A liquid-solid composite lubricant in joints and its preparation method

A compound lubricant and intra-articular technology, which is applied in the field of biomedical engineering, can solve the problems of ineffective reduction of cartilage friction damage and the insignificant effect of liquid lubricant on friction reduction, so as to achieve good anti-cartilage damage effect and restore knee joint function. , the effect of slowing down consumption
CN104383607BActive Publication Date: 2016-06-08天津中医药大学第一附属医院
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
天津中医药大学第一附属医院
Publication Date
2016-06-08

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Abstract

The invention discloses an intra-articular liquid-solid composite lubricating agent and a preparation method thereof. The preparation method comprises the following steps: adding graphene oxide to sodium hyaluronate, so that the concentration is 20-50mu g / ml; carrying out ultrasonic treatment for 0.5-2 hours at 15-60 DEG C for evenly dispersing. The lubricating agent disclosed by the invention is safe and reliable, and good in cartilage damage resistance; a uniform lubricating film is formed on the surface of a joint, so that the friction damage on the joint is effectively reduced, the joint motion is increased, and the function of a knee joint is restored; meanwhile, the graphene oxide can stably exist in a joint cavity in a living body for a long period of time, has ultra-strong adsorbability and good biocompatibility, and has adsorption and slow-release effects on sodium hyaluronate, so that consumption of sodium hyaluronate is relieved; sodium hyaluronate is capable of protecting cartilago articularis; the local symptom of the knee joint is significantly reduced; the injection frequency is obviously reduced; at least one injection is changed from continuous injection once a week for five weeks in the past; and the pain caused by injection for a plurality of times is relieved.
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Description

technical field

[0001] The invention belongs to the field of biomedical engineering, and in particular relates to a liquid-solid composite lubricant in a joint and a preparation method thereof. Background technique

[0002] Osteoarthritis, also known as degenerative arthritis, is a chronic disease. The main lesions are degeneration of articular cartilage and secondary hyperosteogeny. It is more common in middle-aged and elderly people, more women than men, and more common in weight-bearing joints.

[0003] There are many treatment methods, and non-surgical therapy is generally used in the early stage. Traditional treatment is mainly based on non-steroidal anti-inflammatory drugs (NASIDS), but long-term use can easily lead to gastrointestinal and kidney damage. At present, injecting sodium hyaluronate into the joint cavity has become a common method for the treatment of osteoarthritis. However, in clinical practice, some people still think that simple sodium hyaluronate inje...

Claims

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