System and method for producing blood platelets

A technology of platelets and substrates, applied in the field of producing biological products, systems for producing biological products, devices for producing biological products, and the formation of microfluidic paths between the respective inlet and outlet channels, which can solve the problem of uneven platelet release, failure, etc. problems, to achieve the effect of rapid assembly and disassembly, and efficient production

Active Publication Date: 2018-07-17
THE BRIGHAM & WOMEN S HOSPITAL INC
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Also, cell cultures were unsuccessful in presynchronized platelet production, resulting in uneven platelet release over the course of 6-8 days, which correlates with platelet shelf life

Method used

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  • System and method for producing blood platelets
  • System and method for producing blood platelets
  • System and method for producing blood platelets

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Embodiment Construction

[0041]The present invention provides systems and methods for efficient and large-scale production of platelets and other biological products.

[0042] now refer to figure 2 , shows a schematic diagram of an exemplary system 100 for producing platelets and other biological products. In general, the system 100 includes a biological source 102, a bioreactor assembly 104, and an output 106, wherein the biological source 102 and output 106 are connectable to respective inputs and outputs of the assembly 104, respectively.

[0043] In particular, biological source 102 is configured with various capabilities to introduce different biological source materials, substances, gases or fluid media into assembly 104 to effectively produce a desired biological product, such as platelets. For example, biological source 102 may include one or more pumps for delivering or maintaining fluid media in bioreactor assembly 104 . Examples include microfluidic pumps, syringe pumps, peristaltic pump...

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Abstract

A system and method for generating biological products is provided. In some aspects, the system includes a first substrate having formed therein a plurality of inlet channel extending substantially along a longitudinal direction, and a second substrate having formed therein a plurality of outlet channel corresponding to the plurality of inlet channel and extending substantially along the longitudinal direction, the second substrate configured to releasably engage the first substrate. The system also includes a permeable membrane, arranged between the substrates, forming microfluidic pathways between respective inlet and outlet channels and configured to selectively capture biological source material capable of generating biological products, wherein at least one channel is tapered transversally to control a pressure differential profile regulating perfusion through the permeable membrane.

Description

[0001] Cross References to Related Applications [0002] This application is based upon and claims the rights of US Provisional Application No. 61 / 215,369, entitled "Platelet Bioreactor," filed September 8, 2015, which is incorporated herein by reference in its entirety. [0003] Statement Regarding Federally Funded Research [0004] This invention was made with government support under R00HL114719 awarded by the National Institutes of Health. The government has certain rights in this invention. Background of the invention [0005] The present invention relates generally to fluidic systems, including microfluidic devices, systems incorporating such devices, and methods of using such devices and systems. More specifically, the present invention relates to devices, systems and methods for producing biological products. [0006] Platelets, or thrombus cells, are irregular disc-shaped fragments of cells that circulate in the blood and are essential for hemostasis, angiogenesis,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/19
CPCA61K35/19C12M23/04C12M23/16C12M23/40C12M25/02C12M29/10C12M35/04C12M41/00C12N5/0644
Inventor J·N·索恩
Owner THE BRIGHAM & WOMEN S HOSPITAL INC
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