39 results about "Bio products" patented technology

The invention belongs to the technical field of biological control, and particularly relates to a method for extracting a chemical substance with obvious activity on root-knot nematode. According to the method for extracting the chemical substance with the obvious activity on the root-knot nematode, the hedyotis diffusa sample is pretreated, impurities on the surface of the sample can be removed easily, and the purity of the subsequent active substance is improved; a sample is soaked in an ethanol solution with the volume concentration of 95%, effective active substances in the sample can be separated out easily, and effective chemical substances in the sample are promoted to be completely released through two times of ultrasonic extraction. Therefore, the chemical substance with obvious activity on the root-knot nematodes can be used for preventing and treating the root-knot nematodes or preparing biological products for preventing and treating the root-knot nematodes, not only is the death rate of the root-knot nematodes improved, but also green and health of plants are guaranteed, and the economic value of the plants is improved.

This invention relates to the application of the lola gene as a target in the control of fall armyworm, belonging to the field of biotechnology for pest control. It involves the application of the lola gene as a target in pest control or the preparation of biological products for pest control. Using the fall armyworm as the research object, this invention uses the lola gene as a molecular target, combines CRISPR / Cas9 gene editing technology, and develops a highly efficient sgRNA target site for its knockout. By utilizing the effect of Lola in inhibiting the production of female eggs in fall armyworms, its reproductive capacity is reduced, thereby achieving the purpose of control. This method is convenient to operate, effective, and sensitive, enabling long-term effective control of pest populations. It also significantly reduces the negative environmental impact of chemical pesticide use and avoids the risk of pests developing resistance due to long-term exposure to chemical pesticides, providing an innovative solution for sustainable agriculture.

To provide handheld biological analyzers and related biological analytics methods based on Raman spectroscopy.SOLUTION: A biological classification model configuration is loaded into a computer memory of a handheld biological analyzer. The biological classification model configuration includes a biological classification model configured to receive a Raman-based spectra dataset defining a biological product sample as scanned by a scanner. A spectral preprocessing algorithm is executed to reduce a spectral variance of the Raman-based spectra dataset. The biological classification model identifies a biological product type based on the Raman-based spectra dataset and further based on a classification component selected to reduce at least one of (1) a Q-residual error or (2) a summary-of-fit value of the biological classification model. The biological classification model configuration is transferrable to and loadable on other configurable handheld biological analyzers.SELECTED DRAWING: Figure 1

A biological product preservation apparatus (1) is described comprising: a container unit (100) for preserving a biological product; a thermal energy store (210); a thermoelectric modulation device (225), wherein the thermal energy store is thermally coupled to the container unit via the thermoelectric modulation device; and a controller (250) configured to control operation of the thermoelectric modulation device. Such apparatus may provide controlled thermal management and be robust to substantially differing ambient conditions or temperatures. A container unit and base unit are also disclosed, as are corresponding methods. These methods include the persufflation of tissue. Further embodiments are directed at one or more sensors configured to obtain an indication of a temperature of the thermal energy store and controlling operation of the apparatus based thereon, and at a container unit comprising a storage region for holding a liquid in which a biological product is to be preserved, wherein an agitator is provided to agitate liquid disposed in the storage region.

The present invention discloses a biocidal product for application to surfaces, particularly non-porous hard surfaces or the like, incorporating a luminescent identification marker which makes it possible to certify the presence of the product and therefore that protection is maintained, in addition to certifying its originality using luminescence encryption techniques. This biocidal composition enables its continuous disinfection action 24 hours a day, 7 days a week and is formed by the mixture of a biocidal composition and a luminescent additive dispersed therein, wherein the biocidal composition includes a mixture of biocidal agents formed by the combination of 0.5-5.0% dimethyl didecyl ammonium chloride and 0.5-5.0% dimethyloctadecyl[3-(trimethoxysilyl)propyl] ammonium chloride of a biocidal nature and a silver ion solution preferably consisting of silver phosphate glass in a proportion of 0.1-1%, and the luminescent additive includes aluminosilicate metal oxides containing rare earth ions as dopants.

The invention provides a composite membrane which combines polytetrafluoroethylene (PTFE) nano-particles and zirconium oxide (ZrO2) nano-crystals, and the surface energy of the composite membrane is effectively reduced, so that the microbial adhesion of the composite membrane in fermentation liquor is reduced. The ZrO2 nanocrystals can form small holes, so that the blockage and adsorption of protein are reduced, and the membrane pollution in the fermentation liquor is further relieved. The dual defense mechanism obviously improves the stable flux of the composite membrane in the ethanol fermentation liquor, and widens the application prospect of the composite membrane in fermentation liquor clarification and biological product recovery.

The invention discloses an anti-beta-lactamase antibody or an antigen binding fragment thereof, a biological product and application thereof, and relates to the technical field of immunoassay detection. The antibody has high binding affinity with beta-lactamase and can recognize CTX-M-1 type beta-lactamase, in addition, the invention further provides another antibody paired with the antibody, the two antibodies are used as a coating antibody and a detection antibody, beta-lactamase detection can be achieved with high sensitivity, and the antibody can be used for detecting CTX-M-1 type beta-lactamase. The invention provides a core material for a high-performance immunoassay detection method of beta-lactamase, and can be used for developing biological products such as reagents, kits, test strips, antibody chips, antibody probes or detectors. The rapid detection of beta-lactamase is facilitated to a great extent, and the method has a good application prospect in beta-lactamase residue and bacteria detection and in-vitro sample detection.

The present application provides a biological product and a method and an application thereof. The biological product is used for the preparation of a therapeutic agent for cancer treatment, and it includes at least one of the recombinant butyrylcholinesterase-albumin (rBChE-albumin) fusion protein and the recombinant butyrylcholinesterase-Fc (rBChE-Fc) fusion protein. The biological product adjusts the balance of acetylcholine and other related metabolic pathways by supplementing at least one of the exogenous rBChE-albumin fusion protein and rBChE-Fc fusion protein to treat cancer. The present invention solves the problem that the extraction and purification of BChE from human serum may not meet the huge demand for cancer treatment. The present application further provides a biological product for neutralizing and degrading nerve agents and organophosphate compounds, hydrolyzing ghrelin, and anti-wrinkle.

Biological product preservation apparatus 1 comprising: container unit 100 for preserving biological product; thermal energy store 210; thermoelectric modulation device 225, wherein thermal energy sto

Configurable handheld biological analyzers and related biological analytics methods are described for identification of biological products based on Raman spectroscopy. A biological classification model configuration is loaded into a computer memory of a configurable handheld biological analyzer having a processor and a scanner. The biological classification model configuration includes a biological classification model configured to receive a Raman-based spectra dataset defining a biological product sample as scanned by the scanner. A spectral preprocessing algorithm is executed to reduce a spectral variance of the Raman-based spectra dataset. The biological classification model identifies a biological product type based on the Raman-based spectra dataset, wherein a variable is selected to reduce at least one of (1) an error or (2) a summary-of-fit value of the biological classification model. The biological classification model configuration is transferrable to and loadable on other configurable handheld biological analyzers.

The invention relates to the field of microbial engineering, in particular to an engineering modified bacillus and a construction method and application thereof. The engineered bacillus comprises a MreB protein fused with a mutated ssrA tag protein at the C-terminal, and the engineered bacillus does not express an SspB protein. The volume of the engineering modified bacillus provided by the embodiment of the invention can be increased to more than 5 times of the volume of a wild type in the later growth period. When the engineering modified bacillus is used for preparing biological products through fermentation, the production efficiency can be remarkably improved.

The present disclosure provides methods and compositions for targeting lipid bilayer particles, such as secreted extracellular vesicles and cargo entities contained therein, to recipient cells.

The application provides a composite membrane combining polytetrafluoroethylene (PTFE) nanoparticles and zirconium oxide (ZrO2) nanocrystals, the surface energy of the composite membrane is effectively reduced, thereby reducing the microbial adhesion in the fermentation broth. The ZrO2 nanocrystals can form small pores, reducing protein plugging and adsorption, and further relieving membrane pollution in the fermentation broth. This double defense mechanism significantly improves the stable flux of the composite membrane in the ethanol fermentation broth, and widens the application prospect of the composite membrane in fermentation broth clarification and biological product recovery.

A biocidal product for application to surfaces, particularly porous surfaces such as fabrics, textiles and the like, incorporating an identification marker which makes it possible to certify the presence of the product and therefore that protection is kept. This biocidal composition includes an ester vinyl resin between 0.01 and 0.05% with respect to the total weight of the product, which acts as a carrier for the biocidal agents, a mixture formed by the combination of between 0.1 and 2.0% dimethyl didecyl ammonium chloride and between 2.0 and 10.0% dimethyloctadecyl [3-(trimethoxysilyl)propyl] ammonium chloride in a medium formed by the mixture of 0.2 to 1.0 methanol and 0.02 and 1.50 ethanol, urea in a proportion between 0.2 and 1.0% and acetic acid between 0.001 and 0.010; and the luminescent additive incorporates aluminosilicate metallic oxides containing rare earth ions by way of doping agents.

The invention relates to the field of microbial engineering, in particular to an engineering modified bacillus and a construction method and application thereof. The engineered bacterium comprises an MreB protein fused with a mutated ssrA tag protein at the C-terminal, does not express an SspB protein, and overexpresses a cell division inhibiting gene. The volume of the engineering modified bacillus provided by the embodiment of the invention can be increased to 10 times of that of a wild type in the later growth period. When the engineering modified bacillus is used for preparing biological products through fermentation, the production efficiency can be remarkably improved.

This invention provides the use of compounds of formula (I) as defined herein for detecting the concentration of aluminum ions in biological products such as, for example, aqueous antibody compositions.

The present invention relates generally to methods for producing products by cells, in particular to the field of industrial biotechnology or microbiology, in which useful chemicals and products, such as biological products such as proteins, are produced using living cells. The present invention relates to a method of producing a product by a cell, the method comprising: excising one or more nucleic acid sequences from a chromosome in the cell wherein the one or more nucleic acid sequences comprise a gene of interest and a starting point of replication; forming a DNA molecule outside the chromosome, wherein the DNA molecule outside the chromosome comprises a resected target gene and a replication starting point which are resected; and inducing expression of the target gene from the DNA molecule outside the chromosome. The invention also relates to cells for producing the product, polynucleotide vectors and uses thereof.

The utility model provides a packaging machine, which relates to the technical field of biological product packaging machines and comprises a packaging machine body, a sterilization box mounted on one side of the top of the packaging machine body, an inlet and an outlet which are formed in two sides of the outer end of the sterilization box, and a packaging component arranged on one side of the sterilization box, the packaging assembly comprises a packaging machine, a fixing plate, an electric push rod, an upper heating plate, a supporting rod, a lower heating plate and sterilization assemblies arranged at the top end and the bottom end in the sterilization box. The packaging assembly of the packaging machine can conduct hot pressing packaging on a packaging bag containing bouillon culture medium test tubes, the test tubes are prevented from falling out of the interior of the packaging bag, transportation is convenient, meanwhile, the test tubes can be prevented from being exposed outside and polluted by bacteria, and the surface and the bottom face of the packaging bag can be irradiated through the sterilization assembly for sterilization treatment; by means of the biological product packaging machine, biological product packaging meets strict sanitary requirements, it is guaranteed that products are sterile before being used, packaging and sterilization integrated treatment is achieved on the biological products, the working intensity is reduced, and time and labor are saved.

The utility model provides a fermentation device for biological product research and development, which relates to the technical field of biological product fermentation, and comprises a fermentation tank, a protection tank arranged on the outer side of the fermentation tank, a separation tank arranged on the top of the protection tank, and a dismounting assembly arranged between the separation tank and the protection tank and used for dismounting the separation tank, the dismounting assembly comprises a side plate, a through hole, a threaded rod and a nut, a purification assembly is arranged at the top of the separation tank, is used for purifying gas discharged from the fermentation tank and comprises a purification box, a purification frame and activated carbon particles. According to the fermentation device for biological product research and development, the separation tank is convenient to disassemble and assemble through the disassembling and assembling assembly, so that the stirring block is convenient to clean after the separation tank is disassembled, fermentation waste is prevented from remaining on the outer side of the stirring block, and the sealing performance in the separation tank and the protection tank is ensured through a cover plate and a connecting plate; therefore, anaerobic fermentation of biological product raw materials in the fermentation tank can be ensured, and gas discharged from the protection tank and the separation tank can be purified through the purification assembly.

The present disclosure features methods, cells or cell lines, and compositions for increasing the amount of products, e.g., proteins, produced by a cell or cell line by reducing the level of a non-essential endogenous protein.

Biological product preservation apparatus comprising container unit 100 comprising a storage region for holding a liquid in which a biological product is to be preserved and an agitator 146 configured

The invention relates to a method for operating a biological process plant (1) for producing biological products, in which the biological process plant (1) comprises a source container (2) for cell culture, a harvest container (3) for biological production and a clarification arrangement (4) with a centrifuge (12), in which the source container (2) is operated in a circulating production mode, the circulating production mode comprises the following steps: a) initiating the circulating production mode in the source container (2), b) culturing the cells in the source container (2), thereby obtaining a cell culture fluid (7) comprising the cultured cells, c) discharging a discharge portion (16) of the cell culture fluid (7) from the source container (2), d) combining a restart portion (17) of the cell culture fluid (7) with a fresh culture medium (8) and repeating step b), e) repeating steps c) and d) at least once, and / or f) discharging the cell culture fluid (7) obtained from step d) from the source container (2) in which the cyclic production mode is stopped, obtaining a discharged portion (16), wherein the method further comprises the steps of i) centrifuging the discharge portion (16) via the centrifuge (12), thereby separating the discharge portion (16) into at least a centrifuged discharge portion (19) and a supernatant (14) and, preferably, a biological product, ii) operating the harvest container (3) in a production mode wherein steps i) and ii) are performed at least twice.

The present invention relates to transfection reagent compositions and transfection compositions comprising such transfection reagents, which are suitable for the production of biological products. The present invention relates to a transfection reagent composition and a transfection composition suitable for use in the production of biological products wherein the transfection reagent composition comprises (i) at least one compound of general formula (I) or a tautomer, meso, raceme, enantiomer, diastereoisomer or mixture thereof, and (ii) an acceptable excipient, buffer, cell culture medium or transfection medium, wherein R, Z and P + are as described in the specification. The invention also relates to the in vitro or ex vivo use of said at least one compound of general formula (I), to a method for in vitro or ex vivo use comprising said composition, and to a method for purifying, detecting and / or quantifying said at least one compound of general formula (I).

The present invention relates to mammalian serum free of RNA, which can be used for cell culture or for the production of pharmaceutical biological products, since this fact preserves their supplementary properties. Another embodiment of the present invention relates to a method for removing RNA from mammalian serum, the method comprising applying successive steps of serum heating, alkalinization and neutralization.

The invention discloses an enzyme preparation for catalyzing fruit color enhancement and quality improvement and application of the enzyme preparation, and relates to the technical field of biological enzyme preparations and fruit and vegetable color enhancement and quality improvement. The enzyme preparation is a catalytic enzyme preparation which is prepared from a strain CH18 through a specific fermentation process, contains three ways of anthocyanin synthesis, has broad spectrum, and can be used for preparing a high-quality enzyme preparation for fruit color enhancement and quality improvement. The color enhancing agent has a color enhancing effect on red fruits, vegetables and color leaves. The fruit coloring and reddening agent is sprayed on the surfaces or leaf surfaces of fruits for 1-3 times, can catalyze the coloring and reddening of the fruits, and can be used for coloring fruits such as apples, red dates, winter dates, tautumn sweet persimmons, grapes, cherries, haws, tomatoes, peaches and the like and reddening colored leaves such as maple leaves and the like. The enzyme preparation belongs to a biological product, does not contain harmful substances, and ensures the quality improvement and safety of agricultural products.

The present invention relates to a method and system for monitoring biological products, and also to a method for generating a prediction of microbial load in biological products, comprising at least one synchronous electronic sensor (1) equipped with a data transmission device (11) in data communication with a gateway (2) via wireless networks and designed to be positioned near to or in direct contact with a biological product (7); or at least one asynchronous sensor (1') equipped with a removable storage unit (11'); a gateway (2) connected via the internet (3) to the data management module (4), wherein said module (4) comprises a trained artificial neural network and a data storage unit (42) both operated in a virtual environment from a cloud server (5) or on a local physical server (5') and connected to the user interface unit (6).

The present invention relates to a method for targeted generation of degradants from a biological product exposed to a low pH stress, wherein said method comprises a) selecting a set of different low pH stress conditions, wherein each stress condition is determined by a combination of a low pH and at least two additional factors, b) exposing said biological product to each low pH stress condition of said set, c) analyzing the degradants obtained in each low pH stress condition, d) processing the data obtained from said analysis, to obtain a predictive model of the degradants generated in function of the low pH and of the at least two additional factors and e), optionally, determining from said predictive model, a combination of values or ranges of values of low pH and of the at least two additional factors to be used to generate desired degradants from said biological product exposed to a low pH stress.

Provided herein are systems and methods for the separation of polyvinyl chloride-coated wiring into its component parts through the use of biological products to degrade the polyvinyl chloride. Methods can include the incubation of wire waste with microbes or enzymes to dechlorinate the polyvinyl chloride for enhanced separation of the polyvinyl chloride from the wire's interior.

To provide a method of determining an amount of cryoprotectant to be added to a biological product prior to cryopreservation.SOLUTION: A method comprises: a. determining the total surface area of an approximated geometry of the biological product, including an initial amount of cryoprotectant, to be cryopreserved; b. estimating thermal properties of the sample; c. performing computational fluid dynamics analysis on the sample within the apparatus; d. determining an average temperature reduction rate of the core of the sample at a predetermined sample surface temperature and corresponding heat exchange fluid flow rate to obtain the average temperature reduction rate; and e. if the fluid flow rate calculated at step (d) corresponds to a pump duty of the apparatus that is below a predetermined pump duty, selecting an amount of cryoprotectant that is a predetermined amount less than the initial amount to define a new initial amount.SELECTED DRAWING: None