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Method for in-situ preparation of modified hydroxyapatite/polyvinyl alcohol nano-composite film

A technology of hydroxyapatite and polyvinyl alcohol, which is applied in the direction of single-component synthetic polymer rayon, rayon manufacturing, and fiber chemical characteristics, can solve the problems of easy agglomeration of HAP particles, and achieve improved interface compatibility, High bioactivity and compatibility, effect of solving aggregation problems

Inactive Publication Date: 2016-12-07
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a method for preparing modified hydroxyapatite / polyvinyl alcohol nanocomposite membrane in situ, which solves the problem that HAP particles are easy to agglomerate in the membrane preparation process, The in-situ cross-linking of the composite film has improved the strength, heat resistance and solvent resistance of the composite film, and the use of electrospinning technology makes the biofilm have a nano-scale structure, so that it has good biological characteristics and is resistant to proteins. Adsorption performance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Configure 0.5mol / L Ca(NO 3 ) 2 4H 2 O solution, 0.5mol / L Sr(NO 3 ) 2 Solution and 0.3 mol / L diammonium hydrogen phosphate solution were 50 mL each, and the pH value was adjusted to 10 with 28 wt % ammonia water. 47.775mL of Ca(NO 3 ) 2 4H 2 O solution and 0.975 mL of Sr(NO 3 ) 2 The solution was mixed evenly to obtain doped Sr(NO 3 ) 2solution of calcium nitrate. Then under the action of stirring, the calcium nitrate solution will be added to the 5wt% polyvinyl alcohol (9.789g) aqueous solution at a rate of 0.5mL / min, and added to the mixed solution at a rate of 1mL / min at 40°C. 48.75 mL of 0.3 mol / L diammonium hydrogen phosphate solution was added dropwise, and the stirring was continued for 12 h. Add maleic anhydride powder (the molar ratio of maleic anhydride to polyvinyl alcohol is 5:100) and the reaction catalyst polyphosphoric acid (that is, polyphosphoric acid) with a mass fraction of 0.1% (relative to polyvinyl alcohol) in the solution obtained by th...

Embodiment 2

[0035] Configure 0.33mol / L of Ca(NO 3 ) 2 4H 2 O solution, 0.33mol / L Mg(NO 3 ) 2 ·6H 2 O solution and 0.2 mol / L diammonium hydrogen phosphate solution were 50 mL each, and their pH value was adjusted to 10 with 28 wt % ammonia water. 46.8mL of Ca(NO 3 ) 2 4H 2 O solution and 1.95 mL of Mg(NO 3 ) 2 ·6H 2 The O solution was mixed evenly to obtain the doped Mg(NO 3 ) 2 solution of calcium nitrate. Then under the action of stirring, the calcium nitrate solution will be added to the 10wt% polyvinyl alcohol (9.838g) aqueous solution at a rate of 1mL / min, and added to the mixed solution at a rate of 2mL / min at 70°C. Add 48.75 mL of 0.2 mol / L diammonium hydrogen phosphate solution dropwise, and continue stirring for 24 h. Add maleic anhydride powder (the molar ratio of maleic anhydride and polyvinyl alcohol is 10:100) in the solution gained by reaction, and the reaction catalyst polyphosphoric acid (that is polyphosphoric acid) that mass fraction is 0.3% (relative to pol...

Embodiment 3

[0037] Configure 0.1mol / L Ca(NO 3 ) 2 4H 2 O solution, 0.1mol / L Zn(NO 3 ) 2 ·6H 2 O solution and 0.06 mol / L diammonium hydrogen phosphate solution were each 50 mL, and the pH value was adjusted to 10 with 28 wt % ammonia water. 45.825mL of Ca(NO 3 ) 2 4H 2 O solution and 2.925mL of Zn(NO 3 ) 2 ·6H 2 The O solution was mixed evenly to obtain doped Zn(NO 3 ) 2 solution of calcium nitrate. Then under the action of stirring, the calcium nitrate solution will be added to the 12wt% polyvinyl alcohol (9.9352g) aqueous solution at a rate of 1.5mL / min. 48.75 mL of 0.06 mol / L diammonium hydrogen phosphate solution was added dropwise, and the stirring was continued for 18 h. Add maleic anhydride powder (the molar ratio of maleic anhydride and polyvinyl alcohol is 15:100) in the solution gained by reaction, and the reaction catalyst polyphosphoric acid (being polyphosphoric acid) that mass fraction is 0.4% (relative to polyvinyl alcohol) h 6 P 4 o 13 ), after continuous ...

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Abstract

The invention relates to a method for in-situ preparation of a modified hydroxyapatite / polyvinyl alcohol nano-composite film. The method comprises the following steps: dropping a doped calcium nitrate solution to a polyvinyl alcohol water solution under a stirring condition, and then dropping a diammonium hydrogen phosphate solution and stirring at 40-70 DEG C for 12-24h, so that the in-situ generation of a doped modified hydroxyapatite / polyvinyl alcohol solution is achieved, wherein a calcium-phosphorus ratio is at 1.67; and then adding maleic anhydride and a catalyst, conducting stirring for 4-6h, so that a mixed solution is obtained, conducting electrostatic spinning, and drying an obtained film, so that the in-situ preparation of the modified hydroxyapatite / polyvinyl alcohol nano-composite film is achieved. The method disclosed by the invention is simple to operate; the interior of the film, which is prepared through in-situ cross-linking of the doped modified hydroxyapatite which is obtained from in-situ generation, has good dispersibility and stability, and meanwhile, the film has good biocompatibility; and the film, which can be used for separating and adsorbing a plurality of proteins, bio-enzymes as well as other bio-products, has a good adsorptive selectivity on the separation of the various proteins.

Description

technical field [0001] The invention belongs to the field of preparation of biomedical membrane materials, in particular to a method for preparing modified hydroxyapatite / polyvinyl alcohol nanocomposite membranes in situ. Background technique [0002] The molecular formula of hydroxyapatite (HAP) is Ca 10 (PO 4 ) 6 (OH) 2 , belonging to the hexagonal crystal system. It has good biocompatibility and can guide the regeneration of bone tissue. It mainly exists in human bones and teeth, and is a widely used biomaterial in medicine. What exists in human bone is not pure HAP, but also some other cations. By introducing zinc, magnesium, strontium, chromium, molybdenum and other human trace elements into HAP, the natural bone can be simulated to a greater extent. Polyvinyl alcohol (PVA for short) is a water-soluble polymer material that can be completely biodegraded. It is non-toxic to the human body, has no side effects, and has good biocompatibility. It is widely used in oph...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/44D01F1/10D01F6/50D04H1/4309D04H1/728
CPCA61L27/46A61L27/446D01F1/10D01F6/50D04H1/4309D04H1/728C08L29/04
Inventor 孙俊芬顾亚峰陈佳丽
Owner DONGHUA UNIV
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