80 results about "Aniline Compounds" patented technology

Provided herein are topical formulations including a compound of formula (I) and methods of using these topical formulations for the treatment of skin diseases, wherein the topical formulations include non-aqueous gel, aqueous gel, and emulsion-based formulations; and the compound of formula (I) is represented bywherein R1, R2, R2a, R3, R3a, and R3b are as defined and described herein.

The invention discloses an Azos polymer mixed matrix membrane and a preparation method and application thereof, and the method comprises the following steps: dissolving one or more aniline compounds in an organic solvent, and carrying out a coupling reaction under the action of a catalyst and a catalyst auxiliary agent; after the reaction is finished, filtering, washing and drying in sequence to obtain Azos particles with azo functional groups; ultrasonically dispersing Azos particles in an organic solvent, adding the Azos particles into the dissolved polymer matrix solution, blending, and uniformly stirring to obtain a membrane casting solution; and carrying out ultrasonic defoaming treatment on the obtained membrane casting solution, preparing a membrane by adopting a vacuum-assisted membrane forming method or a high-pressure and vacuum coupling membrane forming method or a solution pouring method, and finally drying the membrane in a drying oven at 70-90 DEG C for 10-15 hours to obtain the Azos / polymer mixed matrix membrane. The method has the advantages of being easy to operate, environmentally friendly, low in cost and the like, and a new choice is provided for the fields of bioethanol preparation, gas adsorption / separation and the like.

The present disclosure provides crystalline forms of the compound having formula (I): (I), wherein the crystalline forms are crystalline Forms A, B, C, E, F, and H, each of which is characterized by an X-ray powder diffraction (XRPD) pattern. The present disclosure also provides methods for preparing crystalline forms, in particular Form A. The present disclosure further provides methods of treating various skin disorders using the crystalline forms of the disclosure or a pharmaceutical composition thereof.

The invention discloses a method for preparing a bio-based disazo lake pigment, comprising the following steps: S1, aniline compound is diazotized with sodium nitrite under the action of acid solution, and then coupled with 2,5-hydroxyterephthalic acid to prepare disazo-2,5-hydroxyterephthalic acid dye; S2, the disazo-2,5-hydroxyterephthalic acid dye prepared in step S1 is reacted with a metal salt in an aqueous solution to prepare a bio-based disazo lake pigment. In the present invention, the main raw material of the bio-based disazo lake pigment comes from biological fermentation, the preparation method is simple, and the structure has two pairs of adjacent hydroxyl groups and carboxyl groups, which can have a good complexing effect on metal ions, and is easy to form an intermolecular association to stabilize the metal ions. The organic lake pigment prepared by the present invention can tolerate a wide pH range without the freeing of metal ions when used to prepare an aqueous color paste, and does not affect the viscosity and tinting power of the color paste.

This invention provides a benzene-azo group-grafted polyhydroxy graphene oxide-based material and its application in electromagnetic wave absorption. The material is synthesized using aniline compounds and polyhydroxy graphene oxide as raw materials via diazo coupling. The feasibility of the preparation method was verified by spectral characterization, demonstrating the feasibility of impedance matching through covalent grafting of functionalized functional groups. This preparation method is simple, low-cost, and yields high output.

The invention discloses a method for preparing nitrone compounds by using a non-heme double-iron-ion enzyme, and belongs to the field of biological enzyme catalysis. A substituted styrene compound and a substituted aniline compound are used as substrates and react in a PBS buffer solution in the presence of non-heme double iron ion type amino oxidase AzoC to obtain the nitrone compound. According to the present invention, the enzyme catalysis nitrone synthesis system verifies the feasibility of the non-heme double iron ion type amino oxidase mediated bimolecular nitrone compound synthesis, the solid foundation is laid for the subsequent research and application, and the strategy provides the basis for the subsequent enzyme modification and optimization.

The present invention relates to a novel haloalkyl sulfonanilide compound or a salt thereof, a herbicide composition containing the compound or salt thereof, a method of weed control, including the step of applying the herbicide composition, and a method of producing the compound.

The invention discloses a process for catalytically synthesizing a triazine ultraviolet light absorber based on a nano molecular sieve, which comprises the following steps: preparing raw materials, preparing zeolite and a molecular sieve Y to prepare a nano molecular sieve catalyst, and synthesizing and activating the nano molecular sieve catalyst to obtain the triazine ultraviolet light absorber. The method comprises the following steps: synthesizing a nano molecular sieve catalyst by a sol-gel method, activating the catalyst by removing a template substance through high-temperature calcination, synthesizing the catalyst, adding an aniline compound and an amino compound into a reactor, adding alcohols, ketones and a non-polar solvent at the same time, and reacting at the pressure of 200 DEG C; the nano molecular sieve catalyst is used in the synthesis process, the catalyst is synthesized by a sol-gel method, and is obtained by removing a template substance through high-temperature calcination, and the high specific surface area and the unique pore structure of the nano molecular sieve can provide a larger reaction surface and enhance the contact of reactants.

The invention discloses a multi-mode liquid chromatography filler of ionic liquid hydrogel modified silica gel and preparation and application thereof, and the method comprises the following steps: fully dissolving an ionic liquid hydrogel monomer and a cross-linking agent in a polar aprotic organic solvent, adding silica gel, carrying out ultrasonic treatment, and standing; adding an initiator, stirring, condensing, refluxing, stirring and reacting at 70-80 DEG C in an inert atmosphere; and drying under stirring, centrifugally washing and drying. According to the invention, the problems of single functional group, tedious modification steps, low ligand density and poor high-pressure stability in the existing method are solved. The preparation method is simple and convenient, efficient modification of hydrogel on the surface of silica gel can be achieved, and the prepared liquid chromatography packing has good separation selectivity on nucleoside / basic groups, organic acid compounds, alkaloid, antibiotics, aniline compounds, anion-containing compounds and the like; and chromatographic separation in a hydrophilic chromatographic mode, a hydrophobic chromatographic mode and an ion exchange chromatographic mode can be realized.

The present application provides a phenylacetaldehyde derivative as shown in formula (1), and also provides a preparation method of the phenylacetaldehyde derivative and the use of the phenylacetaldehyde derivative as a color developing agent for detecting aniline compounds. The present application also provides a method for detecting the content of aniline compounds and a method for monitoring the discharge of waste brine in an isocyanate production process. The phenylacetaldehyde derivative provided by the present application has strong color developing ability, and can quickly react and show obvious changes in color even at very low content of aniline compounds. The detection method provided by the present application is simple to operate, does not require expensive detection instruments, has accurate and reliable detection results, has low detection limit, and can also realize online detection and analysis. The monitoring method provided by the present application can collect data at different discharge sites in real time and judge the process operation condition in time, so that the abnormal working condition can be handled in time, the occurrence of downstream accidents can be avoided, the production safety is improved, and the environmental protection is also facilitated.

The application discloses an automatic analyzer for detecting aniline compounds in liquid and a determination method, and realizes automatic and rapid determination of aniline compounds in liquid samples through the design, connection and control of flow paths and structures, and the analysis processes such as automatic sampling, reagent adding, mixing reaction and spectrophotometric detection, so that reagent consumption and waste liquid discharge are reduced, and the analysis detection sensitivity, accuracy and precision are improved.

This invention provides a method for preparing 4,1-disubstituted pyrrolo[1,2-a]quinoxaline-1-yl ketone derivatives, belonging to the field of organic synthesis technology. This invention uses 2-(1H-pyrrolo-1-yl)aniline compounds and α-carbonyl acids as reactants, employing only ammonium persulfate as an oxidant. Under metal-free catalysis, a one-pot tandem reaction is carried out to simultaneously complete the cyclization of the pyrrolo[1,2-a]quinoxaline nucleus and the C-1 acylation modification. The substituents at the 4- and 1-positions of the product can be flexibly controlled by changing the α-carbonyl acid with different structures. This method requires no pre-modified substrate, eliminates the need for metal catalysts, avoids the risk of metal residue, and features simplified steps and high functional group compatibility, providing a new green and low-cost route for the synthesis of polysubstituted pyrrolo[1,2-a]quinoxaline ketone derivatives.

The present invention relates to a lubricant composition, in particular for a gas or steam turbine, comprising: —at least one base oil; —at least one phenylnaphthylamine (PAN) compound, preferably alkylphenyl-α-naphthylamine (APAN) compound; —at least one diphenylamine (DPA) compound, preferably dialkyl-diphenylamine compound; and —at least one phosphite ester compound, preferably triaryl phosphite ester compound; in which the ratio by weight between said diphenylamine compound(s) and said phosphite ester compound(s) is strictly greater than 1.0.

The application belongs to the technical field of aniline compound preparation, and particularly relates to a synthesis method of deuterated aniline based on transition metal catalyzed nitrobenzene compound. The method uses nitrobenzene compound as raw material, is catalyzed by a low-load transition metal catalyst, and adopts one-pot method to complete the series reaction of high-selectivity hydrogenation and hydrogen-deuterium exchange of the nitrobenzene compound, so that the deuterated aniline compound with high added value is obtained. The yield of the deuterated product and the deuterium substitution rate of the product are better than those of conventional hydrogenation and deuterium substitution, the product is stable and cannot be easily replaced by hydrogen to return to the raw material, and the operation and application are convenient.

The present invention relates to the compound of formula (I), and a stereoisomer, a tautomer, a stable isotopic variation, a pharmaceutically acceptable salt or a solvate thereof, a pharmaceutical composition containing the compound, a method for using the compound for treating or preventing an RORγ-related disease, and use of the compound in the preparation of a drug for treating or preventing the RORγ-related disease.

The invention belongs to the field of antiviral compounds, and discloses an application of a benzoylaniline compound in preparation of broad-spectrum antiviral drugs. The benzoylaniline compound has a general formula as shown in a formula I, wherein R1, R2, R3, R4 and R5 are at least one of H, C1-4 alkyl, C1-4 alkoxy, halogen, hydroxyl and nitryl; wherein H on the C1-4 alkyl group and H on the C1-4 alkoxy group are optionally substituted by halogen atoms, and the condition is that at least two of R1, R2, R3, R4 and R5 are halogens, but not more than 4; at least one of R1, R2, R3, R4 and R5 is F, but not more than 2. The compound disclosed by the invention has a relatively good in-vitro antiviral effect, and the compound BAB162 is wide in antiviral spectrum and has a remarkable inhibition effect on various viruses at low concentration. The BAB162 shows an obvious treatment effect in a piglet viral diarrhea infection model and a mouse acute hepatitis virus infection model.

The invention provides a nitro hydrogenation catalyst, a preparation method thereof and a catalytic hydrogenation preparation method of aniline compounds. The preparation method comprises the following steps: preparing a zirconium source solution from a zirconium source, a first acid agent and water, and adding a first precipitator into the zirconium source solution to obtain a mixed solution A; preparing a cerium source, a second acid agent and water into a mixed solution B, and adding the mixed solution B and a second precipitator into the mixed solution A to obtain a mixed solution C; carrying out hydrothermal reaction on the mixed solution C to obtain a carrier precursor; calcining the carrier precursor to obtain a composite carrier; preparing the composite carrier and water into first slurry, adding a nickel source into the first slurry, and mixing to obtain second slurry; and adding a boron source and a phosphorus source into the second slurry, and stirring for reaction to obtain the nitro hydrogenation catalyst. The preparation method comprises the following steps: preparing the composite zirconium-cerium carrier, reducing the nickel source through the boron source and the phosphorus source, and depositing on the obtained composite zirconium-cerium carrier to obtain the nitro hydrogenation catalyst with excellent performance.

The invention relates to the field of high-performance resin-based materials, in particular to a high-solid-content low-viscosity polyamide acid salt solution and a preparation method thereof. The method comprises the following steps: (1) carrying out polymerization reaction on a dianhydride monomer and a diamine monomer to obtain a polyamide acid solution; (2) the polyamic acid solution and organic alkali are subjected to a contact reaction, a polyamic acid salt original solution is obtained, and the organic alkali is selected from one or more of pyridine compounds and aniline compounds; (3) carrying out precipitation treatment on the polyamic acid salt raw solution to obtain polyamic acid salt powder; and (4) dissolving the polyamic acid salt powder to obtain a polyamic acid salt solution. According to the method disclosed by the invention, the polyamide acid salt solution with high solid content can be prepared, and the polyamide acid salt solution has relatively low apparent viscosity under the condition of high solid content, so that the polyamide acid salt solution has excellent processability and a wide application range.

The invention relates to the technical field of organic synthetic chemistry, in particular to a selenylation preparation method of aniline and an indole compound, which comprises the following steps: A1, reacting the indole compound or the aniline compound with potassium selenide and N-chloro-N-fluorobenzenesulfonamide in an organic solvent at the temperature of 0 DEG C to room temperature; and A2, after the reaction is finished, carrying out extraction, concentration and column chromatography purification to obtain the selenium cyanate indole or aniline derivative, wherein the reaction operation comprises the following steps: dissolving the indole or aniline compound and KSeCN in an organic solvent, slowly dropwise adding CFBSA while stirring at the temperature of 0 DEG C, heating to room temperature after dropwise adding, and continuously stirring for reaction. According to the method, the CFBSA reagent is taken as an oxidizing agent, relatively cheap potassium selenide is taken as a selenium cyano group source, selenylation of aniline, indole and part of aromatic rings is realized at room temperature under a mild oxidation condition, and corresponding products are obtained at medium to excellent yield.

The invention relates to a method for preparing an oxamide ultraviolet absorbent, which comprises the following step of: reacting a first aniline compound in a formula I, a second aniline compound in a formula II and an oxalyl compound in a formula III in the presence of a catalyst to obtain the oxamide ultraviolet absorbent in a formula IV. The oxamide ultraviolet absorbent, especially the ultraviolet absorbent 312, is prepared through a one-step method, the process route is simple, generation and treatment of intermediates are avoided, the process route is effectively simplified, the time cost is greatly reduced, and then the energy consumption and the production cost are reduced; the impurity content in the preparation process is low, the product purity is high, and the yield is high; the method is low in operation difficulty, low in equipment requirement, capable of achieving continuous feeding production and suitable for industrial production.

The invention discloses a method for synthesizing quinoxaline derivatives by catalyzing arylamine and a diazo compound through acidic functionalized ionic liquid, and belongs to the technical field of fine organic synthesis. A 2-aryl aniline compound and a diazo compound are placed in the presence of a solvent, an acid and an ionic liquid, subjected to a cascade reaction of wolf rearrangement, nucleophilic addition, oxidation and cyclization at 100-140 DEG C, cooled to the room temperature, extracted with ethyl acetate, dried with anhydrous sodium sulfate and then subjected to reduced pressure distillation to remove the solvent, a mixed crude product is obtained, and the 2-aryl aniline compound is obtained. And separating and purifying the mixture by adopting silica gel column chromatography to obtain the quinoxaline derivative. The method has the advantages that the catalyst is green and renewable, the operation is simple, the selectivity is high, the substrate range is wide, and the tolerance to functional groups is good, the diazo compound is rearranged into the phthalic acid by virtue of tandem wolf rearrangement, nucleophilic addition, oxidation and cyclization, and a new way is provided for synthesis of quinoxaline derivatives.

The application discloses a kind of microcapsules and its preparation method and application, the microcapsule is composed of capsule wall and chamber, the capsule wall is formed by hydrophobic nanoparticle self-assembly, the chamber is filled with analyte;The hydrophobic nanoparticle is prepared by hydrophobic modification of metal nanoparticle using fluorinated organic mercaptan to modify metal nanoparticle or oxidation dianiline compound.The microcapsule of the application has higher hot spot density in all spatial planes, and has strong tolerance to laser focus mispositioning, and is expected to be used to build high-reproducibility SERS sensing platform.The microcapsule constructed in the application can realize the integration of identification enrichment and SERS label-free detection to improve the sensitivity of detection for high-Raman-active molecules;For low-content and small-Raman-scattering-cross-section compounds, microcapsules can also realize the ultra-sensitive detection of target substances by integrating identification enrichment and SERS sensing detection.

The application discloses a method for photocatalytic synthesis of aniline compounds containing heptafluoroisopropyl substitution, which comprises the following steps: mixing o-methylaniline, 2-bromoheptafluoropropane and an iridium photocatalyst, adding an ultradry solvent, stirring and reacting the reaction mixture under a light source, and maintaining the reaction temperature at room temperature to obtain the target product, i.e. the aniline compound containing heptafluoroisopropyl substitution. The application adopts photocatalysis, does not need heating, has no solid waste problem, is more environmentally friendly compared with a traditional sodium hydrosulfite reduction reaction, and has a much higher photocatalytic reaction yield than the traditional reduction reaction, low catalyst consumption, high yield and good selectivity.

This invention provides a method for producing norborneneimide derivatives using a simple manufacturing process and with a high reaction conversion rate. [Solution] A method for producing norborneneimide derivatives, comprising a reaction step of reacting a 5-norbornene-2,3-dicarboxylic acid anhydride represented by the following formula (1) with an aniline compound in the presence of an organic solvent with a boiling point of 120°C or higher. JPEG2026085818000009.jpg48170

To provide a new method for producing a methylenedianiline compound without the need for formaldehyde.SOLUTION: There is provided a method for producing a methylenedianiline compound, characterized by heating an aniline compound to 25-100°C under a carbon dioxide partial pressure of 0.005-10 MPa (absolute pressure) in the presence of a reducing agent and a catalyst, and then adding an acid and heating to 25-100°C.SELECTED DRAWING: None

The invention belongs to the technical field of preparation of o-alkynyl aniline compounds, and particularly relates to a preparation method of an o-alkynyl aniline compound with an aggregation-induced emission property. The preparation method comprises the following steps: (1) under the catalytic action of bis (triphenylphosphine) palladium dichloride and cuprous iodide, reacting 1, 2-bis (4-bromophenyl)-1, 2-stilbene with trimethylsilylacetylene to obtain an intermediate crude product, and then performing trimethylsilyl removal reaction on the intermediate crude product to obtain 1, 2-bis (4-ethynylphenyl)-1, 2-diphenylethylene; 2, 2-diphenylethylene; and (2) under the catalytic action of bis (triphenylphosphine) palladium dichloride and cuprous iodide, carrying out a reaction on 1, 2-bis (4-ethynylphenyl)-1, 2-diphenylethylene and 2-iodoaniline to prepare the o-alkynyl aniline compound. The o-alkynyl aniline compound prepared by the preparation method disclosed by the invention has a good aggregation-induced emission property.

The present invention provides a nitro hydrogenation catalyst, a preparation method thereof, and a catalytic hydrogenation preparation method for aniline compounds. The preparation method comprises: preparing a zirconium source, a first acid agent, and water to form a zirconium source solution, and adding a first precipitant to the zirconium source solution to obtain a mixed solution A; preparing a cerium source, a second acid agent, and water to form a mixed solution B, and adding the mixed solution B and the second precipitant to the mixed solution A to obtain a mixed solution C; subjecting the mixed solution C to a hydrothermal reaction to obtain a carrier precursor; calcining the carrier precursor to obtain a composite carrier; preparing the composite carrier and water to form a first slurry, and adding a nickel source to the first slurry to obtain a second slurry after mixing; and adding a boron source and a phosphorus source to the second slurry and stirring the reaction to obtain a nitro hydrogenation catalyst. The present invention first prepares a composite zirconium-cerium carrier, then reduces the nickel source with a boron source and a phosphorus source, and deposits the nickel source on the resulting composite zirconium-cerium carrier, thereby obtaining a nitro hydrogenation catalyst with superior performance.

This invention provides a method for treating nitrochlorobenzene tar by catalytic hydrogenation to obtain aniline compounds containing chloroaniline and chlorodiphenylamine. This invention utilizes low-value production wastewater to produce chloroaniline and chlorodiphenylamine, which have higher economic value, thus solving the problems of high safety risks and low recovery rates in existing nitrochlorobenzene tar disposal methods.

The invention relates to a method for synthesizing a trifluoromethylaniline derivative by catalyzing direct trifluoromethylation of aniline compounds with visible light. According to the method, a tetradentate platinum (II) complex Pt (1-ptz) is used as a photocatalyst, a Umemoto reagent or a Langlois reagent (CF3SO2Na) is used as a trifluoromethyl source, direct trifluoromethylation of an aniline compound is realized under irradiation of visible light, the reaction does not need to use a redox reagent and does not need to protect an exposed amino group, and meanwhile, recovery and reuse of the photocatalyst are realized.