Preparation method of self-repairing bionic low-friction hydrogel cartilago articularis on basis of agar

A technology of articular cartilage and hydrogel, applied in tissue regeneration, prosthesis, medical science, etc., can solve the problems of insufficient mechanical properties of hydrogel cartilage, no self-healing ability, etc., achieve good clinical application prospects, low cost, Effect of Low Coefficient of Friction

Inactive Publication Date: 2019-08-27
NANJING UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems of insufficient mechanical properties and no self-repair ability of traditional hydrogel cartilage

Method used

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  • Preparation method of self-repairing bionic low-friction hydrogel cartilago articularis on basis of agar

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preparation example Construction

[0021] The preparation method of the self-repairing biomimetic low-friction hydrogel articular cartilage based on agar of the present invention comprises the following steps:

[0022] (1) Agar was added into deionized water, and the temperature of the water bath was 97° C., stirred and dissolved to obtain an aqueous agar solution.

[0023] The specific method is: add 0.3363g agar to 15ml deionized water, and stir for 4 hours at a water bath temperature of 97°C;

[0024] 2) Then configure AAc, AAm, Fe 3+ solution, adding a crosslinking agent and a photoinitiator, adding the mixed solution into the agar solution and stirring evenly.

[0025] The specific method is: add AAc (0.6305g-1.3511g) and AAm (1.8659g-3.9983g) to 5ml of deionized water, so that the ratio of the molar weight of agar to the total molar weight of acrylic acid and acrylamide is 1:35-1 :75, the molar ratio of acrylic acid to acrylamide is 1:3, adding Fe(NO 3 ) 3 9H 2 O (0.0177g-0.0758g), so that the amount...

Embodiment 1

[0032] The solution was prepared in such a ratio that the amount of agar to the sum of the amounts of acrylic acid and acrylamide was 1:35, and the amount of iron ions was 0.5% of the amount of acrylic acid. First prepare a 0.05mol / L agar solution, stir in a water bath at 95°C for 4 hours to dissolve, then prepare AAc, AAm, Fe(NO 3 ) 3 9H 2 O, MBAA (0.0054g), KA (0.0051g) solution, shielded from light and stirred for 0.5 hours, then added it to the agar solution and stirred for 0.5 hours to obtain a uniform solution. The resulting mixed solution was injected into a glass mold, cooled to room temperature, and then irradiated with ultraviolet light for 1.5 hours to obtain agar / PAAc-PAAm-Fe 3+ Double network hydrogel articular cartilage. Compared with pure agar hydrogel 7MPa, the compressive modulus is increased by about 85%, the self-healing performance can be realized, the complete self-healing time is 2 days, and the friction coefficient is 0.09.

Embodiment 2

[0034] The solution was prepared in such a ratio that the amount of agar to the sum of the amounts of acrylic acid and acrylamide was 1:50, and the amount of iron ions was 0.75% of the amount of acrylic acid. First prepare a 0.05mol / L agar solution, stir in a water bath at 95°C for 4 hours to dissolve, then prepare AAc, AAm, Fe(NO 3 ) 3 9H 2 O, MBAA (0.0077g), KA (0.0073g) solution, protected from light and stirred for 0.5 hours, then added it to the agar solution and stirred for 0.5 hours to obtain a uniform solution. The resulting mixed solution was injected into a glass mold, cooled to room temperature, and then irradiated with ultraviolet light for 1.5 hours to obtain agar / PAAc-PAAm-Fe 3+ Double network hydrogel articular cartilage. Compared with pure agar hydrogel, the compressive modulus is increased by about 98%, the self-healing performance can be achieved, the complete self-healing time is 3 days, and the friction coefficient is 0.1.

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Abstract

The invention discloses a preparation method of self-repairing bionic low-friction hydrogel cartilago articularis on the basis of agar. The method includes the steps of adopting agar hydrogel as a physical cross-linking network and polyacrylic acid-polyacrylamide hydrogel as a chemical cross-linking network to form a double-layer network structure, and introducing iron ions to achieve a coordination effect with polyacrylic acid to prepare hydrogel with a porous aqueous structure. Dynamic reversible ionic coordination bonds and hydrogen bonds between the networks are utilized to endow the agar/polyacrylic acid-polyacrylamide-iron ion double network hydrogel with high self-repairing capability and mechanical performance. Compared with pure agar hydrogel, the agar/polyacrylic acid-polyacrylamide-iron ion double network self-repairing hydrogel cartilago articularis has the advantages that the compression modulus is increased by 80-120%, and good self-repairing performance is achieved.

Description

technical field [0001] The invention belongs to the technical field of implant devices, and relates to a method for preparing a self-repairing bionic low-friction hydrogel articular cartilage based on agar. Background technique [0002] Hydrogel is a kind of functional polymer material with a three-dimensional network structure formed by connecting hydrophilic polymer chains by means of chemical cross-linking and physical cross-linking. Show "soft" and "wet" characteristics. Due to the properties of hydrophilicity, biocompatibility, softness and toughness, hydrogels have great application prospects in the field of biological tissue engineering. [0003] Natural articular cartilage is mainly composed of water (accounting for 70-80% by weight) and extracellular matrix. The main component of extracellular matrix is ​​collagen that constitutes the fiber network, which endows articular cartilage with high strength and elasticity. The porous network structure can store synovial ...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24C08J3/28C08L33/26C08L5/12C08F220/56C08F220/06C08F222/38C08F2/48A61L27/52A61L27/20A61L27/16
CPCA61L27/16A61L27/20A61L27/52A61L2430/24C08F2/48C08F220/56C08J3/075C08J3/246C08J3/28C08J2333/26C08J2405/12C08L5/12C08L33/26C08F220/06C08F222/385
Inventor 许培刘昀彤熊党生
Owner NANJING UNIV OF SCI & TECH
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