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Method for preparing nano-hydroxyapatite-protein artificial bone imitation materials

A nano-hydroxyapatite and protein technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of low content of organic components, waste of raw materials, and unsatisfactory content ratio of organic and inorganic components in natural bone, etc., to achieve The effect of simple process, easy operation and good controllability

Active Publication Date: 2016-05-25
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Common STR cannot provide efficient mixing and reaction, and the content of organic components in composite materials is generally low, which does not meet the content ratio of organic and inorganic components in natural bone, and also causes waste of raw materials

Method used

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  • Method for preparing nano-hydroxyapatite-protein artificial bone imitation materials
  • Method for preparing nano-hydroxyapatite-protein artificial bone imitation materials
  • Method for preparing nano-hydroxyapatite-protein artificial bone imitation materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A kind of preparation method of nano-hydroxyapatite material (does not contain albumen), comprises the steps:

[0047] Prepare 2L each of 0.1mol / L calcium nitrate and sodium phosphate solutions, adjust the calcium nitrate to pH = 10 with sodium hydroxide solution, and feed into the rotary The packed bed was reacted at room temperature, and the rotating speed of the packed bed was 1600r / min; the reacted suspension was aged at room temperature overnight, filtered, washed, and dried at 80°C for 10 hours. The product was ground into powder, poured into a mold, and pressed for 5 minutes under a pressure of 5 MPa to form a nano-hydroxyapatite material column with a diameter of 13.1 mm and a height of 10.5 mm. The nano-hydroxyapatite prepared in this example is short rod-shaped grains, with an average diameter of 9.6±2.1nm, an average length of 35.9±10.5nm, and an organic content of zero. The pressure of the cylindrical material obtained by die-casting is 0.3Gpa .

Embodiment 2

[0049] A preparation method of nano-hydroxyapatite-gelatin artificial bone-like material, comprising the steps of:

[0050] Prepare 2L each of 0.1mol / L calcium nitrate and sodium phosphate solutions, add 2.244g gelatin to the calcium nitrate solution, stir until the gelatin is completely dissolved and mix evenly, and adjust the pH to 10 with sodium hydroxide solution, and use calcium nitrate-gelatin The feed flow rate of solution 67.5L / h and sodium phosphate 40.5L / h was passed into the rotary packed bed, and reacted at room temperature, and the rotating speed of the rotary packed bed was 1600r / min; Filter, wash, and dry at 80°C for 10 hours. The product was ground into powder, poured into a mold, and pressed for 5 minutes under a pressure of 5 MPa to form a nano-hydroxyapatite-gelatin composite column with a diameter of 13.1 mm and a height of 10.3 mm. The nano-hydroxyapatite-gelatin composite material prepared in this embodiment is a short rod-shaped grain, with an average d...

Embodiment 3

[0052] A preparation method of nano-hydroxyapatite-gelatin artificial bone-like material, comprising the steps of:

[0053] Prepare 2L each of 0.1mol / L calcium nitrate and sodium phosphate solutions, add 5.05g gelatin to the calcium nitrate solution, stir until the gelatin is completely dissolved and mix evenly, and adjust the pH to 10 with sodium hydroxide solution, and use calcium nitrate-gelatin The feed flow rate of solution 67.5L / h and sodium phosphate 40.5L / h was passed into the rotary packed bed, and reacted at room temperature, and the rotating speed of the rotary packed bed was 1600r / min; Filter, wash, and dry at 80°C for 10 hours. The product was ground into powder, poured into a mold, and pressed for 5 minutes under a pressure of 5 MPa to form a nano-hydroxyapatite-gelatin composite column with a diameter of 13.2 mm and a height of 11.8 mm. The nano-hydroxyapatite-gelatin composite material prepared in this embodiment is a short rod-shaped grain, with an average di...

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Abstract

The invention discloses a method for preparing nano-hydroxyapatite-protein artificial bone imitation materials. The method includes steps of respectively preparing Ca(NO3)2 solution and Na3PO4 solution, dissolving proteins in the Ca(NO3)2 solution, controlling feeding according to a certain calcium-phosphorus molar ratio and carrying out reaction in a rotary packed bed; ageing reacted precipitates at the room temperature; carrying out pumping filtration on the precipitates and washing, drying and grinding the precipitates to obtain nano-hydroxyapatite-protein composite materials; pouring the ground composite materials into cylinder tablet compressing molds and carrying out pressure casting on the composite materials to obtain the cylindrical materials. The method has the advantages that high-gravity technologies and co-precipitation in-situ synthesis processes are combined with one another, so that the nano-hydroxyapatite-protein artificial bone imitation materials with high organic contents can be efficiently prepared; reaction conditions such as the concentration of raw components and the rotational speeds of the rotary packed bed are controlled, so that the artificial bone imitation materials can be prepared; the method is high in efficiency and low in cost, equipment is simple, techniques are safe and stable, the nano-hydroxyapatite-protein artificial bone imitation materials are high in organic content and can be produced under regulation and control, the proteins which are raw material are universal, and a novel way is provided for producing biological materials on a large scale.

Description

technical field [0001] The invention relates to the field of preparation of artificial bone-like materials. More specifically, it relates to a preparation method of nano-hydroxyapatite-protein artificial bone-like material. Background technique [0002] Due to the increase in various diseases such as tumors and rickets, and frequent accidents such as car accidents, the problem of bone damage is becoming more and more serious. Bone grafting can prevent the filling of fibrous tissue and facilitate the growth of new bone, thereby treating bone damage. There are usually three sources of bone grafts: autologous bone, allogeneic bone, and artificial bone material. Artificial bone materials can not only solve the problem of shortage of autologous bone sources but also have no disadvantages of immune rejection of allogeneic bone, and are excellent materials for solving bone damage problems. The composition of natural bone tissue consists of about 70% inorganic components and abou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/50
CPCA61L27/425A61L27/50A61L2430/02
Inventor 吕珊珊王洁欣孙宝昌罗勇陈建峰彭晗
Owner BEIJING UNIV OF CHEM TECH
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