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Composite hydrogel as well as preparation method and application thereof

A technology of composite hydrogel and aqueous solution, applied in the field of biomedicine, can solve the problems of long time consumption, instability, molding failure, etc., and achieve the effects of simple and easy operation, good structural stability, and enhanced compressive strength.

Active Publication Date: 2022-08-09
BEIJING JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The number of freezing and thawing cycles has a great influence on the structural properties of the hydrogel; after one freezing and thawing, the structure of the hydrogel is in a transition state, the crystallinity is very low, and it is very unstable. Usually, after 3 to 5 cycles are completed, The crystallinity in the hydrogel tends to be stable, and the formed hydrogel network structure is relatively stable, which means that this preparation method requires a lot of time and takes a long time.
At the same time, the time and temperature of freezing and thawing will affect the phase balance between the hydrogel interface, resulting in molding damage and low efficiency.
[0005]Currently, it is difficult to meet the actual needs of human joints in terms of the macro-lubrication mechanism of bionic synovial fluid and the bearing and lubrication performance of bionic hydrogel materials. problems greatly limit the biomedical applications of these materials

Method used

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  • Composite hydrogel as well as preparation method and application thereof
  • Composite hydrogel as well as preparation method and application thereof
  • Composite hydrogel as well as preparation method and application thereof

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Embodiment 1

[0041] According to the molar ratio of SBMA and EGDMA being 5:2, the total mass of SBMA and EGDMA accounts for 75% of the total mass of the reaction mixture, the amount of APS added accounts for 0.05% of the total mass of the reaction mixture, and the monomer SBMA (279.35 g mol -1 , 2.5mol L -1 aqueous solution) (polymer chains as hydrogel network), crosslinker EGDMA (198.22 g mol -1 , 1mol L -1 aqueous solution) and initiator ammonium persulfate APS (228.20 g mol -1 , 0.22mol L -1 Aqueous solution), monomer GE (0%, 0.5%, 1.5%, 3%, 5%, 6%, GE concentration is the ratio of GE to the total mass of the reaction mixture), magnetic stirring at 600r / min at room temperature , after complete mixing, add accelerator tetramethylethylenediamine TMEDA (116.20g mol -1 , 80 μL) and continue to stir for 1 min to obtain the reaction mixture, which is then poured into the mold, and after standing for 10-30 min, the GE-PSBMA composite hydrogel in the shape of the mold is obtained. The obta...

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Abstract

The invention discloses composite hydrogel as well as a preparation method and application thereof. The composite hydrogel is prepared from methacrylate sulphobetaine, ethylene glycol dimethacrylate and glyceryl polyether through free radical polymerization and ester exchange reaction. According to the invention, GE is introduced into PSBMA hydrogel, new chemical crosslinking is generated through transesterification, a composite hydrogel network GE-PSBMA is formed, compared with pure PSBMA hydrogel, the GE-PSBMA composite hydrogel has the advantages that the compressive strength is obviously enhanced and is increased by nearly 40 times, the composite hydrogel has a low friction coefficient, and the composite hydrogel shows relatively good biocompatibility, hydrophilicity and thermal stability, and can be applied to the field of biomedical materials. The material has potential to become an articular cartilage substitute material.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a composite hydrogel and a preparation method and application thereof. Background technique [0002] Hydrogel has a three-dimensional network structure similar to natural articular cartilage, so it has a series of special mechanical properties, such as being able to withstand large deformation, good biocompatibility, stable chemical properties and good formability. Development offers great potential to be considered as a potential biocompatible material to replace native tissues such as articular cartilage, tendons and ligaments. In recent years, polymer hydrogels, such as double network (DN) hydrogels, zwitterionic copolymer (zwitterionic copolymer) hydrogels and nanocomposite hydrogels, have been deeply used in the repair of articular cartilage defects. Research. Zwitterionic hydrogels have attracted much attention due to their high hydrophilicity, high ion density, and...

Claims

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Application Information

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IPC IPC(8): C08F283/06C08F220/38C08F222/14A61L27/16A61L27/50A61L27/52
CPCC08F283/06A61L27/16A61L27/52A61L27/50A61L2430/06C08F220/387C08F222/102C08L51/08
Inventor 王仲楠孟凡杰张跃郭慧
Owner BEIJING JIAOTONG UNIV
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