19 results about "Bio products" patented technology

A biological product preservation apparatus (1) is described comprising: a container unit (100) for preserving a biological product; a thermal energy store (210); a thermoelectric modulation device (225), wherein the thermal energy store is thermally coupled to the container unit via the thermoelectric modulation device; and a controller (250) configured to control operation of the thermoelectric modulation device. Such apparatus may provide controlled thermal management and be robust to substantially differing ambient conditions or temperatures. A container unit and base unit are also disclosed, as are corresponding methods. These methods include the persufflation of tissue. Further embodiments are directed at one or more sensors configured to obtain an indication of a temperature of the thermal energy store and controlling operation of the apparatus based thereon, and at a container unit comprising a storage region for holding a liquid in which a biological product is to be preserved, wherein an agitator is provided to agitate liquid disposed in the storage region.

The present invention discloses a biocidal product for application to surfaces, particularly non-porous hard surfaces or the like, incorporating a luminescent identification marker which makes it possible to certify the presence of the product and therefore that protection is maintained, in addition to certifying its originality using luminescence encryption techniques. This biocidal composition enables its continuous disinfection action 24 hours a day, 7 days a week and is formed by the mixture of a biocidal composition and a luminescent additive dispersed therein, wherein the biocidal composition includes a mixture of biocidal agents formed by the combination of 0.5-5.0% dimethyl didecyl ammonium chloride and 0.5-5.0% dimethyloctadecyl[3-(trimethoxysilyl)propyl] ammonium chloride of a biocidal nature and a silver ion solution preferably consisting of silver phosphate glass in a proportion of 0.1-1%, and the luminescent additive includes aluminosilicate metal oxides containing rare earth ions as dopants.

The present application provides a biological product and a method and an application thereof. The biological product is used for the preparation of a therapeutic agent for cancer treatment, and it includes at least one of the recombinant butyrylcholinesterase-albumin (rBChE-albumin) fusion protein and the recombinant butyrylcholinesterase-Fc (rBChE-Fc) fusion protein. The biological product adjusts the balance of acetylcholine and other related metabolic pathways by supplementing at least one of the exogenous rBChE-albumin fusion protein and rBChE-Fc fusion protein to treat cancer. The present invention solves the problem that the extraction and purification of BChE from human serum may not meet the huge demand for cancer treatment. The present application further provides a biological product for neutralizing and degrading nerve agents and organophosphate compounds, hydrolyzing ghrelin, and anti-wrinkle.

Biological product preservation apparatus 1 comprising: container unit 100 for preserving biological product; thermal energy store 210; thermoelectric modulation device 225, wherein thermal energy sto

The invention relates to the field of microbial engineering, in particular to an engineering modified bacillus and a construction method and application thereof. The engineered bacillus comprises a MreB protein fused with a mutated ssrA tag protein at the C-terminal, and the engineered bacillus does not express an SspB protein. The volume of the engineering modified bacillus provided by the embodiment of the invention can be increased to more than 5 times of the volume of a wild type in the later growth period. When the engineering modified bacillus is used for preparing biological products through fermentation, the production efficiency can be remarkably improved.

The invention relates to the field of microbial engineering, in particular to an engineering modified bacillus and a construction method and application thereof. The engineered bacterium comprises an MreB protein fused with a mutated ssrA tag protein at the C-terminal, does not express an SspB protein, and overexpresses a cell division inhibiting gene. The volume of the engineering modified bacillus provided by the embodiment of the invention can be increased to 10 times of that of a wild type in the later growth period. When the engineering modified bacillus is used for preparing biological products through fermentation, the production efficiency can be remarkably improved.

This invention provides the use of compounds of formula (I) as defined herein for detecting the concentration of aluminum ions in biological products such as, for example, aqueous antibody compositions.

The present invention relates generally to methods for producing products by cells, in particular to the field of industrial biotechnology or microbiology, in which useful chemicals and products, such as biological products such as proteins, are produced using living cells. The present invention relates to a method of producing a product by a cell, the method comprising: excising one or more nucleic acid sequences from a chromosome in the cell wherein the one or more nucleic acid sequences comprise a gene of interest and a starting point of replication; forming a DNA molecule outside the chromosome, wherein the DNA molecule outside the chromosome comprises a resected target gene and a replication starting point which are resected; and inducing expression of the target gene from the DNA molecule outside the chromosome. The invention also relates to cells for producing the product, polynucleotide vectors and uses thereof.

Biological product preservation apparatus comprising container unit 100 comprising a storage region for holding a liquid in which a biological product is to be preserved and an agitator 146 configured

The present invention relates to transfection reagent compositions and transfection compositions comprising such transfection reagents, which are suitable for the production of biological products. The present invention relates to a transfection reagent composition and a transfection composition suitable for use in the production of biological products wherein the transfection reagent composition comprises (i) at least one compound of general formula (I) or a tautomer, meso, raceme, enantiomer, diastereoisomer or mixture thereof, and (ii) an acceptable excipient, buffer, cell culture medium or transfection medium, wherein R, Z and P + are as described in the specification. The invention also relates to the in vitro or ex vivo use of said at least one compound of general formula (I), to a method for in vitro or ex vivo use comprising said composition, and to a method for purifying, detecting and / or quantifying said at least one compound of general formula (I).

The present invention relates to a method and system for monitoring biological products, and also to a method for generating a prediction of microbial load in biological products, comprising at least one synchronous electronic sensor (1) equipped with a data transmission device (11) in data communication with a gateway (2) via wireless networks and designed to be positioned near to or in direct contact with a biological product (7); or at least one asynchronous sensor (1') equipped with a removable storage unit (11'); a gateway (2) connected via the internet (3) to the data management module (4), wherein said module (4) comprises a trained artificial neural network and a data storage unit (42) both operated in a virtual environment from a cloud server (5) or on a local physical server (5') and connected to the user interface unit (6).

The present invention relates to a method for targeted generation of degradants from a biological product exposed to a low pH stress, wherein said method comprises a) selecting a set of different low pH stress conditions, wherein each stress condition is determined by a combination of a low pH and at least two additional factors, b) exposing said biological product to each low pH stress condition of said set, c) analyzing the degradants obtained in each low pH stress condition, d) processing the data obtained from said analysis, to obtain a predictive model of the degradants generated in function of the low pH and of the at least two additional factors and e), optionally, determining from said predictive model, a combination of values or ranges of values of low pH and of the at least two additional factors to be used to generate desired degradants from said biological product exposed to a low pH stress.

The invention relates to the technical field of biological product manufacturing, and discloses an animal-derived peptide preparation method and application, the animal-derived peptide preparation method comprises the steps of raw material pretreatment, enzymolysis, purification, decoloration, debitterizing, concentration, drying and finished product detection which are carried out in sequence, the raw material pretreatment comprises the steps of raw material cleaning, crushing, liquid preparation and gradient low-temperature ultrasonic treatment; raw material cleaning: washing with flowing clear water for 3-5 times, cleaning the surface of hard raw materials such as ox bones by using a scrubbing brush, soaking soft tissue raw materials such as pigskin for 10-15 minutes, and then washing; through gradient low-temperature ultrasonic pretreatment, active ingredients are prevented from being damaged by high temperature while cell structures of the raw materials are damaged, and the extraction rate is increased by 15-20% compared with that of a traditional method; the composite enzymolysis system is combined with real-time monitoring, so that the enzymolysis efficiency is improved by 20-25%, and the active peptide yield is improved by 10-15%; the double-membrane coupling purification process synergistically removes macromolecular impurities and micromolecular salts, the purification efficiency is improved by 30-40%, the cost is reduced by 20-25%, and the product purity can reach 90% or above.

The invention discloses an antibody targeting respiratory syncytial virus F protein and application thereof, the antibody can specifically bind to the respiratory syncytial virus F protein, has high binding activity, and can be used for developing related biological products, such as detection reagents and detection kits, especially products for respiratory syncytial virus detection and diagnostic products, and the like. The antibody provided by the invention can be used for various detection methods such as ELISA detection, immunochemiluminescence detection, immunofluorescence detection and the like, and has the advantages of wide application range, strong applicability and the like.

A method of synthesizing a biological product (1) is presented. The method comprises (S1) supplying process water (2) to a pipe arrangement (10) with a plurality of pipe sections (11ij), wherein the pipe sections (11) are cascaded in a descending order, (S2) providing microalgae (3) to the process water (2), (S3) retaining the microalgae-enhanced process water (2, 3) in and letting it run through the pipe sections (11) consecutively, wherein the process water (2, 3) first enters an elevated pipe section (1111) and then enters a lower pipe section (1112) driven by gravity, and (S4) exposing the process water (2) in the pipe sections (11ij) to an irradiation (4) such that the microalgae (3) are allowed to grow under the irradiation (4), wherein a part of the water (H2O) evaporates. Moreover, a related pipe arrangement is presented.

Configurable handheld bioanalyzers and related bioanalysis methods for Raman spectroscopy-based identification of biological products using integrated artificial intelligence (A1) are described. The bioclassification integrated model configuration (103) is loaded into a computer memory (108) of a configurable handheld bioanalyzer (102) having a processor (110) and a scanner (106). The biological ensemble classification model configuration includes a biological classification ensemble model having an unsupervised model and a supervised model. The processor is configured to receive a Raman-based spectral data set defining a biological product sample as scanned by the scanner and execute a spectral pre-processing algorithm configured by a biological ensemble classification model to reduce spectral deviations of the Raman-based spectral data set. The biological ensemble classification model identifies a biological product type based on a Raman-based spectral data set.

Systems and devices for filtering biological products and methods of using the same are provided. The filtration system may include a filtration carriage configured to engage with a component of a single use assembly to facilitate one or more unit operations of a continuous filtration process of one or more biological products. The filter carriage may include a pump cart and a filter cart. The filter cart may include a first filter support assembly configured to support the first filter flow channel and a second filter support assembly configured to support the second filter flow channel.

This invention discloses a method and system for coupled biotransformation functional organism stress-induced circular aquaculture and zero wastewater discharge. The method first lays a granular absorbent carrier on a multi-layer aquaculture device to form a carrier layer, then sprays organic wastewater onto it to adsorb and form a moist biofilm. Subsequently, a biotransformation functional organism capable of converting organic matter is introduced into the carrier layer, and suitable humidity is maintained through cyclic spraying, driving the organism to consume pollutants and undergo biotransformation. Finally, the system separates and recovers the transformed biological products and reusable carrier. This invention breaks with the traditional concept that wastewater treatment is a cost center. Through process innovation, driven and realized by a single time-controlled ventilation and humidity control system, the wastewater treatment process itself is transformed into a value-added link that simultaneously produces high-value biological products. This not only solves environmental problems but also creates significant economic benefits, achieving a unity of environmental and economic benefits.

Biological product preservation apparatus 1 comprising: container unit 100 for preserving biological product; thermal energy store 210 coupled to container unit for managing temperature of said biolog