221 results about "Aniline Compounds" patented technology

This invention provides substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and/or disorder or a bone-related disease and/or disorder.

The invention relates to novel pyrazolyl carboxanilides of formula (I), in which R, R1, R2 and R3 are defined as per the description, to several methods for producing said substances and to the use thereof for combating undesired micro-organisms. The invention also relates to novel intermediate products and to the production of the same.

Novel thiazole aniline compounds, pharmaceutical compositions, methods of making them and uses thereof in treating M₃ muscarinic acetylcholine receptor mediated diseases are disclosed.

Novel addition products of hydroxyl-protecting groups (such as isocyanates) with oxyalkylene-substituted intermediates, such as poly(oxyalkylenated) aniline compounds, for the eventual production of substituted, and substantially pure, colorants, particularly diazo and triphenylmethane derivatives, through the reaction of such intermediates with certain reactants are provided. These new colorants exhibit improved wax and/or oil solubility and high purity, particularly due to the inability of certain impurities to deleteriously react with the protected hydroxyl groups of either the intermediate or the colorant during and/or after formation thereof. A method for producing such novel colorants through utilization of these novel substantially pure colorant intermediates is also provided.

Novel addition products of hydroxyl-protecting groups (such as isocyanates) with oxyalkylene-substituted intermediates, such as poly(oxyalkylenated) aniline compounds, for the eventual production of substituted, and substantially pure, colorants, particularly diazo and triphenylmethane derivatives, through the reaction of such intermediates with certain reactants are provided. These new colorants exhibit improved wax and/or oil solubility and high purity, particularly due to the inability of certain impurities to deleteriously react with the protected hydroxyl groups of either the intermediate or the colorant during and/or after formation thereof. A method for producing such novel colorants through utilization of these novel substantially pure colorant intermediates is also provided.

Motilide compounds having the formula (I),

wherein R¹, R², R³, and R⁴ are as defined herein, and methods for their preparation and use in the treatment of diseases or conditions characterized by impaired gastric motility.

The present invention provides a lubricating oil composition comprising a lube base oil comprising a mineral oil and/or a synthetic oil; (A) an alkenylsuccinimide or an alkylsuccinimide and/or a boron-containing derivative thereof in an amount of 0.01 to 0.14% by mass based on the composition in terms of the nitrogen content as an ashless dispersant, wherein an alkenylsuccic acid monoimide or an alkylsuccinic acid monoimide and/or a boron-containing derivative thereof in the ashless dispersant is 0.05% by mass or less in terms of nitrogen content; and (B) a dialkyldiphenylamine compound in an amount of 0.3 to 5.0% by mass and a hindered phenol compound in an amount of 0 to 2.5% by mass based on the composition as an antioxidant, and (C) a sulfated ash of the lubricating oil composition is 1.2% by mass or less. The lubricating oil composition suitable for internal combustion engines has excellent oxidation stability despite low ash content, exhibits small increase in viscosity and acid number, and can prolong the interval (distance or time) required for changing lubricating oil.

The invention relates to a catalytic hydrogenation synthesis method to prepare aniline compounds, and specifically relates to a method utilizing catalytic hydrogenation synthesis of nitrobenzene compounds to prepare aniline compounds. Raney Ni is taken as the catalyst, hydrogen gas is taken as the hydrogen source, and then metal salts are added into a liquid phase system to make nitrobenzene compounds carry out catalytic hydrogenation reactions to generate the aniline compounds. The addition amount of the metal salts is 1 to 10 mol% of the amount of substance of the reaction substrate. The provided method has the advantages of mild conditions, high reaction efficiency, simple operation, easy control, and low investment cost.

The invention relates to a simple and convenient preparation method of a key intermediate (2-methyl-4-amino-5-amino methyl pyrimidine) for the vitamin B1. According to the method, lewis acid is used for catalyzing addition condensation reaction of acetamidine and 3-formyl amino ethyl cyanide and then catalyzing reaction of the condensation product and triethyl orthoformate to introduce a formyl chiral auxiliary, an imdo group and the formyl chiral auxiliary are subjected to ring formation to form 2- methyl-4-formyl amino-5- amino methyl pyrimidine, and finally basic hydrolysis is performed, so that 2-methyl-4-amino-5-amino methyl pyrimidine is obtained. The reaction procedures are carried out sequentially by adopting the one-pot method, the products in each step require no separation and purification, and the operation is simple and convenient. According to the method, highly toxic o-chloroaniline and other phenylamine compounds are not used, so that residue of o-chloroaniline compounds in the vitamin B1 product can be completely avoided. Meanwhile, the production wastewater is less and the yield is high.

The invention relates to a biological agent for treatment of industrial polluted water. The biological agent comprises a composite microbial agent and a carrier, wherein the composite microbial agent is prepared from pseudomonas putida, candida utilis, bacillus amyloliquefaciens, clostridium papyrosolvens, nitrosomonas europaea, paracoccus denitrificans, nitrobacter sp. and paracoccus pantotrophus. The strains are reasonably matched, symbiotic and harmonious and is not mutually antagonistic, the biological agent has a good degradation effect on aniline compounds difficult to degrade after being fed into a wastewater treatment system and is suitable for treatment of the industrial polluted water, the water treatment capacity is increased, the quality of treated water is improved, operation expenses are reduced, and up-to-standard emission is realized.

The invention provides a method for performing gold-catalyzed selective C-H bond functionalization on phenol and aniline, which comprises the following steps: by taking phenol and aniline compounds as raw materials and taking phosphine ligand or carbene as ligand, in organic solvent, reacting with a diazo compound in the presence of a gold catalyst and a silver salt, performing carbon-hydrogen bond insertion at the para-position or ortho-position of the phenol or aniline structure. The method provided by the invention has the characteristics of low catalyst consumption, mild conditions, wide substrate application range and the like; the method can be used for quickly and efficiently synthesizing methyl acetate derivatives containing the phenol or aniline structure; and meanwhile, the method can be used for performing later modification on natural products or drug molecules (such as estrone), or be used for synthesizing some molecules having biological activity, thus having favorable application prospects.

The invention provides novel β₂ adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β₂ adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

The invention discloses a sulfonated aromatic diamine compound as well as a preparation method and application thereof. The sulfonated aromatic diamine compound is as shown in the formula I in the specification. The preparation method of the sulfonated aromatic diamine compound as shown in the formula I comprises the following steps: (1) in the presence of acid, reacting a phenylamine compound as shown in a formula II with a benzaldehyde compound as shown in a formula III in water, after the reaction is accomplished, neutralizing the reaction system by using alkali, and recrystallizing to obtain an aromatic diamine compound as shown in a formula IV; (2) under an ice-bath condition, adding the aromatic diamine compound as shown in the formula IV into concentrated sulfuric acid, and subsequently adding fuming sulfuric acid for reaction so as to obtain the sulfonated aromatic diamine compound as shown in the formula I. As a key initiating agent or functional monomer of a novel efficient demulsifying agent or water clarifier, the sulfonated aromatic diamine compound disclosed by the invention has important values in treating polymer flooding produced liquids.

The invention discloses an organic electroluminescent device which can give out light, comprising an organic electroluminescent device or a substrate, an anode layer and a cathode layer, and an electrode on the surface of the substrate, an organic functional layer between the anode layer and the cathode layer that comprises at least a luminescent layer which is an organic material layer giving out white light driven by an additional power, and is characterized in that the organic material layer giving out white light is made up by a plurality of blue organically functional materials with hole-transporting ability, the blue organically functional material can be one or more materials of aromatic diamines compounds, star-shaped triphenyl-amine compounds, carbazole polymer and metal complexes, DPVBi, BCzVB, Perylene and BczVBi.

Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer.

The invention relates to a portable synthesis method for preparing 2-methyl-4-amino-5-aminoethylpyrimidine through one-step cyclization reaction. The method comprises the following steps: directly catalyzing acetamidine hydrochloride and 3-acyl aminopropionitrile to condense and to react with triester orthoformate for dealcoholization and cyclization by using lewis acid, and then hydrolyzing to obtain a vitamin B1 key intermediate, namely the 2-methyl-4-amino-5-aminoethylpyrimidine. According to the method disclosed by the invention, the raw materials are low in cost and easily obtained, and no sodium alcoholate needs to be used for dissociating acetamidine hydrochloride, thus the decomposition of acetamidine is reduced, and the high yield is achieved through reaction; the cyclization and hydrolysis reactions are sequentially carried out, products in all steps are not required to be separated and purified, and the synthesis method is simple and convenient to operate. Highly carcinogenic o-chloroaniline or other micromolecular aniline compounds are not used, and the portable synthesis method is environment-friendly in process, free of production of wastewater and beneficial to industrial production.

The invention discloses a process for preparing aniline compounds through hydrogenation of nitrobenzene compounds in a multistage fluidized bed. The used catalyst has a double screening characteristic (respectively taking 60-80 microns and 200-300 microns as peak centers), size grading is performed under the gas velocity action, a coarse particle catalyst stacked bed is formed on the lower section of the multistage fluidized bed, and a fine particle catalyst bed is formed on the upper section of the multistage fluidized bed. Moreover, due to the arrangement of an overflow pipe, each catalyst bed section is kept highly stable. Due to an independent heat exchange system, the temperature of each section is kept controllable. The initial fast reaction and strong head transfer function can be realized, and the aim of later advanced gas conversion is achieved. The process disclosed by the invention has the advantages of simplicity in control, high operating flexibility, wide adaptive gas velocity range, high raw material conversion rate (more than 99.990%), high product selectivity (more than 99.40%) and the like.

The invention provides a method for removing aniline substances from organic pigment wastewater. The method comprises the steps that firstly, complexing extraction is conducted on the organic pigment wastewater through a complexing extraction agent in an acidic environment, and after standing is conducted for layering, an extraction phase and an aqueous phase are obtained; secondly, an alkaline solution is added into the extraction phase for complexing extraction agent regeneration, standing is conducted for layering after a mixed reaction is conducted, and then a concentrated solution containing aniline compounds and a regenerated complexing extraction agent are obtained. The method is simple in technology, high in aniline removing rate, low in treatment cost and beneficial for energy conservation, environment protection and reclamation production.