23 results about "Pyrylium salt" patented technology

The application provides a static spinning solution containing pyridinium propane sulfonate, a preparation method thereof and a static spinning method thereof. The static spinning solution comprises an additive pyridinium propane sulfonate, PAN polyacrylonitrile and DMF. Experiments prove that the static spinning solution has low cost, can improve the entanglement degree between molecular chains, inhibits the breakage of a solution jet in a static spinning process, and the micro-morphology is improved.

The invention relates to the technical field of biomedical detection and functional organic fluorescent materials, in particular to synthesis and application of a single-molecule probe combining BODIPY (boron dipyrromethene) and a semi-cyano dye. Comprising the following steps: preparing an intermediate 1: reacting 4-hydroxybenzaldehyde with 2, 4-dimethyl pyrrole to generate BDP-OMe, and then reacting with pyridinium chlorochromate to obtain the intermediate 1; preparation of an intermediate 2: carrying out reflux reaction on 2, 3, 3-trimethyl-3H-indole and 2-bromoethanol in ethanol to obtain the intermediate 2; and synthesizing a final product: heating the intermediate 1 and the intermediate 2 in toluene to react, and performing post-treatment and column chromatography purification to obtain the probe CyB-C. The bimodal detection capability enables the probe to simultaneously distinguish the microenvironment difference between normal cells and cancer cells and monitor diseases related to viscosity abnormity.

The application provides a monovalent ionic liquid fiber membrane, a preparation method and application in recovery of palladium, and belongs to the technical field of adsorbing materials, and comprises the following steps: mixing dichloromethane and acetic acid to obtain a first solution; dissolving cellulose acetate and ionic liquid in the first solution to obtain a second solution; the ionic liquid is any one of an alkenyl imidazole salt, a quaternary ammonium salt containing an alkenyl group, a quaternary phosphonium salt containing an alkenyl group, a pyridine salt containing an alkenyl group or a morpholine salt containing an alkenyl group; N,N'-methylene bisacrylamide and benzoyl peroxide are added into the second solution, heated, stirred and warmed to obtain a third solution, and the third solution is subjected to high-pressure electrospinning to obtain the monovalent ionic liquid fiber membrane; or the second solution is subjected to high-pressure electrospinning and then irradiation to obtain the monovalent ionic liquid fiber membrane. The monovalent ionic liquid fiber membrane prepared by the application can realize rapid adsorption and easy regeneration and desorption, and can efficiently and selectively adsorb and recover palladium from a complex acidic solution.

The invention discloses a preparation method of a deuterated pyridinium salt participated photo-induced bicyclo [1.1. 1] pentane derivative, which comprises the following steps: putting a compound shown in a formula 1 and a compound shown in a formula 2 into an organic solvent, and carrying out illumination reaction on the compound shown in the formula 1 and the compound shown in the formula 2 and a bicyclo [1.1. 1] pentane compound shown in a formula 3 in an alkaline environment to obtain the deuterated pyridinium salt fragment-containing bicyclo [1.1. 1] pentane derivative shown in a formula 4, the reaction process is as follows: a substituent R1 is selected from an ester group or substituted amide, a substituent R2 is selected from phenyl or substituted phenyl, and the substituent of the substituted phenyl is methyl, methoxyl, cyano, an ester group, phenyl, halogen, tertiary butyl, phenoxyl, trifluoromethoxyl or trifluoromethyl. The method has the advantages of mild reaction conditions, no need of a catalyst, complete reaction at room temperature, economy, practicability, environmental friendliness and no generation of harmful substances; the efficiency is high after reaction amplification.

This patent application discloses a benzophenone-modified triphenylamine pyridinium salt organic photosensitizer, its preparation method, and its application. This photosensitizer is a triphenylamine-based compound, specifically synthesized into four compounds: CHO-TPAP-BP, CHO-pTPAP-BP, CHO-eTPAP-BP, and 2CN-eTPAP-BP. This organic photosensitizer combines the strong electron-withdrawing ability of pyridinium salts with the electron-donating properties of triphenylamine, resulting in greater separation of the HOMO-LUMO orbitals in the molecule. This is beneficial for reducing ΔE. ST Secondly, by utilizing the strong intersystem crossing ability of benzophenone, orbital spin coupling (SOC) can be enhanced, thereby increasing the efficiency of reactive oxygen species production and thus improving the photodynamic therapy effect; furthermore, it is hoped that anthracene and singlet oxygen ( 1 The characteristics of O2 reaction to generate internal peroxides and controllable release of oxygen under thermal conditions alleviate hypoxia during photodynamic therapy; at the same time, the multi-rotor structure and the multiple rotations and vibrations of bonds in the molecules are conducive to the construction of a photothermal conversion platform, thereby realizing multimodal synergistic therapy of tumors.

The invention provides a method for preparing 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone, which comprises the following steps: by taking 1, 2-disubstituted pyrazol-3-ketone as an initial raw material, 1, 2-dichloroethane as a reaction solvent and pyridinium chlorochromate as an oxidizing agent, carrying out dehydroaromatization reaction on the 1, 2-disubstituted pyrazol-3-ketone to obtain the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone, and reacting the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone with 1, 2-dichloroethane to obtain the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone. The synthesis method comprises the following steps: preparing 1, 2-dihydro-3H-pyrazole-3-ketone. According to the present invention, the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazole-3-ketone can be prepared, the reaction conditions are mild, the process is simple, the yield of the product 1, 2-disubstituted 1, 2-dihydro-3H-pyrazole-3-ketone is high, and the method is suitable for industrial production.

Chemical compounds that include a pyridinium-based compound functionalized by including a sulfur-containing substituent are provided. Also provided are materials and formulations including such pyridinium-based compounds. Also provided are corrosion-resistant substrates and films including such pyridinium-based compounds. Also provided are processes for inhibiting corrosion of a metallic surface using the formulations and processes of acidizing a subsurface formation using the pyridinium-based compounds.

A process for inhibiting microbial growth comprising administering a formulation comprising a pyridinium chloride compound of Formula (I), described herein, wherein R1-R6, independently comprise hydrogen, substituted or unsubstituted C1 to C24 alkyl, substituted or unsubstituted alkylaryl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, sulfonate, aryl sulfonate, C1 to C24 alkyl sulfonate, taurine, carboxylate, amine, alkylamine, arylamine, alkylammonium, arylammonium, sulfonamide, halogen, hydroxy, amide, nitro, cyano, azide, O-alkyl, S-alkyl, silyl, trialkylsilyl, O-silyl, haloalkyl, alkylsulfhydryl, trifluoromethyl, hydrazide, substituted or unsubstituted aryl, heteroaryl, or heterocyclic alkynyl, carboxyalkyl, aminoalkyl, haloalkyl, azidoalkyl, amide, amino acid, or peptide; and X and Y independently comprise a heteroatom selected from oxygen, nitrogen, or sulfur, or a heterocarbyl comprising one or heteroatoms selected from oxygen, nitrogen, or sulfur.

The invention discloses a pyridinium fluorescent probe compound as well as a preparation method and application thereof in cell mitochondrial staining, and belongs to the technical field of biomedical detection. The compound is formed by combining a 5-cyano indanone derivative and pyridinium salt, and the synthesis method is simple. The compound Y1OPy has large Stokes shift and low cytotoxicity, can specifically target living cell mitochondria, presents clear mitochondrial network structure fluorescence imaging, and does not have specific targeting to fixed cells, and the probe is suitable for real-time, dynamic and high-resolution fluorescence imaging of living cell mitochondria, and has wide application prospects. The method has a wide application prospect in the field of biomedical research.

This invention discloses a pyran salt-catalyzed alcohol deoxygenation preparation method. 18 This invention relates to a method for labeling ketones with O, belonging to the field of organic synthesis technology. The process uses tertiary benzyl alcohol as a raw material and triphenylpyran salt as a catalyst, under visible light irradiation, with H2... 18 O is 18 O source, can be obtained in high yield 18 O-labeled ketones. This invention does not require acids or high temperatures, and avoids the residue of transition metals. It uses a novel, inexpensive organic photocatalyst to catalyze the oxidation of alcohols to ketones under mild reaction conditions. 18 O mark.

The application discloses an alkyl pyridine salt type aggregation-induced emission compound, a preparation method and application thereof, a molecular structural formula of the alkyl pyridine salt type aggregation-induced emission compound is as follows: the preparation method comprises the following steps: stirring and refluxing raw material D, 1,4-dimethyl pyridine-1-iodide, anhydrous ethanol and piperidine overnight, after the reaction mixture is cooled, vacuum concentration is carried out, and the crude product is purified by elution, so that the alkyl pyridine salt type aggregation-induced emission compound is obtained. The alkyl pyridine salt type aggregation-induced emission compound provided by the application can simultaneously and efficiently kill gram-positive bacteria and gram-negative bacteria.

The invention discloses a synthesis method of P-(1-ethoxyethoxy) styrene, which comprises the following steps: S1, reacting 4-acetoxystyrene with alkaline metal salt in an organic solvent system under the protection of inert gas, the reaction time in the S1 is 1-3 hours, the molar ratio of the 4-acetoxystyrene to the alkaline metal salt is 1: (2.2-2.8), and the reaction time in the S2 is 1-3 hours; adjusting the pH value of the reaction liquid, concentrating under reduced pressure, extracting and drying to obtain an intermediate p-hydroxystyrene; s2, in a mixed solvent system of dichloromethane containing a polymerization inhibitor and lower alcohol, p-hydroxystyrene and ethyl vinyl ether react under the catalytic action of pyridinium toluenesulfonate to obtain P-(1-ethyoxyl ethyoxyl) styrene; according to the present invention, the first step reaction is researched, the reaction condition is mild, the energy and the production cost are saved, the reaction time is short, the reaction process is simple, and the yield of the step is improved to be close to 100% so as to improve the total yield of the product.

The invention provides a degradation agent for target protein degradation and a preparation method thereof, and relates to the field of target protein degradation. The degradation agent for target protein degradation is prepared from the following components in parts by weight: 1 to 2 parts of ZDHHC20 ligand, 1 to 2 parts of E3 ligase ligand, 2 to 4 parts of linker, 0.8 to 1.2 parts of halogenated hydrocarbon, 0.8 to 1.5 parts of Lewis acid, 1 to 2 parts of pyridinium chlorochromate, 2 to 3 parts of acetonitrile, 0.6 to 0.8 part of primary alcohol, 2 to 3 parts of alkali and 1 to 2 parts of aromatic compound. According to the degradation agent for target protein degradation provided by the invention, the pyridinium chlorochromate, the aromatic compound and the halogenated hydrocarbon are combined for use, so that basic chemical modification and comprehensive coverage of characteristics of a final product can be realized, firstly, carboxyl with relatively high activity is introduced through the pyridinium chlorochromate; the preparation method comprises the following steps: firstly, preparing the ZDHHC20, then improving the stability and targeting ability of molecules through an aromatic compound, finally completing a key chemical bond forming step by virtue of halogenated hydrocarbon and lewis acid, and indirectly recovering the functions of the cancer suppressor proteins and promoting cancer cells to enter an apoptosis procedure by degrading the ZDHHC20 or adjusting the activity of the ZDHHC20.

A formulation for inhibiting metal corrosion includes a solution comprising a pyridine salt compound comprising a Formula (I), as described herein, dissolved in a non-aqueous solvent. A method of making a pyridinium salt-based solution comprises reacting a pyridine having Formula (II), described herein, or a salt thereof with an epoxide having a Formula (III), described herein, in the presence of an acid and a non-aqueous solvent.

A formulation for inhibiting metal corrosion includes a solution comprising a pyridine salt compound comprising a Formula (I), as described herein, dissolved in a non-aqueous solvent. A method of making a pyridinium salt-based solution comprises reacting a pyridine having Formula (II), described herein, or a salt thereof with an epoxide having a Formula (III), described herein, in the presence of an acid and a non-aqueous solvent.

The invention belongs to the field of photosensitizers, and relates to a photosensitizer of pyridinium fused benzothiadiazole as well as a preparation method and application of the photosensitizer. The photosensitizer is selected from a compound as shown in a formula I or pharmaceutically acceptable salt or ester or solvate, tautomer, stereoisomer, metabolite or prodrug, and the structure of the compound as shown in the formula I is shown in the specification. The photosensitizer has fluorescence emission from red light to near infrared light, can efficiently generate active oxygen, can be used as a fluorescent probe for accurate targeting of mitochondria in cells, and is applied to photodynamic-chemical synergistic treatment of tumor cells.

The application discloses a tetraphenyl ethene skeleton pyridine salt singlet oxygen type photosensitizer and application thereof in preparation of bacteriostatic agents, wherein the tetraphenyl ethene skeleton pyridine salt singlet oxygen type photosensitizer has a general structure as shown in the following formula (I): wherein X is selected from one of I ‑ , Br ‑ , Cl ‑ , F ‑ , OH ‑ , NO3 ‑ , SHO3 ‑ and PF6 ‑ ; R1 is selected from an aromatic ring derivative electron donor group; and R2 is selected from one of an alkyl group, an alkoxy group, a 4-boronic acid phenyl group and a 4-methyl benzene boronic acid pinacol ester. The photosensitizer combines AIE fluorescence enhancement characteristics and high ROS generation capacity, significantly improves bacteriostatic selectivity and bacteriostatic efficiency, and provides a new strategy for APDT treatment of bacterial infection.

The application discloses a photothermal agent for treating allergic rhinitis and application of the photothermal agent in preparation of allergic rhinitis drugs. 5000 The compound 2 is prepared by reacting the compound 1 with diethylene glycol-2-bromoethyl methyl ether, then the prepared compound 2 and DSPE-mPEG 5000 are dissolved in tetrahydrofuran to perform self-assembly and form nanoparticles, the nanoparticles have a red shift of an absorption wavelength due to a strong electron-withdrawing effect of the pyridine salt group, promote intramolecular charge transfer, have deeper tissue penetration ability, can effectively reach a deep part of a nasal mucosa and treat deep inflammation; the RH@NPs prepared by the application have high efficient photothermal conversion performance and sensitivity of photodynamic therapy, so that PTT and PDT can be used in synergistic treatment of allergic rhinitis, and the treatment effect is greatly improved, and a new way for treating allergic rhinitis is opened up.

The invention belongs to the technical field of additives for electroplating solutions, and particularly relates to a combined stress agent onset auxiliary agent and application thereof. The combined stress agent onset auxiliary agent is propane sulfonic acid pyridinium salt or a derivative thereof, and the propane sulfonic acid pyridinium salt derivative is characterized in that a pyridine ring contains at least one substituent group. The method is used for the palladium or palladium alloy bath-building electroplating liquid. According to the technical scheme provided by the invention, the stress of all samples produced after bath building of the plating solution can be always maintained within-20Mpa to 20Mpa by adding a small amount of the effective auxiliary agent, so that the process requirements are met; the palladium-cobalt ratio, the hardness, the modulus and the morphology of the plating layer are not changed; and the service life of the plating solution is not shortened and is still about 1.5 MTO, so that the plating solution is stable.

A process for inhibiting microbial growth comprising administering a formulation comprising a pyridinium chloride compound of Formula (I), described herein, wherein R1- R6, independently comprise hydrogen, substituted or unsubstituted C1 to C24 alkyl, substituted or unsubstituted alkylaryl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, sulfonate, aryl sulfonate, C1 to C24 alkyl sulfonate, taurine, carboxylate, amine, alkylamine, arylamine, alkylammonium, arylammonium, sulfonamide, halogen, hydroxy, amide, nitro, cyano, azide, O-alkyl, S-alkyl, silyl, trialkylsilyl, O-silyl, haloalkyl, alkylsulfhydryl, trifluoromethyl, hydrazide, substituted or unsubstituted aryl, heteroaryl, or heterocyclic alkynyl, carboxyalkyl, aminoalkyl, haloalkyl, azidoalkyl, amide, amino acid, or peptide; and X and Y independently comprise a heteroatom selected from oxygen, nitrogen, or sulfur, or a heterocarbyl comprising one or heteroatoms selected from oxygen, nitrogen, or sulfur.

This invention discloses a hypochlorous acid and hydrogen peroxide dual-response fluorescent probe compound based on a phenothiazine skeleton, its synthesis method, and its applications. The probe is prepared by nucleophilic addition reaction of phenothiazine with pyridinium salt of 4-cyanomethylphenylboronic acid, using phenothiazine as the core skeleton. The probe exhibits high sensitivity and selectivity for hypochlorous acid and hydrogen peroxide, with detection limits of 0.04 μM and 0.13 μM, respectively. The fluorescence emission wavelength difference between the two response channels reaches 220 nm, enabling simultaneous detection through both channels. This probe can monitor changes in endogenous and exogenous hypochlorous acid and hydrogen peroxide levels in living cells in real time and in situ, and has been successfully applied to the detection of biological processes such as ferroptosis, drug-induced liver injury, and oxidative stress. Furthermore, this probe can also be used for the quantitative detection of hypochlorous acid and hydrogen peroxide content in food and water samples, showing broad application prospects in the fields of biosensing, disease diagnosis, and food safety testing.

The present invention relates to a method for producing a compound [C] of the general formula [C] by subjecting a compound [A] having a hydroxyl group or a primary or secondary amino group and a compound [B] having a phosphorous atom-containing substituent group of the general formula [1] to a condensation reaction, characterized in that the method is carried out in the presence of at least one reaction accelerator selected from the group consisting of a quaternary ammonium salt, a quaternary imidazolium salt, a quaternary morpholinium salt, a quaternary phosphonium salt, a quaternary piperidinium salt, a quaternary pyridinium salt, a quaternary pyrrolidinium salt and a quaternary sulfonium salt.

The application relates to a liquid crystal material constructed based on cation-pi interaction and a preparation method and application thereof, first, a styrylpyridine carrying an alkyl tail chain is synthesized, and a corresponding styrylpyridine salt is obtained through a simple methylation reaction, then the cation-pi interaction between the head-to-tail alternating benzene rings and the pyridine salt cations is used to orderly assemble columnar liquid crystal materials. The double cation-pi interaction between adjacent liquid crystal molecules effectively enhances the orderly assembly capacity between the liquid crystal units, thereby widening the temperature interval of the liquid crystal material and improving the stability of the liquid crystal material. The preparation method of the supramolecular liquid crystal material based on the cation-pi interaction not only widens the force category of the supramolecular liquid crystal material, but also provides a new strategy for the preparation of the supramolecular liquid crystal material; in addition, the prepared liquid crystal material based on the cation-pi interaction has great application prospects in the fields of information storage, photoelectric materials and the like due to the high molecular order.