Piezoelectric polyether-ether-ketone composite material with antibacterial properties, and preparation method and application thereof

A technology of polyether ether ketone and composite materials, which is applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of elastic modulus mismatch, no biological activity, poor biocompatibility, etc., and achieve stable structure and size, Promotes cell adhesion and good biocompatibility

Inactive Publication Date: 2019-09-17
GUANGDONG UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Major diseases and accidents will cause irreparable damage to human bones, so it is necessary to replace or transplant new bones or external objects. Common bone substitutes have disadvantages such as poor biocompatibility, mismatching elastic modulus, and unstable size. , It is easy to cause problems such as normal bone degeneration, inflammation and sequelae such as secondary surgery
Polyether...

Method used

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  • Piezoelectric polyether-ether-ketone composite material with antibacterial properties, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Dry 10g of polyether ether ketone and 10g of sodium potassium lithium niobate powder at 120°C for 12 hours, mix them uniformly, and obtain a fibrous polyether ether ketone / sodium potassium lithium niobate composite material by melt co-extrusion method, wherein Melt co-extrusion chamber temperature 150°C, nozzle temperature 360°C;

[0026] 2. After the surface of the obtained polyetheretherketone / sodium potassium lithium niobate composite fiber material was treated by high-temperature plasma sputtering, it was soaked in 200mL1.5mol / L doxorubicin DMF solution for 3h, and the concentration was 95% Rinse three times with anhydrous ethanol, then wash three times with acetone solution, and dry in vacuum at 40°C to prepare a piezoelectric polyether ether ketone composite material with antibacterial properties.

[0027] The obtained piezoelectric PEEK composite material with antibacterial properties was subjected to ultraviolet sterilizing treatment, and cultured osteoblasts...

Embodiment 2

[0030] 1. Dry 5g of polyetheretherketone and 0.5g of lithium niobate powder at 150°C for 12 hours, mix them evenly, and obtain a fibrous polyetheretherketone / lithium niobate composite material through 3D printing technology, in which the melt co-extrusion cavity Chamber temperature 120°C, nozzle temperature 350°C;

[0031] 3. After the surface of the obtained polyetheretherketone / lithium niobate composite fiber material is treated with ultraviolet radiation, it is immersed in a dichloromethane solution of 150mL2.5mol / L quinolone for 4.5h, and the concentration is 95% without Rinse three times with water and ethanol, then wash three times with acetone solution, and vacuum-dry at 40°C to obtain a piezoelectric polyetheretherketone composite material with antibacterial properties.

[0032] The antibacterial piezoelectric polyetheretherketone composites obtained were subjected to ultraviolet sterilization treatment, and the osteoblasts were cultured in a 100Hz magnetic field envir...

Embodiment 3

[0034] 1. Dry 12g of polyetheretherketone and 1g of potassium niobate powder at 120°C for 24 hours, mix well, and obtain fibrous polyetheretherketone / potassium niobate composite material through in-situ rapid polymerization technology;

[0035] 2. After the surface of the obtained polyetheretherketone / potassium niobate composite fiber material is treated by magnetron sputtering, immerse it in 250mL1mol / L penicillin-phosphate buffer solution for 5h, and use 95% absolute ethanol Rinse three times, then wash three times with acetone solution, and vacuum-dry at 40°C to obtain a piezoelectric polyether ether ketone composite material with antibacterial properties.

[0036] The obtained antibacterial piezoelectric polyetheretherketone composite material was subjected to ultraviolet sterilization treatment, and cultured osteoblasts in the environment of 1.2V and 120Hz. Compared with untreated PEEK fibers, PEEK The elastic modulus of the composite material is 17.6GPa, which is similar...

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Abstract

The invention belongs to the technical field of biological tissue engineering, and discloses a piezoelectric polyether-ether-ketone composite material with antibacterial properties, and a preparation method and application thereof. The composite material is obtained by the following steps that: polyether-ether-ketone and niobate are blended after being dried, at a temperature of 350-450DEG C, a forming method is adopted to prepare polyether-ether-ketone/ niobate composite fiber material, and after the composite fiber material is processed and is dipped in solvent containing antibacterial medicines to be loaded, the obtained material is dried in vacuum at a temperature of 40-80DEG C. The polyether-ether-ketone composite material can accelerate the generation of calcium phosphorus salt on the surface of an implant, can accelerate bone cell proliferation and differentiation as well as cell adhesion under the function of an external electromagnetic field, and has the characteristics of no inflammation, no toxin, good biocompatibility, simple preparation method and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical tissue engineering, and more specifically relates to a piezoelectric polyetheretherketone composite material with antibacterial properties and its preparation method and application. Background technique [0002] Major diseases and accidents will cause irreparable damage to human bones, so it is necessary to replace or transplant new bones or external objects. Common bone substitutes have disadvantages such as poor biocompatibility, mismatching elastic modulus, and unstable size. , It is easy to cause problems such as normal bone degeneration, inflammation and sequelae such as secondary surgery. Polyetheretherketone (PEEK) as a biological material can meet the mechanical performance requirements of bone replacement materials such as strength and elastic modulus. However, PEEK is an inert and non-hydrophilic material. As a biological implant, it has no biological activity in the internal environ...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/54
CPCA61L27/446A61L27/54A61L2300/404A61L2300/606A61L2430/02C08L61/16
Inventor 闵永刚刘荣涛王勇刘屹东廖松义张诗洋庞贻宇肖天华
Owner GUANGDONG UNIV OF TECH
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