Method for preparing polymethacrylate/hydroxyapatite composite biological ceramic material

A polymethacrylate and composite bioceramic technology, applied in the fields of medical science, prosthesis, etc., can solve the problems of uneven particle distribution, low interface strength, low relative density, etc., achieve high bioavailability, and improve mechanical strength. , the effect of production safety

Inactive Publication Date: 2015-02-18
SUZHOU COSMETIC MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The melt blending method is simple and convenient to operate, but due to the certain viscosity of the polymer, it is difficult to fully disperse the filler particles inside the substrate, resulting in uneven particle distribution and low interface strength; the in-situ composite method can better improve the interface strength, but it is easy to Residual reaction impurities affect product performance; the solution casting method is to select a suitable solvent, add nano-inorganic particles to the polymer bulk solution, and remove the solvent after sufficient dispersion. The obtained composite material has good dispersion, but the relative density is low and the performance not guaranteed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Dissolve 10g of polymethacrylate, 5g of diethylene glycol monooleate and 1g of n-amyl alcohol into 50mL of ethanol to prepare an oil phase solution of polymethacrylate, and seal it for later use;

[0022] (2) Add 2 mL of 6 mol / L calcium nitrate solution dissolved with 0.1 g NaOH and 2 mL of 3 mol / L dipotassium hydrogen phosphate solution to 25 mL of the oil phase solution prepared in step (1) to form calcium ion emulsion and Phosphate ion emulsion, mixing calcium ion emulsion and phosphate ion emulsion, reacting at 40°C for 48 hours to form a mixed emulsion of polymethacrylate / hydroxyapatite;

[0023] (3) Ethanol in the mixed emulsion prepared in step (2) was volatilized in a fume hood, washed with water, dried, and the obtained powder was put into a discharge plasma sintering chamber, and an axial pressure of 70 MPa was applied at both ends, and the Vacuum, start heating when the pressure of the sintering chamber reaches 80Pa, the heating rate is 30°C / min, start di...

Embodiment 2

[0025] (1) Dissolve 30g of polymethacrylate, 8g of diethylene glycol fatty acid ester and 1g of isoamyl alcohol into 100mL of chloroform to prepare an oil phase solution of polymethacrylate, seal it for later use;

[0026] (2) Add 6mL of 6mol / L calcium nitrate solution and 6mL of 3mol / L dipotassium hydrogen phosphate solution respectively dissolved in 0.5gNaOH into 50mL of the oil phase solution prepared in step (1) to form calcium ion emulsion and Phosphate ion emulsion, mixing calcium ion emulsion and phosphate ion emulsion, reacting at 60°C for 40 hours to form a mixed emulsion of polymethacrylate / hydroxyapatite;

[0027] (3), volatilize the chloroform in the mixed emulsion prepared in step (2) in the fume hood, wash with water, dry, put the obtained powder into the discharge plasma sintering chamber, apply an axial pressure of 80 MPa at both ends, and pump Vacuum, start heating when the pressure of the sintering chamber reaches 80Pa, the heating rate is 40°C / min, start dis...

Embodiment 3

[0029] (1) Dissolve 60g of polymethacrylate, 12g of propylene glycol fatty acid ester and 1g of n-propanol in 200mL of carbon tetrachloride to prepare an oil phase solution of polymethacrylate, seal it for later use;

[0030] (2) Add 12mL of 6mol / L calcium nitrate solution dissolved with 1gNaOH and 12mL of 3mol / L dipotassium hydrogen phosphate solution to 100mL of the oil phase solution prepared in step (1) to form calcium ion emulsion and phosphoric acid Root ion emulsion, mixing calcium ion emulsion and phosphate ion emulsion, reacting at 70°C for 30 hours to form a mixed emulsion of polymethacrylate / hydroxyapatite;

[0031] (3) Volatilize the carbon tetrachloride in the mixed emulsion prepared in step (2) in the fume hood, wash with water, dry, put the obtained powder into the discharge plasma sintering chamber, apply 80MPa axial Pressure, vacuum, start heating when the pressure of the sintering chamber reaches 80Pa, the heating rate is 60°C / min, when the temperature rises ...

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PUM

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Abstract

The invention provides a method for preparing a polymethacrylate/hydroxyapatite composite biological ceramic material. The method comprises the following steps: (1) dissolving polymethacrylate, a surfactant and a cosurfactant into an organic solvent, so as to prepare an oil-phase solution of polymethacrylate; (2) respectively adding a calcium ion solution and a phosphate ion solution into the oil-phase solution, so as to prepare an emulsion and a phosphate ion emulsion, mixing the calcium ion emulsion and the phosphate ion emulsion, and reacting for 24-48 hours at the temperature of 40-80 DEG C, so as to form a polymethacrylate/hydroxyapatite mixed emulsion; (3) volatilizing the organic solvent in the mixed emulsion, washing with water, drying, so as to obtain powder, and sintering the obtained powder in a spark plasma sintering chamber. The composite biological ceramic material prepared by the method is good in dispersity, high in mechanical strength, relatively lower in reaction temperature, higher in bioavailability and safer in production, and hydroxyapatite cannot be degraded.

Description

technical field [0001] The invention relates to the field of biomaterials, in particular to a method for preparing a polymethacrylate / hydroxyapatite composite bioceramic material. Background technique [0002] Bone defects have always been a medical problem. At present, the ideal method is autologous or allogeneic bone grafting, and autologous bone grafting is widely regarded as the "gold standard" for measuring bone graft fusion. Although autologous bone grafting has many advantages, such as adapting to the regeneration of surrounding bone tissue, there are still some disadvantages, such as limited donors for autologous bone grafting, secondary trauma, increased surgical difficulty, and a certain failure rate. Allograft bone sometimes cannot stimulate osteogenesis, and often induces adverse reactions. Research on new bone substitute products has become a common problem faced by medical workers and material workers. [0003] Hydroxyapatite is the main inorganic component o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46
Inventor 陈晋纳喻国贞张帆
Owner SUZHOU COSMETIC MATERIALS
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