethynylphenyl)-1,2-diphenyl ethylene is reacted with 2-iodoaniline to prepare an o-alkynyl aniline compound. The o-alkynyl aniline compound prepared by the application has a good aggregation-induced emission property.

The invention discloses a sulfonation method of an alkylaniline compound, and belongs to the technical field of organic synthesis. According to the method, sulfur trioxide is used as a sulfonating agent, 1, 2-dichloroethane, dichloromethane or trichloromethane is selected as a solvent, and efficient sulfonation of the alkylaniline compound is realized by controlling key parameters such as reaction temperature, sulfur trioxide introduction speed, heat preservation time and the like. The technical problem that a large amount of dilute sulphuric acid wastewater and sodium sulfate solid waste are generated in a traditional fuming sulphuric acid sulfonation process is solved, the solvent can be recycled infinitely, the HPLC purity of the product is larger than or equal to 99.4%, the yield is larger than or equal to 94%, and the method has the remarkable advantages of being environmentally friendly, efficient and low in cost and is suitable for industrial large-scale production.

The invention discloses a preparation method and application of an imine covalent organic framework material containing DBU-based ionic liquid. An aniline compound and a phthalaldehyde compound are used as raw materials for condensation reaction to obtain an imine bond covalent organic framework, and then DBU-based ionic liquid is connected to the covalent organic framework through a covalent bond to prepare the material. The material obtained by the invention has the advantages of uniformly distributed active sites, better stability, easiness in recovery and the like, and can show excellent catalytic performance when being applied to two different reactions of catalyzing cycloaddition of carbon dioxide and epoxypropane to synthesize propylene carbonate and catalyzing ester exchange of propylene carbonate and methanol to synthesize dimethyl carbonate.