Microsphere tissue engineering scaffold used in beauty filling, and preparation method of microsphere tissue engineering scaffold

A technology of tissue engineering scaffolds and microspheres, which is applied in tissue regeneration, coating, medical science, etc., can solve the problems that cannot be confined to the required position, the fluidity of the microsphere material is large, and the difficulty of taking out the prosthesis, so as to prevent escape. Dispersion, avoiding the formation of granulation tissue, wide application range

Inactive Publication Date: 2013-05-01
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the fluidity of the microsphere material is relatively large, and it cannot be confined to the required position as expected before the operation, and may be wrapped with the body to form granulation tissue; when complications occur after the operation, it is very difficult to remove the prosthesis , so its application is limited
Microsphere materials currently used for cosmetic plastic surgery include silica gel microspheres, agarosetran micr...

Method used

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  • Microsphere tissue engineering scaffold used in beauty filling, and preparation method of microsphere tissue engineering scaffold
  • Microsphere tissue engineering scaffold used in beauty filling, and preparation method of microsphere tissue engineering scaffold
  • Microsphere tissue engineering scaffold used in beauty filling, and preparation method of microsphere tissue engineering scaffold

Examples

Experimental program
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Effect test

Embodiment 1

[0046] In this example, the method of the present invention is used to prepare microsphere tissue engineering scaffolds for cosmetic filling, and the process steps are as follows:

[0047] (1) Preparation of polyurethane microspheres

[0048] ①Prepolymerization reaction

[0049] Add 0.27mol of isophorone diisocyanate and 0.15mol of polyε-caprolactone diol 2000 into a four-neck three-necked bottle equipped with a stirrer, thermometer, condenser, and nitrogen inlet and outlet pipes, and stir at a stirring speed of 1000r / min Under normal pressure, 75°C and under the protection of nitrogen, react for 2.5 hours, and pass condensed water into the condensation pipe during the reaction;

[0050] ② Chain extension reaction

[0051] At a stirring speed of 1000r / min, add 0.07mol of hydrophilic chain extender triethanolamine to the reaction solution formed in step ①, and lower its temperature to room temperature, then add 4 times the molar amount of isophorone diisocyanate Acetone and ...

Embodiment 2

[0060] In this example, the method of the present invention is used to prepare microsphere tissue engineering scaffolds for cosmetic filling, and the process steps are as follows:

[0061] (1) Preparation of polyurethane microspheres

[0062] ①Prepolymerization reaction

[0063] Add 0.26 mol of diphenylmethane diisocyanate and 0.19 mol of polyε-caprolactone diol 1000 into a four-neck three-neck flask equipped with a stirrer, a thermometer, a condenser tube, and a nitrogen inlet and outlet tube, at a stirring speed of 1000r / min Under normal pressure, 75°C and under the protection of nitrogen, react for 3.5 hours, and pass condensed water into the condensation pipe during the reaction;

[0064] ② Chain extension reaction

[0065] At a stirring speed of 1000r / min, add 0.02mol small molecule chain extender ethylene glycol and 0.03mol hydrophilic chain extender 2,2-dimethylolpropionic acid into the reaction solution formed in step ①, and mix them The temperature is lowered to ro...

Embodiment 3

[0074] In this example, the method of the present invention is used to prepare microsphere tissue engineering scaffolds for cosmetic filling, and the process steps are as follows:

[0075] (1) Preparation of polyurethane microspheres

[0076] ①Prepolymerization reaction

[0077] Add 0.27mol of isophorone diisocyanate and 0.15mol of polyε-caprolactone diol 2000 into a four-neck three-necked flask equipped with a stirrer, thermometer, condenser, and nitrogen inlet and outlet pipes, and stir at a stirring speed of 900r / min Under normal pressure, 70°C and under the protection of nitrogen, react for 3 hours, and pass condensed water into the condensation pipe during the reaction;

[0078] ② Chain extension reaction

[0079] At a stirring speed of 900r / min, add 0.07mol of hydrophilic chain extender 2,2-dimethylolpropionic acid to the reaction liquid formed in step ①, and lower its temperature to room temperature, then add isophorone Acetone that is 3 times the molar weight of dii...

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Abstract

The invention relates to a microsphere tissue engineering scaffold used in beauty filling, and a preparation method of the microsphere tissue engineering scaffold, and belongs to the field of tissue engineering scaffold materials. The method comprises the following processing steps: (1) preparing polyurethane microspheres: feeding isocyanate monomers and oligomer divalent alcohol into a reaction vessel, carrying out 1.5 to 3.5 h's reaction under 70 to 90 DEG C, feeding hydrophilic chain extender, viscosity modifier and catalyst, heating till the temperature is 45 to 55 DEG C, and carrying out reaction for 3 to 4 h; feeding the reaction liquid into salt forming agent solution in a high-speed stirring manner, shearing and emulsifying for 1 to 3.5 h, cleaning the microspheres with deionized water, and carrying out vacuum freeze drying; (2) preparing a polyurethane microsphere scaffold: dispersing the polyurethane microspheres in NaCl solution to form uniform emulsion, pouring the emulsion into a die, and carrying out freeze drying under -50 to -20 DEG C; and (3), conducting mineralization treatment on the surface of the scaffold: fixing the polyurethane microsphere scaffold in calcium-phosphorus supersaturated solution containing urease in a slowly stirring manner, carrying out mineralization treatment for 2 to 24 h, cleaning the scaffold for 2 to 24 h with deionized water, and carrying out freeze drying.

Description

technical field [0001] The invention belongs to the field of tissue engineering scaffold materials, in particular to a microsphere tissue engineering scaffold for cosmetic filling and a preparation method thereof. Background technique [0002] In recent years, microsphere materials have been widely used as filling materials for cosmetic injections. Because no incision is required during the operation, the operation is simple, the patient suffers less pain, and meets the needs of modern people for minimally invasive plastic surgery, so microsphere materials are widely used by patients once they are applied. welcome. However, the fluidity of the microsphere material is relatively large, and it cannot be confined to the required position as expected before the operation, and may be wrapped with the body to form granulation tissue; when complications occur after the operation, it is very difficult to remove the prosthesis , so its application is limited. Microsphere materials ...

Claims

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Application Information

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IPC IPC(8): C08J7/06C08L75/06C08L75/08C08G18/66C08G18/42C08G18/48C08G18/10A61L27/18A61L27/12
CPCC08G18/48C08L75/08C08J7/06C08G18/42A61L27/18C08G18/10A61L27/12C08L75/06C08G18/66A61L27/306A61L2430/34C08G18/0814C08G18/0823C08G18/3275C08G18/3278
Inventor 张利龚梅李玉宝解慧琪邹琴王妍媖
Owner SICHUAN UNIV
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