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Biological rack material for articular cartilage and its prepn process

A technology for articular cartilage and biological scaffold, which is applied in the field of biological material preparation, can solve the problems of fast degradation of scaffold materials, lack of mechanical strength, and difficulty in shaping, and achieves good tissue compatibility, low price, and easy results.

Inactive Publication Date: 2007-08-22
孔清泉
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  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that it lacks certain mechanical strength, is difficult to shape, and the scaffold material degrades too quickly in the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0019] Example: The specific preparation method of the articular cartilage bio-scaffold material with a weight ratio of natural cartilage matrix components and type II collagen of 4:1, a porosity of 90%, and an average pore diameter of 100 μm.

[0020] 1. Extract the extracellular matrix components of articular cartilage, and extract and process according to the following procedures:

[0021] 1) Take fresh pig articular cartilage, try not to get the subchondral bone part, weigh about 200g, use a lathe to grind it into debris with an average size of about 3mm×3mm.

[0022]2) Soak the cartilage debris in a large beaker filled with 0.5M HCl solution for 72 hours, remove the inorganic substances in the bone tissue components that may be mixed, and rinse with distilled water

[0023] 3) Take out the cartilage debris, put it into a large beaker filled with 35% hydrogen peroxide solution, shake and wash it continuously at 35-38°C for 36 hours, and rinse it with distilled water;

[0...

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PUM

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Abstract

The present invention relates to one kind of biological rack material for articular cartilage and its preparation process. The porous rack material for articular cartilage is prepared through mixing natural cartilage matrix component with the cell, antigen and type I and type X collagen eliminated and type II gollagen, and serial physical and chemical treatments with sodium chloride crystal grain as pore forming agent. The rack material has the components the same as those of natural cartilage, high biomechanical strength, high porosity, proper degradation speed, use convenience and no influence on the body's and local immunity. The present invention may be used in the clinical repair of articular cartilage defect and in vivo and in vitro construction of tissue engineering cartilage.

Description

field of invention [0001] The invention belongs to the technical field of biological material preparation, and relates to a preparation method of a novel blended articular cartilage bio-scaffold material and a product prepared by the method. Background technique [0002] Cartilage lacks the ability to regenerate, and cartilage defects caused by trauma or disease need to be repaired with cartilage or other materials. The source of autologous cartilage is limited, and it is easy to cause defects in the donor site, so its application is limited. Allogeneic cartilage has been widely used, because it can cause immune rejection, resulting in cell death and loss of function. Periosteal transplantation was once popular, but its long-term effect is not stable, so people continue to explore more perfect repair methods. The successful culture of chondrocytes in vitro has triggered people's attempts to directly use chondrocytes to repair cartilage defects. In 1968, Chertman et al. in...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/38
Inventor 孔清泉项舟李锋
Owner 孔清泉
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