Microsphere tissue engineering scaffold used in beauty filling, and preparation method of microsphere tissue engineering scaffold

Abstract

The invention relates to a microsphere tissue engineering scaffold used in beauty filling, and a preparation method of the microsphere tissue engineering scaffold, and belongs to the field of tissue engineering scaffold materials. The method comprises the following processing steps: (1) preparing polyurethane microspheres: feeding isocyanate monomers and oligomer divalent alcohol into a reaction vessel, carrying out 1.5 to 3.5 h's reaction under 70 to 90 DEG C, feeding hydrophilic chain extender, viscosity modifier and catalyst, heating till the temperature is 45 to 55 DEG C, and carrying out reaction for 3 to 4 h; feeding the reaction liquid into salt forming agent solution in a high-speed stirring manner, shearing and emulsifying for 1 to 3.5 h, cleaning the microspheres with deionized water, and carrying out vacuum freeze drying; (2) preparing a polyurethane microsphere scaffold: dispersing the polyurethane microspheres in NaCl solution to form uniform emulsion, pouring the emulsion into a die, and carrying out freeze drying under -50 to -20 DEG C; and (3), conducting mineralization treatment on the surface of the scaffold: fixing the polyurethane microsphere scaffold in calcium-phosphorus supersaturated solution containing urease in a slowly stirring manner, carrying out mineralization treatment for 2 to 24 h, cleaning the scaffold for 2 to 24 h with deionized water, and carrying out freeze drying.

Description

technical field [0001] The invention belongs to the field of tissue engineering scaffold materials, in particular to a microsphere tissue engineering scaffold for cosmetic filling and a preparation method thereof. Background technique [0002] In recent years, microsphere materials have been widely used as filling materials for cosmetic injections. Because no incision is required during the operation, the operation is simple, the patient suffers less pain, and meets the needs of modern people for minimally invasive plastic surgery, so microsphere materials are widely used by patients once they are applied. welcome. However, the fluidity of the microsphere material is relatively large, and it cannot be confined to the required position as expected before the operation, and may be wrapped with the body to form granulation tissue; when complications occur after the operation, it is very difficult to remove the prosthesis , so its application is limited. Microsphere materials ...

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Problems solved by technology

However, the fluidity of the microsphere material is relatively large, and it cannot be confined to the required position as expected before the operation, and may be wrapped with the body to form granulation tissue; when complications occur after the operation, it is very difficult to remove the prosthesis , so its application is limited

Microsphere materials currently used for cosmetic plastic surgery include silica gel microspheres, agarosetran microspheres, polyvinyl alcohol porous microspheres, etc., but these materials have short-term or long-term inflammatory reactions, such as local low-grade inflammatory reactions (postoperative 2 weeks), wound repair reaction (4 weeks after operation) and chronic foreign body reaction (8 months after operation), and the fluidity is relatively large, and the fixation effect needs to be improved, so it is urgent to improve the performance of microsphere materials

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