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Intra-articular liquid-solid composite lubricating agent and preparation method

A compound lubricant and intra-articular technology, applied in the field of biomedical engineering, can solve the problems that liquid lubricants have no obvious anti-friction effect and cannot effectively reduce cartilage friction damage, etc., achieve good anti-cartilage damage effect and restore knee joint function , increase the effect of joint activity

Active Publication Date: 2015-03-04
天津中医药大学第一附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the development of natural science and technology, relevant clinical studies have proposed the application of intra-articular injection of ozone or Astragalus injection plus sodium hyaluronate, which has improved the injection materials to a certain extent, but the friction reduction effect of liquid lubricants when the articular surface is loaded and squeezed The effect is not obvious
Therefore, liquid lubricants are not effective in reducing cartilage friction damage under loaded conditions

Method used

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  • Intra-articular liquid-solid composite lubricating agent and preparation method
  • Intra-articular liquid-solid composite lubricating agent and preparation method
  • Intra-articular liquid-solid composite lubricating agent and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A method for preparing a liquid-solid composite lubricant in a joint, comprising the steps of:

[0023] Graphene oxide was prepared by the improved Hummers method, the graphene oxide was lamellar, the particle size was about 90nm, and the purity was 99.99%;

[0024] Graphene oxide was added to sodium hyaluronate with a molecular weight of 1.5 million to a concentration of 30 μg / ml, ultrasonicated for 0.5 h at 60°C to disperse evenly, and the composite lubricant was balanced to 25°C before use.

[0025] Male SD rats, weighing 200±10 g, were purchased from Tianjin Shanchuanhong Experimental Animal Technology Co., Ltd., license number SCXK (Jin) 2009-0001, production batch number: 20120617. Healthy male SD rats were selected, and their normal articular cartilage slices were as follows: figure 1 shown. According to 0.3g·kg -1 Body weight was anesthetized with 10% chloral hydrate ip, loaded with 35% poloxamer drug carrier and 4% papain to make thermosensitive in situ gel ...

Embodiment 2

[0028] A method for preparing a liquid-solid composite lubricant in a joint, comprising the steps of:

[0029] Using the Offeman method to prepare graphene oxide, the graphene oxide is lamellar, the particle size is about 110nm, and the purity is 99.9%;

[0030] Graphene oxide was added to sodium hyaluronate with a molecular weight of 800,000 to a concentration of 50 μg / ml, ultrasonicated for 1 hour at 20°C to disperse evenly, and the composite lubricant was balanced to 25°C before use.

[0031] Male SD rats, weighing 200±10 g, were purchased from Tianjin Shanchuanhong Experimental Animal Technology Co., Ltd., license number SCXK (Jin) 2009-0001, production batch number: 20120617. Choose healthy male SD rats, according to 0.3g·kg -1 Body weight was anesthetized with 10% chloral hydrate ip, loaded with 35% poloxamer drug carrier and 4% papain to make thermosensitive in situ gel controlled release agent, according to the dose of 0.05ml (1.6U) / joint, bilateral Inject into the k...

Embodiment 3

[0034] A method for preparing a liquid-solid composite lubricant in a joint, comprising the steps of:

[0035] Purchase non-toxic graphene oxide, graphene oxide is lamellar, the particle size is about 120nm, and the purity is 99.999%;

[0036] Graphene oxide was added to sodium hyaluronate with a molecular weight of 2.2 million to a concentration of 20 μg / ml, ultrasonicated for 2 hours at 15°C to disperse evenly, and the composite lubricant was balanced to 25°C before use.

[0037] Male SD rats, weighing 200±10 g, were purchased from Tianjin Shanchuanhong Experimental Animal Technology Co., Ltd., license number SCXK (Jin) 2009-0001, production batch number: 20120617. Choose healthy male SD rats, according to 0.3g·kg -1 Body weight was anesthetized with 10% chloral hydrate ip, loaded with 35% poloxamer drug carrier and 4% papain to make thermosensitive in situ gel controlled release agent, according to the dose of 0.05ml (1.6U) / joint, bilateral Inject into the knee joint, act...

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Abstract

The invention discloses an intra-articular liquid-solid composite lubricating agent and a preparation method thereof. The preparation method comprises the following steps: adding graphene oxide to sodium hyaluronate, so that the concentration is 20-50mu g / ml; carrying out ultrasonic treatment for 0.5-2 hours at 15-60 DEG C for evenly dispersing. The lubricating agent disclosed by the invention is safe and reliable, and good in cartilage damage resistance; a uniform lubricating film is formed on the surface of a joint, so that the friction damage on the joint is effectively reduced, the joint motion is increased, and the function of a knee joint is restored; meanwhile, the graphene oxide can stably exist in a joint cavity in a living body for a long period of time, has ultra-strong adsorbability and good biocompatibility, and has adsorption and slow-release effects on sodium hyaluronate, so that consumption of sodium hyaluronate is relieved; sodium hyaluronate is capable of protecting cartilago articularis; the local symptom of the knee joint is significantly reduced; the injection frequency is obviously reduced; at least one injection is changed from continuous injection once a week for five weeks in the past; and the pain caused by injection for a plurality of times is relieved.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and in particular relates to a liquid-solid composite lubricant in a joint and a preparation method thereof. Background technique [0002] Osteoarthritis, also known as degenerative arthritis, is a chronic disease. The main lesions are degeneration of articular cartilage and secondary hyperosteogeny. It is more common in middle-aged and elderly people, more women than men, and more common in weight-bearing joints. [0003] There are many treatment methods, and non-surgical therapy is generally used in the early stage. Traditional treatment is mainly based on non-steroidal anti-inflammatory drugs (NASIDS), but long-term use can easily lead to gastrointestinal and kidney damage. At present, injecting sodium hyaluronate into the joint cavity has become a common method for the treatment of osteoarthritis. However, in clinical practice, some people still think that simple sodium hyaluronate inje...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/02A61L31/14A61L31/16
Inventor 刘爱峰魏强危慕彬许伟泽
Owner 天津中医药大学第一附属医院
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