High strength biological cement composition and using the same

a biological cement and composition technology, applied in cement production, medical science, dentistry, etc., can solve the problems of unsuitable for many dental applications, negative effect of set cement quality, and present certain biocompatibility and toxicities, and achieve high mechanical strength, high bioactivity, and high biocompatibility

Active Publication Date: 2007-05-03
INNOVATIVE BIOCERAMIX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0026] The present invention provides a new composition of hydraulic cement, and methods for making and using the composition for biomedical and dental applications. The new hydraulic cement has high mechanical strength, high bioactivity, and high bi

Problems solved by technology

The calcium hydroxide component, which is formed as a result of the setting reaction, negatively effects the quality of the set cement, since CH is soluble in water and has low strength.
However, the MTA composition derived from Portland cement is gray in color, which is unsuitable for many dental applications.
Moreover, among other problems, MTA contains significant amounts of aluminum and consequently presents certain biocompatibility and toxicity concerns, as will be discussed below.
However, this process only decreases the iron content and does not improve the biological properties of the material, since it still contains aluminum.
The material is designated for treatment of hazardous wastes, such as nuclear waste, to prevent leaching, and also for construction materials and structural materials, which would include relatively high levels of impurities and consequently exhibit toxicity unsuitable for medical/dental use.
The presence of aluminum is a major disadvantage of the materials derived from Portland cement (such as MTA or WMTA) when used for biomedical and dental applications.
Research indicates that aluminum ions are toxic to the human biological system.
For example, aluminum inhibits mineralization of bone, and is toxic to osteoblasts.
Aluminum also has adverse effect on red blood cells, parathyroid glands and chromosomes.
If the aluminum were to be removed from such compositions, the strength increase would be much slower, rendering the cement useless for its intended applications.
A number of disadvantages limit the applications of the process, such as the need for hydrothermal treatment for formation of the hydroxyapatite, and the need for high pressure (28 MPa) pressing in order to achieve an adequately high strength.
Also, the process described by Ma et al can not be used for forming a uniform composite structure, and the mechanical strength was not signifi

Method used

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  • High strength biological cement composition and using the same
  • High strength biological cement composition and using the same
  • High strength biological cement composition and using the same

Examples

Experimental program
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Effect test

example 1

Preparation of Novel High Strength Biocement for Orthopedic Applications

[0072] In this example the phosphate silicate cement was prepared synthetically using well defined, substantially pure chemicals (as opposed to the poorly defined minerals utilized for preparation of the typical commercial Portland cements). The raw materials used were colloidal silica (50 wt % Ludox, from 3M company) for the SiO2 component, calcium hydroxide (99.9%, Sigma-Aldrich) for the CaO component, tetracalcium phosphate (Ca4(PO4)2O), and dicalcium phosphate anhydrate (CaHPO4.H2O) (Fisher). The designed composition was 65 wt % tricalcium silicate, 20 wt % dicalcium silicate, 10 wt % tetracalcium phosphate, and 5 wt % dicalcium phosphate.

[0073] A 200 g cement batch was prepared by mixing 96.32 g of colloidal silica, 160.98 g calcium hydroxide, and 300 g distilled water in a ceramic jar, followed by ball milling for 24 hours. The slurry of this mixture was dried by using a spray dryer, and then fired in hi...

example 2

Preparation and Properties of Phospho-Silicate Hydraulic Cement by Sol-Gel Process

[0075] This example utilized a sol-gel process to prepare high-purity, aluminum-free biocement. Tetraethylorthosilicate (TEOS), Ca(NO3)2 4H2O, triethyl phosphate (TEP) were used in the sol-gel method. Ca(NO3)2 4H2O was dissolved in 1M HNO3 solution and TEOS was added to the solution with vigorous stirring to obtain a nominal composition of 70 mol % CaO-30% SiO2. After 10-15 min of hydrolysis under stirring, a homogenous sol was obtained. The sol precursor was sealed in a container, where the precursor was allowed to gel for 1 day at room temperature and aged for another day at 70° C. The dry gel powder was obtained by heating the templated gel at 600° C. in air for 1 hour (heating rate: 2° C. / min). The dry powder was fired at 1400° C. for 2 hrs. The crystalline product was analyzed by X-ray diffraction (XRD). The results of XRD indicated that the product contained only the phases of tricalcium silicat...

example 3

Effect of Calcium Phosphate on the Properties and Microstructure of Biocement

[0078] In this example, biocement was prepared in the same manner as described in Example 1. The setting time of was about 1 hour to 4 hours, for a water / cement ratio of 0.25. The average compressive strength after 7-days incubation at 37° C. and 100% humidity was 104 MPa, with the standard deviation of 7 MPa, as shown in FIG. 1.

[0079] The X-ray diffraction pattern provided in FIG. 6 indicates that the set cement contained about 15% HAP, and about 8% Ca(OH)2. This is compared with the characteristics of the control samples without calcium phosphate material, hydrated under identical conditions as the above samples of biocement. The average compressive strength of calcium silicate control cement was 45 MPa, with a standard deviation of 5 MPa, again referring to FIG. 1. The X-ray diffraction pattern provided in FIG. 6 indicates that the set control sample contained no HAP, and about 20% of Ca(OH)2. The scan...

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Abstract

A hydraulic cement for biomedical applications. The cement sets in-situ, hardening when exposed to water to produce nano-dispersed composite of calcium-silicate-hydrate gel mixed with hydroxyapatite. In comparison with prior cements, the composition provides high biocompatibility, high bioactivity and high biomechanical strength, due to the composite structure of the calcium silicate hydrate reinforced with co-precipitated particles of hydroxyapatite. Biocompatibility is also increased due to an absence of aluminum and magnesium in the composition. The cement is suitable for variety of applications, including dental implants, bone fixation, and bone repair.

Description

RELATED CASES [0001] This application claims the priority of Provisional Patent Application Ser. No. 60 / 731,561, filed Oct. 31, 2005.BACKGROUND OF THE INVENTION [0002] a. Field of the Invention [0003] The present invention relates generally to hydraulic cements for medical and dental applications, and, more particularly, to an aluminum-and magnesium-free hydraulic cement that produces a nano-dispersed composite of calcium-silicate-hydrate gel mixed with hydroxyapatite, that exhibits good mechanical strength and high biocompatibility and bioactivity. [0004] b. Related Art [0005] Hydraulic cements are commonly utilized in construction and also in medical and dental applications. [0006] One of the most important hydraulic cements is calcium di-silicate and tri-silicate-based cement, which is widely used in construction. There are three main compounds in the cement: dicalcium silicate (C2S), tricalcium silicate (C3S), and calcium aluminate (C3A). Highly crystalline calcium hydroxide (Ca...

Claims

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Application Information

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IPC IPC(8): C04B28/34A61K33/42A61K33/06
CPCA61K6/033A61K33/06A61K33/42A61K45/06A61L24/02A61L27/04A61L27/12A61L27/425A61L27/50C04B7/345C04B12/027C04B28/18C04B28/34C04B28/346C04B2103/0067C04B2111/00836C04B2111/10C04B2111/80C04B22/16C04B12/025C04B14/062C04B14/308C04B14/365C04B22/064C04B14/306C04B14/043A61K6/0038A61K6/0612A61K6/0643A61K6/0675A61K6/54A61K6/838A61K6/853A61K6/876A61K6/864Y02P40/10
Inventor LU, DONGHUIZHOU, SHUXIN
Owner INNOVATIVE BIOCERAMIX
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