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Preparing method for infrared response high-strength hydrogel for cartilago articularis repair

An infrared response, cartilage repair technology, applied in medical science, prosthesis, etc., can solve problems such as unsuitability for cartilage repair, poor biocompatibility, toxicity of gold nanomaterials, etc., and achieve excellent biocompatibility, excellent biological Excellent compatibility and affinity

Inactive Publication Date: 2015-12-02
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are two major defects in the existing photoresponsive hydrogels: 1. The poor biocompatibility is not suitable for cartilage repair
For example, gold nanomaterials are toxic and cannot be implanted in the body; carbon nanotubes, graphene and their derivatives are inorganic substances of carbon, and long-term implantation has potential toxicity hidden dangers
2. Poor mechanical strength, not suitable for cartilage repair requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for preparing an infrared-responsive high-strength hydrogel for cartilage repair, the specific steps of which are as follows:

[0032] A. Double bond modification of chitosan

[0033] Fully dissolve chitosan in the buffer, then add glycidyl methacrylate to the buffer, so that the concentration of chitosan in the buffer is 10 mg / ml, and the concentration of glycidyl methacrylate is 2 mg / ml After 6h, sedimentation or dialysis, and then drying, can obtain chitosan containing double bond modification;

[0034] B. Preparation of Smart Hydrogels

[0035] B1. Dissolve polydopamine nanoparticles, N-isopropylacrylamide and the double-bonded modified chitosan obtained in step A together in deionized water to obtain a mixed solution. The concentration of polydopamine nanoparticles in the mixed solution is 0.1 mg / ml, the concentration of N-isopropylacrylamide is 80mg / ml, and the concentration of double bond modified chitosan is 200mg / ml;

[0036] B2. Add the cross-linki...

Embodiment 2

[0042] A method for preparing an infrared-responsive high-strength hydrogel for cartilage repair, the specific steps of which are as follows:

[0043] A. Double bond modification of carboxymethyl chitosan

[0044] Carboxymethyl chitosan is fully dissolved in the buffer, so that the concentration of carboxymethyl chitosan in the buffer is 12mg / ml, and NHS and carboxymethyl chitosan are added with 0.1 times the molar amount of carboxymethyl chitosan Sugar 0.1 times the molar amount of EDC; then add glycidyl methacrylate in the buffer solution, so that the concentration of glycidyl methacrylate in the buffer solution is 12mg / ml; after 24h, sedimentation or dialysis, and then drying, can obtain the Double bond modified carboxymethyl chitosan;

[0045] B. Preparation of Smart Hydrogels

[0046] B1. Polydopamine nanoparticles, N-isopropylacrylamide and the double bond modified carboxymethyl chitosan obtained in step A are dissolved together in the double bond modified carboxymethy...

Embodiment 3

[0053] A method for preparing an infrared-responsive high-strength hydrogel for cartilage repair, the specific steps of which are as follows:

[0054] A. Double bond modification of chondroitin sulfate

[0055] Fully dissolve chondroitin sulfate in the buffer, then add methacrylic anhydride to the buffer, so that the concentration of chondroitin sulfate in the buffer is 10 mg / ml, and the concentration of methacrylic anhydride is 60 mg / ml; dialyze after 20 hours , then dialyzed, and freeze-dried to obtain chondroitin sulfate modified with double bonds;

[0056] B. Preparation of Smart Hydrogels

[0057] B1. Polydopamine nanoparticles, N-isopropylacrylamide and the double-bonded modified chondroitin sulfate obtained in step A are dissolved in deionized water to obtain a mixed solution. The concentration of polydopamine nanoparticles in the mixed solution is 0.5mg / ml, the concentration of N-isopropylacrylamide is 150mg / ml, and the concentration of double bond modified chondroi...

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Abstract

The invention discloses a preparing method for infrared response high-strength hydrogel for cartilago articularis repair. The preparing method mainly includes the operation steps that polysaccharide or protein is modified in a double bond forming mode through methacrylic acid, methacrylic anhydride and methacrylate substances, so that the polysaccharide or the protein has a double-bond group in a side chain and is capable of being polymerized to form the hydrogel. Under the action of an initiator and a cross-linking agent, N-isopropyl acrylamide and the polysaccharide or the protein modified in the double bond forming mode form the double-network high-strength hydrogel through in-situ polymerization. The prepared infrared response high-strength hydrogel is high in biocompatibility and excellent in mechanical property and has good application prospects in the field of cartilago articularis repair.

Description

technical field [0001] The invention relates to a preparation method of an infrared-responsive high-strength intelligent hydrogel for articular cartilage repair. Background technique [0002] Hydrogel has a soft and elastic three-dimensional network structure, which can provide a microenvironment closer to the natural cartilage extracellular matrix for cell proliferation and differentiation, and is an ideal material for cartilage tissue repair. [0003] In the process of promoting cartilage repair, growth factors traditionally loaded in hydrogels cannot be released in a controlled manner according to repair needs, which is an important problem restricting the application of hydrogels in cartilage repair. In recent years, light-responsive hydrogels have attracted more and more attention because of their intelligence in sensing changes in the external environment and the release of external stimulus-response control factors. However, there are two major defects in the existin...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/22A61L27/20A61L27/18A61L27/50A61L27/52A61L27/54C08L5/08C08L5/04C08L79/02C08J3/24
Inventor 鲁雄张晏宁王振铭韩璐胥杰龙甘东林
Owner SOUTHWEST JIAOTONG UNIV
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