Method for preparing high dispersibility nano-hydroxyapatite

A nano-hydroxyapatite, high-dispersibility technology, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve the problems of reducing the quality of hydroxyapatite, increasing energy consumption and cost, and expensive equipment. Achieve the effect of regular shape, easy operation and low price

Inactive Publication Date: 2009-04-15
SOUTHWEST JIAOTONG UNIV
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

The nano-hydroxyapatite powder prepared by the above method rarely has the characteristics of high dispersion, and usually after drying, it will be pulverized by a ball mill or a jet mill, and these two equipments are expensive, which increases the manufacturing cost; and some The hydroxyapatite prepared by the method is weakly crystalline, such as the sol-gel method, which must be further sintered to obtain crystalline hydroxyapatite, and it is difficult to avoid agglomeration during the sintering process, which not only increases energy consumption and cost but also reduces Hydroxyapatite Quality
In addition, some preparation methods have no waste or the waste cannot be recycled, which not only increases the cost but also causes environmental pollution

Method used

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  • Method for preparing high dispersibility nano-hydroxyapatite
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  • Method for preparing high dispersibility nano-hydroxyapatite

Examples

Experimental program
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Effect test

Embodiment 1

[0011] According to the calcium-phosphorus ratio of 1.67, weigh 9.44g of calcium nitrate tetrahydrate, dissolve in 20ml of water, add 10ml of ethylenediamine, heat to 60°C, and stir until the calcium nitrate is completely dissolved; weigh 1.7g of phosphorus pentoxide, dissolve in 10ml of water, stir until phosphorus pentoxide is completely dissolved. Stir the phosphorus pentoxide solution, slowly drop the calcium nitrate solution into the phosphorus pentoxide solution, and continue stirring after the dropwise addition is completed. Pour the mixed solution into a Teflon beaker liner with a total volume of 50ml, put it into a stainless steel autoclave, heat it to 180°C, keep it warm for 24 hours, and cool it at room temperature after the heat preservation is over. Ethanol was used as a lotion, and the centrifugal washing was performed several times until the product was washed neutral. The product was dried in a drying cabinet at 60°C. Thus obtained highly dispersed hydroxyapa...

Embodiment 2

[0014] Weigh 9.44g of calcium nitrate tetrahydrate, dissolve in 90ml of water, add 30ml of ethylenediamine, stir until clarified; weigh 1.7g of phosphorus pentoxide, dissolve in 80ml of water, put into a water bath or Heat to 90°C in a constant temperature heating mantle. Slowly drop the calcium nitrate solution into the phosphorus pentoxide solution at a constant temperature of 90°C under vigorous stirring, a white precipitate is produced, and continue to stir after the dropwise addition is completed. Then, the mixed solution after the dropwise addition was continued to be kept at 90° C. for 2 h. After the heat preservation, it was cooled at room temperature and aged for 1 day. The cleaning and drying process is the same as in Example 1, and nano-hydroxyapatite with finer grains is obtained.

Embodiment 3

[0016] Weigh 9.44g of calcium nitrate tetrahydrate, dissolve it in 20ml of water, add 10ml of ethylenediamine, heat to 60°C to increase the solubility, and stir until clarification; weigh 3.1616g of diammonium hydrogen phosphate and dissolve it in 10ml of water according to the calcium-phosphorus ratio of 1.67 , stirred to a clear solution, and the rest of the process was the same as in Example 1 to obtain highly dispersed nano-hydroxyapatite.

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Abstract

The invention discloses a preparation method of nanometer hydroxylapatite with high dispersivity, which prepares the nanometer hydroxylapatite by taking a phosphorus compound and a calcic compound as raw materials through a solvent hot method. The method comprises the following technical steps of: (1) dissolving calcium salt in 5-75 percent organic diamine hydrosolvent ; (2) preparing a phosphide hydrosolvent according to a calcium-phosphorus ratio of 1.67; and (3) adding the calcium salt solution in the step (1) into the phosphide hydrosolvent obtained from step (2), stirring and mixing, then heating to 180 DEG C, preserving temperature for 24 hours, cooling, centrifugate-washing the obtained precipitate to be neutral by using distilled water or absolute ethyl alcohol as a lotion, drying in a drying box at the temperature of 60 DEG C, and then obtaining the hydroxylapatite powder product with high dispersivity. Compared with the prior art, the product obtained by the method has good dispersivity and is crystalline state directly without sinter crystallization, and the method has brief technology, simple equipment, simple and convenient operation, recoverable waste liquor, controllable particle size and broad application prospect.

Description

technical field [0001] The invention relates to the field of preparation of nano functional ceramic powder, in particular to a synthesis method of highly dispersed nano hydroxyapatite. Background technique [0002] Hydroxyapatite is the main inorganic component of human tissue. It has good biocompatibility and biological activity, that is, it has no toxicity to tissues and cells, no inflammation and rejection, and the surface of the material is suitable for cell adhesion and growth. After implanted in the body, it can form a good bone bond with the surrounding bone tissue. Therefore, hydroxyapatite has been widely used in bone tissue engineering as a scaffold material and bone repair material. In addition, hydroxyapatite also has the characteristics of organic compatibility, strong protein adsorption capacity, and temperature-sensitive and humidity-sensitive effects with changes in temperature and humidity. Therefore, according to its different characteristics, hydroxyapatit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32C04B35/447
Inventor 汪建新张建达鲁雄翁杰周绍兵冯波屈树新卢晓英
Owner SOUTHWEST JIAOTONG UNIV
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