83results about How to "Will not degrade" patented technology

The invention discloses preparation and application of exosome secreted by human derived blood or mesenchymal stem cell. The preparation process of exosome comprises: extracting mesenchymal stem cells from health-human body blood or a stem cell culture supernatant, performing in-vitro culture and amplification, and utilizing means such as low-temperature separation, purification and the like to prepare high-purity high-bioactivity exosome. The blood or mesenchymal stem cell secreted exosome is added into medicines, health-care products and cosmetics according to ratios for developing of products with bioactivity, is capable of effectively regulating and controlling body cell signal transduction, activating cell regeneration, enhancing health cell proliferation and differentiation capacity, further regulating physiologic restoration or removing damaged, pathologic and aged cells of a body, fundamentally changing body physiologic functions, and helping to generate anti-tumor treatment effect by adjusting cellular immunity. The blood or mesenchymal stem cell secreted exosome is applicable to fields of medical science, health care and beauty treatment, and has wide application prospect.

The invention provides a method for production of ethanol by continuous fermentation of immobilized yeast cells, and the method comprises the following steps: (1) a fiber material is attached to a support frame, and is filled into a bioreactor; (2) yeast cells are immobilized in the fiber material in the bioreactor; (3) a fermentation medium is added into the bioreactor to begin ethanol fermentation; (4) when glucose in the fermentation medium is consumed, a fermentation liquid flows out of the bioreactor, the ethanol is collected, the fermentation medium is added, and then the step (4) is repeated. The method uses the fiber material for immobilization of the yeast cells for continuous fermentation to produce the ethanol, the fiber material as an immobilization material is stably in property, non-toxic, and good in adsorption and mass transfer effects, can be repeatedly used, is easy to achieve continuous production of the ethanol, and in a continuous fermentation process can greatly improve the ethanol yield.

The invention discloses a polycaprolactone/calcium sulfate composite material and a preparation method thereof, belonging to the field of macromolecule modification. The method comprises the following steps: utilizing biosurfactant to carry out surface modification on anhydrous calcium sulfate or calcium sulfate whiskers; and adopting a coprecipitation and mould pressing method to prepare anhydrous calcium sulfate or calcium sulfate whiskers reinforced polycaprolactone composite material. The composite material prepared by the method in the invention has the advantages of high mechanical strength and adjustable performance, thereby laying a foundation for the application thereof.

The invention belongs to the field of solar cells and specifically discloses a method for preparing a novel inorganic hole transport layer material and application thereof. The application of the application of a MnS material as a hole transport layer material. The preparation method comprises the steps of setting parameters by using a vacuum coating machine with MnS powder as a source material such that the density of the material is 3.99 g/cm3, the Z factor is 0.94, performing evaporation under a vacuum environment with the evaporation rate 0.5 to 1.0 A/S to obtain a MnS layer by deposition.According to the invention, the MnS material is applied as the novel inorganic hole transport layer material, an environment-friendly inorganic hole transport layer material is obtained, the materialis applied to a device such as a perovskite solar cell device, while high photoelectric conversion efficiency can be ensured, the stability of a solar cell is greatly improved, and a compact MnS filmwith uniform nanoparticles is prepared by vacuum evaporation method for the first time by improving parameters and conditions used in the evaporation process.

The invention relates to a preparation method of poly (p-phenylene terephthalamide) (PPTA) fiber with high elongation at break, and belongs to the technical field of artificial fiber. The preparation method is characterized by after preparing a spinning solution by taking a PPTA polymer of which the logarithmic viscosity is 4.5 to 7.5 dl/g as a raw material and concentrated sulfuric acid of which the concentration is 96 to 100 percent as a solution, forming as-spun filaments through a spinneret plate by adopting a dry-jet wet-spinning technology, then entering a coagulating bath to realize coagulation forming, and winding fiber after coagulation forming into a product after washing, neutralizing, drying and oiling the fiber, wherein the filament tension is controlled to be 0.5g/d or lower during the processes of washing, neutralizing, drying, oiling and winding. The PPTA fiber with the high elongation at break has good impact resistance and good fatigue resistance, and is relatively suitable for the field of rubber composite materials and bulletproof composite materials.

The invention discloses a high temperature-resistant plastic composite material made of modified lignocellulose and a polymer, and specifically the modified lignocellulose has characteristics of being hydrophobic and high temperature-resistant, wherein the polymer belongs to thermoplastic polymer. The modified lignocellulose can improve a processing temperature (as high as 300 DEG C) of the composite material, and can be applicable to various polymers; and meanwhile, the high temperature-resistant plastic composite material prepared by the modified lignocellulose and the thermoplastic polymer can overcome a defect that the conventional composite material is expanded by absorbing moisture in a using process, and can restrain corrosion of microorganisms.

The invention discloses a preparation method for implantation-grade polyether ether ketone (PEEK). The preparation method comprises the following steps: step 1, filling weighed PEEK granule in a mould; step 2, heating the mould and the PEEK therein to a molten state; step 3: pressurizing the PEEK to 10 to 60MPa in the molten state; step 4, cooling down the PEEK in the pressure state of step 3 to realize full crystallization of the PEEK, and keeping the molten duration of the PEEK less than or equal to 30 minutes; and step 5, demoulding the cooled mould. Implantation-grade PEEK product processed by the preparation method has the advantages of complete crystallization, no degradation, high strength, high plasticity and no pollution.

An anti-aging adhesive for corrugated boxes, made of the following raw materials in parts by weight: 25-35 parts of potato starch, 15-30 parts of sweet potato starch, 5-10 parts of chlorosulfonated polyethylene rubber, 5-10 parts of nitrile rubber 10 parts, 8-9 parts of nano-graphene, 10-12 parts of talc, 7-14 parts of aluminum triacetylacetonate, 7-14 parts of propylene oxide phenyl ether, N-tert-butyl-2-benzothiazolium 7‑14 parts of sulfonamide, 0.5‑1.5 parts of cyclohexanone oxime, 6‑7 parts of linoleic acid, 45‑62 parts of water, 20‑26 parts of modified antioxidant. The adhesive of the present invention has very good anti-aging performance, will not degrade in an oxygen-enriched environment, will not open the glue under strong ultraviolet radiation, and has a service life 40-50% longer than that of ordinary adhesives, and the metal ions in the composition It forms strong ionic bonds with functional groups, making it more cohesive.

The invention discloses a mini-pill type nicergoline capsule and a preparation method thereof. The mini-pill type nicergoline capsule is a sustained-release preparation and is prepared from a capsule shell and a nicergoline mini-pill accommodated in the capsule shell, wherein the nicergoline mini-pill sequentially comprises an empty pill core, a main drug layer and a pigmented layer from inside to outside; the main drug layer accounts for 15-60 percent of the empty pill core, and the pigmented layer accounts for 0.5-1 percent of the total weight of the empty pill core and the main drug layer. The mini-pill type nicergoline capsule has the advantages of small stimulation to intestines and stomach, high utilization rate, high stability, less toxic or side effects and capability of fully releasing effective components in time.

The invention relates to a method for measuring free polysaccharide content in polysaccharide protein conjugate, which comprises the following steps: under ice bath conditions, adding a sodium deoxycholate solution into a conjugate stock solution with a certain concentration, mixing, standing, adding a trichloroacetic acid solution, evenly mixing, centrifugating, and taking the supernatant, wherein the supernatant is a sample A to be measured, and the conjugate stock solution to be measured is a sample B to be detected; respectively measuring polysaccharide contents a and b in the sample A and sample B by a chemical method or immunologic method; and calculating the free polysaccharide content in the conjugate according to the formula free polysaccharide content=a/b*100%.

The invention relates to a preparation method of cephalotin acid and belongs to the technical field of drug synthesis. In order to solve the existing problem that the environment is severely polluted and the reaction temperature is high, the invention provides the preparation method of cephalotin acid. The method comprises the following steps: on the premise of an organic alkali, carrying out reaction on 2-thiopheneacetic acid and trifluoroacetic succinimide at (-20-40 DEG C) to obtain a solution containing activated esters; and then carrying out condensation reaction on the solution containing activated esters and 7-ACA at 10-35 DEG C to obtain the cephalotin acid. The method provided by the invention has the effects that the reaction condition is mild, the beta-lactam compound is not degraded and the method is environment-friendly, and the process operation is simplified.

The invention discloses a method for preparing HMW (High Molecular Weight) p-aramid polymer through ternary co-condensation. The method comprises the following steps: 1, preparing an NMP (N-Methyl Pyrrolidone)-CaCl2 solvent system; 2, cooling the NMP-CaCl2 solvent system, and adding 3,4'-diaminodiphenyl ether and p-phenylenediamine under the protection of nitrogen, thus obtaining a p-phenylenediamine-NMP-CaCl2 solution system; 3, adding p-phthaloyl chloride in the p-phenylenediamine-NMP-CaCl2 solution system, thus obtaining a raw material solution system; carrying out first-step copolycondensation; 4, after colloid appears in a solution of the first-step copolycondensation, rising the reaction temperature, and carrying out second-step copolycondensation, thus obtaining the p-aramid polymer. According to the method disclosed by the invention, a two-step copolycondensation reaction method which is carried out at a high temperature after a low temperature is adopted, ordered proceeding ofreaction is ensured, increment of side effects is avoided, and the intrinsic viscosity of the obtained p-aramid polymer in a dissolved state is 1.95 to 2.13 dL/g.

The invention discloses a pellet type omeprazole enteric capsule and a preparation method thereof. The pellet type omeprazole enteric capsule is a sustained-release preparation, and is composed of a capsule shell and evenly mixed omeprazole pellets received in the capsule shell; each omeprazole pellet is composed of a blank pill core, a main drug layer, an isolation layer and an enteric layer in order from inside to outside, wherein the weight of the main drug layer accounts for 15-60% of that of the blank pill core, the weight of the isolation layer accounts for 10% of the total weight of the blank pill core and the main drug layer, the weight of the enteric layer accounts for 28-32% of the total weight of the blank pill core, the main drug layer and the isolation layer; besides, the enteric layers of 40-60% of omeprazole pellets are further coated with pigment layers; the weight of the pigment layer accounts for 0.5-1% of the total weight of the blank pill core, the main drug layer, the isolation layer and the enteric layer; the diameters of the blank pill cores are 0.8-1.0mm; the granularity of the omeprazole pellets is 14-20 meshes; each capsule contains 15-30mg of omeprazole. The pellet type omeprazole enteric capsule has the advantages of good acid resistance, sufficient active ingredient release without delay, good stability and the like.

The invention relates to a pharmaceutical composition containing PEGylated asparaginase. The composition comprises PEGylated asparaginase, sorbitol, a protective agent, a buffering agent and a surfactant; the protective agent is selected from mannitol, sucrose or lactose; and the buffering agent is selected from phosphate or Tris-HCl. The pharmaceutical composition containing PEGylated L-asparaginase is advantageous in that: after refrigeration, samples are not easy to degrade.

The invention relates to a preparation method of a high-voltage-resistant polymer solid-state electrolyte membrane and a preparation method of a lithium ion battery. The preparation method of the electrolyte membrane includes: adding functionalized HO-PPG500-OH and crosslinking agent NCO-PPO2300-NCO into chloroform, and pouring into a die for crosslinking to obtain a membrane after reaction for first preset time. The polymer solid-state electrolyte membrane which is highly crosslinked is synthesized, carbamate group-NHCOO- formed by reaction of -NCO and -OH is introduced into the polymer solid-state electrolyte membrane and has high dielectric constant and polarization density, and a powerful hydrogen bond system is formed in a whole polymer solid-state electrolyte membrane system, so thatan electrochemical stable window of electrolyte obtained by utilizing the polymer solid-state electrolyte membrane can reach 5V, electrochemical stability and mechanical performance are improved remarkably, and the polymer solid-state electrolyte membrane has extensive application prospect in the field of lithium ion system energy storage.

The invention provides a preparation method of a polycaprolactone/hydroxyapatite composite biological ceramic material. The preparation method comprises the following steps: (1) dissolving polycaprolactone, surfactants and cosurfactants in organic solvents to prepare oil phase solutions of polycaprolactone; (2) respectively adding calcium ion solutions and phosphate ion solutions to the oil phase solutions to prepare calcium ion emulsions and phosphate ion emulsions, mixing the calcium ion emulsions with the phosphate ion emulsions, and reacting at 30-60 DEG C for 24-48 hours to form a mixed emulsion of polycaprolactone/hydroxyapatite; (3) volatilizing the organic solvents in the mixed emulsion prepared in the step (2), washing and drying the mixed emulsion, and putting the obtained powder in a spark plasma sintering cavity to be sintered. The prepared composite biological ceramic material has the beneficial effects that the composite biological ceramic material has good dispersibility and high mechanical strength; the reaction temperature is relatively low, and hydroxyapatite can not be degraded, so that the composite biological ceramic material has higher bioavailability and is safer in production.

The invention belongs to the technical field of laying hen slaughtering, and particularly discloses a slaughtering and processing method for laying hens. The method comprises the following steps: hen selection: selecting adult laying hens with good growth and development conditions for later use; slaughtering: manually hanging the selected laying hens, firstly carrying out electric stunning, then clamping the heads of the hens by crossing the wings of the hens, and then carrying out pulse cutting and bloodletting on the necks of the hens to slaughter the laying hens; blood draining: after slaughtering, hanging the laying hens upside down and draining blood until no blood drips from cut places; and unhairing: conducting spraying and scalding with hot water having a temperature of 56-59 DEG C via a spraying machine to remove hair and residual film skin on the bodies of the hens. According to the invention, an original mode of cold water soaking for precooling is changed into the mode that the hens are precooled in a 0-DEG C constant-temperature precooling house without contacting with water, so the nutrition of the hens is not lost in the precooling process, and the acidity of meat quality is reduced, products are fresher and tenderer; bloodletting operation and blood draining are conducted after slaughtering of the whole hens, so problems in the appearance and color of the hen products are solved; and the spraying machine is adopted for hot water spraying and scalding, so original basin pool scalding is changed, spraying is uniform, scalding time is short, and nutrition is not lost.

The invention discloses a lithium sulfonate-containing ionic copolymer and a preparation method thereof. The lithium sulfonate-containing ionic copolymer comprises x mole parts of a polyvinylidene fluoride structural unit (A) composed of vinylidene fluoride monomers, y mole parts of an acrylate structural unit (B) composed of acrylate monomers and z mole parts of a perfluorovinyl ether lithium sulfonate structural unit (C) composed of perfluorovinyl ether lithium sulfonate monomers. The copolymer composed of the three compound structural units retains the advantage structure of polyvinylidenefluoride, so enough mechanical strength and thermal stability of the copolymer are ensured; by introducing a lithium ion high-efficiency transmission structural unit, a polar group and a large numberof super-stable structural units, the defects of the existing PVDF used as a polymer lithium ion battery material are overcome, the transmission efficiency of lithium ions is optimized, the ionic conductivity of a lithium battery is improved, the polarization of the battery in the charging process is reduced, and the charging and discharging performance of the battery is improved; and a new material and a new method are provided for further development and application of the lithium battery.

An atrianatriuretic peptide gene transfected cell microcapsule is disclosed, which can be transplanted in human body to durably release human atria natriuretic peptide for treating hypertension, heat failure and renal insuficiency. It features that the human atria natriuretic peptide gene transfected immortal cells (CHO cell, COS cell, etc) is encapsulated by polycaprolactone or polyurethane microcapsule.

The invention provides a method for preparing a polymethacrylate/hydroxyapatite composite biological ceramic material. The method comprises the following steps: (1) dissolving polymethacrylate, a surfactant and a cosurfactant into an organic solvent, so as to prepare an oil-phase solution of polymethacrylate; (2) respectively adding a calcium ion solution and a phosphate ion solution into the oil-phase solution, so as to prepare an emulsion and a phosphate ion emulsion, mixing the calcium ion emulsion and the phosphate ion emulsion, and reacting for 24-48 hours at the temperature of 40-80 DEG C, so as to form a polymethacrylate/hydroxyapatite mixed emulsion; (3) volatilizing the organic solvent in the mixed emulsion, washing with water, drying, so as to obtain powder, and sintering the obtained powder in a spark plasma sintering chamber. The composite biological ceramic material prepared by the method is good in dispersity, high in mechanical strength, relatively lower in reaction temperature, higher in bioavailability and safer in production, and hydroxyapatite cannot be degraded.

The invention provides a recombinant human growth hormone, and a construction method and application thereof, and belongs to the technical field of bioengineering. In the recombinant human growth hormone, hGH and RMP16 are connected through a connecting peptide (EAAAK) 5 to construct the recombinant human growth hormone which is marked as hGH-(EAAAK) 5-RMP16; the recombinant human growth hormone can be expressed in an escherichia coli prokaryotic expression system and has a self-efficient purification capability; and meanwhile, the recombinant human growth hormone can improve the stability of the hGH, prolong the half-life period of the hGH and increase the in-vivo residence time of the hGH so as to reduce administration frequency.

The invention discloses a special flame-retardant masterbatch for low carrier PBT and a preparation method thereof. A novel flame-retardant formula system is adopted, deep research and development iscarried out on PBT high-performance flame-retardant masterbatch, and the special flame-retardant masterbatch with low carrier, high GWIT and high CTI for PBT is researched and developed. Brominated polystyrene is taken as a main material, a phosphorus and nitrogen system flame retardant, antimony phosphate, pretreated PBT powder and a dispersing agent are added for preparation, wherein the dispersing agent consists of a lubricating agent PETS-T and esterified E wax, low-temperature liquid nitrogen grinding fabrication processing is carried out on PBT, the fusion with the component of the flame-retardant is more thorough, PBT powder is taken as the compound of the flame-retardant masterbatch, the special flame-retardant masterbatch for PBT can be rapidly fused with subsequent PBT resin, andan excellent flame-retardant effect is reached.