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Injectable composite bone cement of hydroxyapatite-PMMA containing strontium, preparation method and application thereof

A technology of strontium hydroxyapatite and hydroxyapatite, which is applied in the field of strontium-containing hydroxyapatite-PMMA injectable composite bone cement and its preparation, can solve the application limitations of traditional PMMA bone cement, low biological activity, and poor application Limitations and other issues, to achieve excellent biological activity and biocompatibility, good biocompatibility, and promote the effect of calcium deposition

Inactive Publication Date: 2011-01-05
马文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above deficiencies make the application of traditional PMMA bone cement subject to greater restrictions.
Especially in the field of spinal surgery, its application is very limited due to concerns about damage to the spinal cord due to excessive temperature and low biological activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 6.91g of phosphoric acid was continuously added to 0.2L of double distilled water containing 6.66g of calcium hydroxide and 2.65g of strontium hydroxide (with 8 crystal waters), stirred until the pH value reached 9.5, and the mixture was stirred for 24h. The mixture was filtered and dried at 100°C. Then calcined in an oven at 750°C for 3h. Pulverize into fine powder by a powder machine, and pass through a 70 μm sieve to obtain a mixture containing strontium hydroxyapatite.

[0036] 10.5g of the mixture containing strontium hydroxyapatite was added to the mixture of 60.75g of PMMA, 1.84g of BPO, 19.12g of PMMA / styrene copolymer and 9.06g of barium sulfate, and after fully stirring and mixing, the strontium-containing Hydroxyapatite-PMMA composite bone cement powder.

[0037] Add 50 g of a mixed solution of MMA and DMPT in a weight ratio of 98:2 (containing 0.0075% of hydroquinone by weight to the total weight of the two) into the bone cement powder, and stir for 1 min ...

Embodiment 2

[0039] Continue to add 7.32g of phosphoric acid to 0.25L of double distilled water containing 6.79g of calcium hydroxide and 2.77g of strontium hydroxide (with 8 crystal waters), stir to make it a suspension with a pH value of 9.5, and continue to stir The mixture 24h. The suspension was filtered to obtain a mixture, which was dried at 105°C. Then calcined in an oven at 800°C for 3h. Pulverize into fine powder by a powder machine, and pass through a 70 μm sieve to obtain a mixture containing strontium hydroxyapatite.

[0040] Add 15g of the mixture containing strontium hydroxyapatite to the mixture of 60.58g of PMMA, 1.656g of BPO, 19.06g of PMMA / styrene copolymer and 9.03g of barium sulfate, and stir to obtain strontium-containing hydroxyapatite Stone-PMMA composite bone cement powder.

[0041] Add 50 g of the mixed solution (containing 0.0075% hydroquinone accounting for 0.0075% of the total weight of both) of MMA and DMPT into the bone cement powder, and stir for 1 min u...

Embodiment 3

[0043] Continue to add 14.2g of phosphoric acid to 0.4L of double distilled water containing 13.75g of calcium hydroxide and 5.12g of strontium hydroxide (with 8 crystal waters), stir until it becomes a suspension with a pH value of 9.5, and continue stirring 24h. The mixture was obtained by filtration and dried at 110°C. Then calcined in an oven at 850°C for 3h. Grinding into fine powder by a powder machine, passing through a 70 μm sieve to obtain a mixture containing strontium hydroxyapatite.

[0044] Add 25g of the mixture containing strontium hydroxyapatite to 120.5g of PMMA, 3.52g of BPO, 40.02g of PMMA / styrene copolymer and 18.3g of barium sulfate mixture, and stir to obtain strontium-containing hydroxyapatite Stone-PMMA composite bone cement powder.

[0045] Add 100 g of the mixed solution (containing 0.0075% hydroquinone accounting for 0.0075% of the total weight of the two) of MMA and DMPT into the bone cement powder, and stir for 1 min under vacuum to make it Pol...

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Abstract

The invention discloses an injectable composite bone cement of hydroxyapatite-PMMA containing strontium, consisting of a powder and a liquid monomer with the weight ratio of 1.5 to 2.5:1, wherein the main components of the powder are 10 to 30% of hydroxyapatite containing strontium and 70 to 90% of PMMA and / or PMMA / styrene copolymer in percentage by weight, and the main components of the liquid monomer are 98 to 99.9% of MMA and 0.1 to 2% of DMPT in percentage by weight. The bone cement has the advantages of safety, no toxity, convenient operation and molding, and low polymerization temperature. The bone cement has good biomechanics intensity, biological activity and biocompatibility, and can promote the growth of the bone, suppress the bone resorption and be used in radiological imaging because of containing the metallic element of strontium.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a strontium-containing hydroxyapatite-PMMA injectable composite bone cement and a preparation method and application thereof. Background technique [0002] With the advent of an aging society, bone diseases (including osteoporosis, bone tumors, bone defects, etc.) and joint diseases (joint pain, tumors involving joints, etc.) Major diseases of the patient's quality of life (which can lead to disability), which can be caused by multiple factors such as trauma, severe infection, and congenital deformity. In the United States, about 1.5 million osteoporosis patients have fractures every year, of which spinal fractures account for 30%. Vertebral body fractures are mostly treated with vertebroplasty; in addition, artificial joint replacements for joint pain and joint tumors have been implemented every year. Reached about 700,000 cases (2004), including artificial hip joints...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/50
CPCA61L2430/02
Inventor 马文
Owner 马文
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