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Cartilage deficiency prosthesis, preparation method thereof and integrated cartilage-bone repair material

A prosthesis and cartilage technology, applied in prosthesis, medical science, etc., can solve the problems of only focusing on natural cartilage, ignoring the natural cartilage matrix structure, unsatisfactory mechanical strength, etc., to prevent cartilage fibrosis and good biocompatibility. , the effect of stable mechanical strength

Inactive Publication Date: 2011-01-26
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still many defects in the reported artificial cartilage or cartilage repair scaffolds, the main manifestations are: ①Unsatisfactory mechanical strength; ②The number of new chondrocytes is too small, replaced by a large number of collagen fibers
The main reason is that at present, cartilage tissue engineering products lack a full understanding of the arrangement structure of natural cartilage matrix, and only focus on the matrix components of natural cartilage, while ignoring the matrix structure of natural cartilage

Method used

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  • Cartilage deficiency prosthesis, preparation method thereof and integrated cartilage-bone repair material
  • Cartilage deficiency prosthesis, preparation method thereof and integrated cartilage-bone repair material
  • Cartilage deficiency prosthesis, preparation method thereof and integrated cartilage-bone repair material

Examples

Experimental program
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Effect test

Embodiment 1

[0031] In this example, follow these steps:

[0032] 1) Dissolve type I collagen and chitosan powder in 0.2mol / l acetic acid solution respectively, and prepare respectively a type I collagen solution and a chitosan solution with a concentration of 20g / L, and centrifuge the two solutions for 5 minutes respectively After that, let stand to remove the air bubbles in the solution;

[0033] 2) Mix the above-mentioned type I collagen solution and the chitosan solution in a mass ratio of 1:3, and fully stir to obtain a mixed solution;

[0034] 3) Pour the above mixed solution into the mold, and quickly place it in the environment of -60°C to freeze and form it. After it is completely frozen, place it in a freeze dryer for 14 hours to freeze-dry to make a porous composite scaffold;

[0035] 4) Place the above-mentioned porous composite support in a fume hood to completely volatilize the residual acetic acid;

[0036] 5) At 2°C, place the above-mentioned porous composite scaffold in ...

Embodiment 2

[0039] In this example, follow these steps:

[0040] 1) Dissolve type II collagen and glycosaminoglycan powder in 0.2 mol / l acetic acid solution respectively, and prepare respectively a type II collagen solution and a glycosaminoglycan solution with a concentration of 20 g / L, and centrifuge the two solutions respectively After 15 minutes, let stand to remove the bubbles in the solution;

[0041] 2) Mix the above-mentioned type II collagen solution and the glycosaminoglycan solution at a mass ratio of 1:1, and stir thoroughly to obtain a mixed solution;

[0042] 3) Pour the above mixed solution into the mold, and quickly place it in the environment of -100°C to freeze and form it. After it is completely frozen, place it in a freeze dryer for 8 hours to freeze-dry to make a porous composite scaffold;

[0043]4) Place the above-mentioned porous composite support in a fume hood to completely volatilize the residual acetic acid;

[0044] 5) At 6°C, place the above-mentioned porou...

Embodiment 3

[0047] In this example, follow these steps:

[0048] 1) Dissolve type II collagen and chondroitin sulfate powder in 0.2 mol / l acetic acid solution, respectively, to prepare type II collagen solution and chondroitin sulfate solution with a concentration of 20g / L, and centrifuge the two solutions for 10 minutes respectively After that, let stand to remove the air bubbles in the solution;

[0049] 2) Mix the above-mentioned type II collagen solution and chondroitin sulfate solution in a mass ratio of 2:1, and stir thoroughly to obtain a mixed solution;

[0050] 3) Pour the above mixed solution into the mold, quickly place it in an environment of -80°C to freeze and shape it, and after it is completely frozen, place it in a freeze dryer for 10 hours to freeze-dry to make a porous composite scaffold;

[0051] 4) Place the above-mentioned porous composite support in a fume hood to completely volatilize the residual acetic acid;

[0052] 5) At 4°C, place the above-mentioned porous ...

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Abstract

The invention discloses cartilage deficiency prosthesis, a preparation method thereof and an integrated cartilage-bone repair material. The prosthesis is composed of collagen and proteoglycan based on the mass ratio of 1 / 3-3, wherein, the collagen is I-type collagen or II-type collagen, and the proteoglycan comprises glycosaminoglycan, chitosan or chondroitin sulfate; and natural cartilage matrixes are longitudinally arranged in the prosthesis. The integrated cartilage-bone repair material is made by compounding the prosthesis with a bone matrix material together. The cartilage defect prosthesis of an articular cartilage matrix structure of the invention can meet the repair need of articular cartilage deficiency, effectively improve repair rate of articular cartilage injury and lower disability incidence of a patient.

Description

technical field [0001] The invention belongs to the technical field of cartilage defect repair, and relates to a cartilage defect repair body and an integrated cartilage-bone repair material, in particular to a cartilage defect repair body with an articular cartilage matrix structure and a preparation method thereof, and a cartilage defect repair body based on the cartilage defect repair body. An integrated cartilage-bone repair material for prosthetics. Background technique [0002] Articular cartilage injury is a common clinical disease. Due to the low metabolic capacity of cartilage itself and its limited repair ability, even superficial cartilage damage as small as 4 mm cannot be repaired by itself. However, full-thickness cartilage damage involving subchondral bone can cause a spontaneous repair response; however, the repaired tissue is mostly fibrocartilage and connective tissue, and its biological properties and strength are far lower than those of natural articular ...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/36A61L27/44
Inventor 毕龙韩一生李丹黄兆松何树于龙
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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