42 results about "Pyrylium salt" patented technology

Provided is a cosmetic containing ascorbic acid and / or a salt thereof, which has excellent stability and reduced irritation to the skin. The cosmetic according to the present invention contains ascorbic acid and / or a salt thereof, ultrapure water, and an antioxidant, and the salt of ascorbic acid is at least one selected from the group consisting of a trimethylamine salt, a triethylamine salt, a monoethanolamine salt, a triethanolamine salt, a pyridinium salt, an arginine salt, an ammonium salt, a sodium salt, a potassium salt, a calcium salt, a magnesium salt, and an aluminum salt of ascorbic acid. The antioxidant is glutathione or sodium pyrosulfite, the pH of the cosmetic material is adjusted to 5.0-7.0, and the dissolved oxygen content of the cosmetic material is 0-5 mg / L.

The present application relates to the field of macromolecular compounds connected to the polymer of styrene or alkyl-substituted styrene, in particular to a LED-sensitive ketoxime ester type water-soluble photoinitiator based on styryl pyridine salt and its manufacturing method and application. The LED-sensitive ketoxime ester type water-soluble photoinitiator based on styryl pyridine salt is characterized in that: a styryl group is connected to a pyridine ring to form a diaryl ethylene structure, and a ketoxime ester is connected to the para position of the double bond on the benzene ring. The manufacturing method of the LED-sensitive ketoxime ester type water-soluble photoinitiator based on styryl pyridine salt is characterized in that: the reaction is carried out according to the reaction formula (a), (b), (c) and (d) in sequence. The present application has good light absorption performance and good matching with LED light source.

The application provides a static spinning solution containing pyridinium propane sulfonate, a preparation method thereof and a static spinning method thereof. The static spinning solution comprises an additive pyridinium propane sulfonate, PAN polyacrylonitrile and DMF. Experiments prove that the static spinning solution has low cost, can improve the entanglement degree between molecular chains, inhibits the breakage of a solution jet in a static spinning process, and the micro-morphology is improved.

The invention relates to the technical field of biomedical detection and functional organic fluorescent materials, in particular to synthesis and application of a single-molecule probe combining BODIPY (boron dipyrromethene) and a semi-cyano dye. Comprising the following steps: preparing an intermediate 1: reacting 4-hydroxybenzaldehyde with 2, 4-dimethyl pyrrole to generate BDP-OMe, and then reacting with pyridinium chlorochromate to obtain the intermediate 1; preparation of an intermediate 2: carrying out reflux reaction on 2, 3, 3-trimethyl-3H-indole and 2-bromoethanol in ethanol to obtain the intermediate 2; and synthesizing a final product: heating the intermediate 1 and the intermediate 2 in toluene to react, and performing post-treatment and column chromatography purification to obtain the probe CyB-C. The bimodal detection capability enables the probe to simultaneously distinguish the microenvironment difference between normal cells and cancer cells and monitor diseases related to viscosity abnormity.

The present application relates to a kind of hypochlorite detection probe based on pyridine salt and preparation method thereof.The fluorescence probe structure is as shown in formula I.The fluorescent molecular probe of the present application is prepared from o-alkynyl aldehyde as raw material, by condensation reaction with pyridine salt.The probe synthesis method is simple, and the reaction condition is mild, and the yield of target compound is high.The fluorescent molecular probe described in the present application has stable optical performance, high sensitivity for hypochlorite detection, low detection lower limit, detection limit is 0.38 μM, response range is 5-200 μM.It has good selectivity, and has no response to fluoride ion, iodine ion, perchlorate ion, bisulfate ion, sulfate ion, acetate ion, thiocyanate ion, sulfur ion, etc.The fluorescent molecular probe described in the present application has practical application value in the field of biochemistry and environmental chemistry, especially the detection of hypochlorite ion in water, etc.

The invention discloses a fireproof flame-retardant fiber and a preparation method thereof, and relates to the technical field of fibers. When the fireproof and flame-retardant fiber is prepared, luteolin and 3-chloro-1-propylene are subjected to a reaction, and modified luteolin is prepared; the modified luteolin and zinc acetate are subjected to a reaction, and a luteolin complex is prepared; the preparation method comprises the following steps: reacting pyridinium salt dimethyl pimelate, dimethyl terephthalate, 1, 6-hexanediol and dihydroxy DOPO (9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide) to obtain copolyester; acrylic acid is polymerized and coated on the surface of magnesium hydroxide to prepare modified magnesium hydroxide; and uniformly mixing the modified magnesium hydroxide, a luteolin complex and copolyester, carrying out melt spinning, and treating with azodiisobutyronitrile to obtain the fireproof flame-retardant fiber. The fireproof flame-retardant fiber prepared by the invention has excellent flame retardance, antibacterial property and mechanical strength.

The invention provides a high-voltage quick charge binder and a preparation method thereof, positive electrode slurry, a positive electrode plate and a battery, and relates to the field of binders. The high-voltage quick charge binder comprises poly (4-cyano-2-butenoic acid N-cyano-2-trifluoropropyl pyridinium salt), and a binding agent, the structural formula of the poly (4-cyano-2-butenoic acid N-cyano-2-trifluoropropyl pyridinium salt) is shown in the specification. The high-voltage quick charge binder can effectively improve the voltage window of the binder, so that the stability of a high-voltage positive electrode system is improved.

The application provides a monovalent ionic liquid fiber membrane, a preparation method and application in recovery of palladium, and belongs to the technical field of adsorbing materials, and comprises the following steps: mixing dichloromethane and acetic acid to obtain a first solution; dissolving cellulose acetate and ionic liquid in the first solution to obtain a second solution; the ionic liquid is any one of an alkenyl imidazole salt, a quaternary ammonium salt containing an alkenyl group, a quaternary phosphonium salt containing an alkenyl group, a pyridine salt containing an alkenyl group or a morpholine salt containing an alkenyl group; N,N'-methylene bisacrylamide and benzoyl peroxide are added into the second solution, heated, stirred and warmed to obtain a third solution, and the third solution is subjected to high-pressure electrospinning to obtain the monovalent ionic liquid fiber membrane; or the second solution is subjected to high-pressure electrospinning and then irradiation to obtain the monovalent ionic liquid fiber membrane. The monovalent ionic liquid fiber membrane prepared by the application can realize rapid adsorption and easy regeneration and desorption, and can efficiently and selectively adsorb and recover palladium from a complex acidic solution.

The application provides a light conversion agent, a preparation method and application thereof, and a light conversion film, and belongs to the technical field of chemical synthesis. The light conversion agent is an organic salt ion-rare earth Eu (III) anion type, is an ion pair type light conversion agent, has absorption of organic and inorganic complexes, has stronger ultraviolet absorption capacity, and is synthesized by introducing an electron-donating group N,N-dimethyl into a para position of a pyridine nitrogen and introducing a bromohexyl group to form a corresponding electron-withdrawing pyridine group to synthesize a pyridine salt, and is synthesized by taking 2-thiophene formyl trifluoroacetylacetone as a ligand to synthesize a rare earth anion complex Eu (HTTA) 4 ‑ By ion exchange, bromine ions in the pyridine salt are replaced by the complex anions, and by electrostatic interaction between the pyridine cation and the anion complex, sensitization of rare earth luminescence is realized, and the ultraviolet absorption capacity is improved. Moreover, the light conversion agent has a long alkyl flexible chain, can be better blended with LLDPE, and enhances the stability and dispersibility of the light conversion agent in resin.

The invention relates to an epsilon-alkyl alpha, beta-gamma, delta-diunsaturated ester compound, and belongs to the field of organic synthesis, the epsilon-alkyl alpha, beta-gamma, delta-diunsaturated ester compound has the following structural general formula: the compound structurally has multiple reaction sites, and has wide application in multiple fields due to reaction activity and structural diversity; a series of epsilon-alkyl alpha, beta-gamma, delta-diunsaturated ester compounds can be prepared by taking gamma-functionalized olefine aldehyde and pyridinium salt as starting raw materials under the synergistic catalysis of light and carbene, and a target compound can be subjected to certain chemical conversion; the compound can be used for synthesizing complex natural products, drug intermediates and the like as a dienophile in the fields of organic synthesis and fine chemical engineering. Besides, the substance also has wide application prospects in the aspects of polymer science and materials, and can be used as a comonomer to be used in the fields of coatings, adhesives, hydrogels and the like.

The invention discloses a preparation method of a deuterated pyridinium salt participated photo-induced bicyclo [1.1. 1] pentane derivative, which comprises the following steps: putting a compound shown in a formula 1 and a compound shown in a formula 2 into an organic solvent, and carrying out illumination reaction on the compound shown in the formula 1 and the compound shown in the formula 2 and a bicyclo [1.1. 1] pentane compound shown in a formula 3 in an alkaline environment to obtain the deuterated pyridinium salt fragment-containing bicyclo [1.1. 1] pentane derivative shown in a formula 4, the reaction process is as follows: a substituent R1 is selected from an ester group or substituted amide, a substituent R2 is selected from phenyl or substituted phenyl, and the substituent of the substituted phenyl is methyl, methoxyl, cyano, an ester group, phenyl, halogen, tertiary butyl, phenoxyl, trifluoromethoxyl or trifluoromethyl. The method has the advantages of mild reaction conditions, no need of a catalyst, complete reaction at room temperature, economy, practicability, environmental friendliness and no generation of harmful substances; the efficiency is high after reaction amplification.

This patent application discloses a benzophenone-modified triphenylamine pyridinium salt organic photosensitizer, its preparation method, and its application. This photosensitizer is a triphenylamine-based compound, specifically synthesized into four compounds: CHO-TPAP-BP, CHO-pTPAP-BP, CHO-eTPAP-BP, and 2CN-eTPAP-BP. This organic photosensitizer combines the strong electron-withdrawing ability of pyridinium salts with the electron-donating properties of triphenylamine, resulting in greater separation of the HOMO-LUMO orbitals in the molecule. This is beneficial for reducing ΔE. ST Secondly, by utilizing the strong intersystem crossing ability of benzophenone, orbital spin coupling (SOC) can be enhanced, thereby increasing the efficiency of reactive oxygen species production and thus improving the photodynamic therapy effect; furthermore, it is hoped that anthracene and singlet oxygen ( 1 The characteristics of O2 reaction to generate internal peroxides and controllable release of oxygen under thermal conditions alleviate hypoxia during photodynamic therapy; at the same time, the multi-rotor structure and the multiple rotations and vibrations of bonds in the molecules are conducive to the construction of a photothermal conversion platform, thereby realizing multimodal synergistic therapy of tumors.

The invention provides a method for preparing 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone, which comprises the following steps: by taking 1, 2-disubstituted pyrazol-3-ketone as an initial raw material, 1, 2-dichloroethane as a reaction solvent and pyridinium chlorochromate as an oxidizing agent, carrying out dehydroaromatization reaction on the 1, 2-disubstituted pyrazol-3-ketone to obtain the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone, and reacting the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone with 1, 2-dichloroethane to obtain the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazol-3-ketone. The synthesis method comprises the following steps: preparing 1, 2-dihydro-3H-pyrazole-3-ketone. According to the present invention, the 1, 2-disubstituted 1, 2-dihydro-3H-pyrazole-3-ketone can be prepared, the reaction conditions are mild, the process is simple, the yield of the product 1, 2-disubstituted 1, 2-dihydro-3H-pyrazole-3-ketone is high, and the method is suitable for industrial production.

Chemical compounds that include a pyridinium-based compound functionalized by including a sulfur-containing substituent are provided. Also provided are materials and formulations including such pyridinium-based compounds. Also provided are corrosion-resistant substrates and films including such pyridinium-based compounds. Also provided are processes for inhibiting corrosion of a metallic surface using the formulations and processes of acidizing a subsurface formation using the pyridinium-based compounds.

A process for inhibiting microbial growth comprising administering a formulation comprising a pyridinium chloride compound of Formula (I), described herein, wherein R1-R6, independently comprise hydrogen, substituted or unsubstituted C1 to C24 alkyl, substituted or unsubstituted alkylaryl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, sulfonate, aryl sulfonate, C1 to C24 alkyl sulfonate, taurine, carboxylate, amine, alkylamine, arylamine, alkylammonium, arylammonium, sulfonamide, halogen, hydroxy, amide, nitro, cyano, azide, O-alkyl, S-alkyl, silyl, trialkylsilyl, O-silyl, haloalkyl, alkylsulfhydryl, trifluoromethyl, hydrazide, substituted or unsubstituted aryl, heteroaryl, or heterocyclic alkynyl, carboxyalkyl, aminoalkyl, haloalkyl, azidoalkyl, amide, amino acid, or peptide; and X and Y independently comprise a heteroatom selected from oxygen, nitrogen, or sulfur, or a heterocarbyl comprising one or heteroatoms selected from oxygen, nitrogen, or sulfur.

The invention discloses a pyridinium fluorescent probe compound as well as a preparation method and application thereof in cell mitochondrial staining, and belongs to the technical field of biomedical detection. The compound is formed by combining a 5-cyano indanone derivative and pyridinium salt, and the synthesis method is simple. The compound Y1OPy has large Stokes shift and low cytotoxicity, can specifically target living cell mitochondria, presents clear mitochondrial network structure fluorescence imaging, and does not have specific targeting to fixed cells, and the probe is suitable for real-time, dynamic and high-resolution fluorescence imaging of living cell mitochondria, and has wide application prospects. The method has a wide application prospect in the field of biomedical research.

This invention discloses a pyran salt-catalyzed alcohol deoxygenation preparation method. 18 This invention relates to a method for labeling ketones with O, belonging to the field of organic synthesis technology. The process uses tertiary benzyl alcohol as a raw material and triphenylpyran salt as a catalyst, under visible light irradiation, with H2... 18 O is 18 O source, can be obtained in high yield 18 O-labeled ketones. This invention does not require acids or high temperatures, and avoids the residue of transition metals. It uses a novel, inexpensive organic photocatalyst to catalyze the oxidation of alcohols to ketones under mild reaction conditions. 18 O mark.

The application discloses an alkyl pyridine salt type aggregation-induced emission compound, a preparation method and application thereof, a molecular structural formula of the alkyl pyridine salt type aggregation-induced emission compound is as follows: the preparation method comprises the following steps: stirring and refluxing raw material D, 1,4-dimethyl pyridine-1-iodide, anhydrous ethanol and piperidine overnight, after the reaction mixture is cooled, vacuum concentration is carried out, and the crude product is purified by elution, so that the alkyl pyridine salt type aggregation-induced emission compound is obtained. The alkyl pyridine salt type aggregation-induced emission compound provided by the application can simultaneously and efficiently kill gram-positive bacteria and gram-negative bacteria.

The invention discloses a synthesis method of P-(1-ethoxyethoxy) styrene, which comprises the following steps: S1, reacting 4-acetoxystyrene with alkaline metal salt in an organic solvent system under the protection of inert gas, the reaction time in the S1 is 1-3 hours, the molar ratio of the 4-acetoxystyrene to the alkaline metal salt is 1: (2.2-2.8), and the reaction time in the S2 is 1-3 hours; adjusting the pH value of the reaction liquid, concentrating under reduced pressure, extracting and drying to obtain an intermediate p-hydroxystyrene; s2, in a mixed solvent system of dichloromethane containing a polymerization inhibitor and lower alcohol, p-hydroxystyrene and ethyl vinyl ether react under the catalytic action of pyridinium toluenesulfonate to obtain P-(1-ethyoxyl ethyoxyl) styrene; according to the present invention, the first step reaction is researched, the reaction condition is mild, the energy and the production cost are saved, the reaction time is short, the reaction process is simple, and the yield of the step is improved to be close to 100% so as to improve the total yield of the product.

The application discloses a kind of chitosan double pyridyl group acid-resistant adsorbents and its preparation method and application, belong to electroplating sludge processing technical field.The application selects chitosan as matrix, and carries out amine group and pyridyl group grafting on its basis, and the adsorbent containing amine group and pyridyl group is prepared, the problem that the hydroxyl group and amine group on chitosan body are protonated in acidic solution and the ability of chelating metal cation is poor is solved, and heavy metal in acidic solution cannot be effectively separated.The substitution reaction of amine group and the reagent 2-chloromethyl pyridine hydrochloride (2-CPD) with lower price is used in the application, compared with existing M4195 commercial resin, production cost is reduced, and it is suitable for wide range of popularization and application.

The invention provides a degradation agent for target protein degradation and a preparation method thereof, and relates to the field of target protein degradation. The degradation agent for target protein degradation is prepared from the following components in parts by weight: 1 to 2 parts of ZDHHC20 ligand, 1 to 2 parts of E3 ligase ligand, 2 to 4 parts of linker, 0.8 to 1.2 parts of halogenated hydrocarbon, 0.8 to 1.5 parts of Lewis acid, 1 to 2 parts of pyridinium chlorochromate, 2 to 3 parts of acetonitrile, 0.6 to 0.8 part of primary alcohol, 2 to 3 parts of alkali and 1 to 2 parts of aromatic compound. According to the degradation agent for target protein degradation provided by the invention, the pyridinium chlorochromate, the aromatic compound and the halogenated hydrocarbon are combined for use, so that basic chemical modification and comprehensive coverage of characteristics of a final product can be realized, firstly, carboxyl with relatively high activity is introduced through the pyridinium chlorochromate; the preparation method comprises the following steps: firstly, preparing the ZDHHC20, then improving the stability and targeting ability of molecules through an aromatic compound, finally completing a key chemical bond forming step by virtue of halogenated hydrocarbon and lewis acid, and indirectly recovering the functions of the cancer suppressor proteins and promoting cancer cells to enter an apoptosis procedure by degrading the ZDHHC20 or adjusting the activity of the ZDHHC20.

The invention discloses a polypeptide or protein modification method for photopromoting cysteine desulfurization, which comprises the following steps: by taking a naked peptide containing cysteine or a protein containing solvent-exposed cysteine as a raw material, taking a free radical receptor as another raw material, taking pyridinium as an activating reagent, taking a buffer solution as a reaction solvent, and carrying out photolysis reaction to obtain the polypeptide or protein. In the presence of a reducing agent and an additive and under the irradiation of visible light, cysteine desulfurization of polypeptide or protein is realized to form a stereoscopically retained C-X bond, and the free radical receptor is any one of electron-deficient olefin, acrylamide, acrylate, an organic selenium compound, 2, 2, 6, 6-tetramethylpiperidine-N-oxygen free radical or N-heterouracil. The invention relates to a method for constructing a C-X bond, which is promoted by visible light, stereoscopically retains a modification site and is compatible with a disulfide bond under a biocompatible condition, and can be used for site selective accurate modification of polypeptide and protein.

The application provides a salt-responsive porous composite material and a preparation method and application thereof. The porous composite material is obtained by combining pyridine salt positive ions in a rigid polymer and carboxylate negative ions of a polyurethane polymer through electrostatic interaction. The porous composite material not only has the structural stability of a rigid adsorption material, but also has the salt response performance and high adsorption performance of a flexible adsorption material, and the like, and realizes efficient adsorption of oil in a water environment. The salt-responsive porous composite material has an adsorption capacity of n-hexane of more than 10 g / g, and can be up to 49.3 g / g.

A formulation for inhibiting metal corrosion includes a solution comprising a pyridine salt compound comprising a Formula (I), as described herein, dissolved in a non-aqueous solvent. A method of making a pyridinium salt-based solution comprises reacting a pyridine having Formula (II), described herein, or a salt thereof with an epoxide having a Formula (III), described herein, in the presence of an acid and a non-aqueous solvent.

A formulation for inhibiting metal corrosion includes a solution comprising a pyridine salt compound comprising a Formula (I), as described herein, dissolved in a non-aqueous solvent. A method of making a pyridinium salt-based solution comprises reacting a pyridine having Formula (II), described herein, or a salt thereof with an epoxide having a Formula (III), described herein, in the presence of an acid and a non-aqueous solvent.

The invention belongs to the field of photosensitizers, and relates to a photosensitizer of pyridinium fused benzothiadiazole as well as a preparation method and application of the photosensitizer. The photosensitizer is selected from a compound as shown in a formula I or pharmaceutically acceptable salt or ester or solvate, tautomer, stereoisomer, metabolite or prodrug, and the structure of the compound as shown in the formula I is shown in the specification. The photosensitizer has fluorescence emission from red light to near infrared light, can efficiently generate active oxygen, can be used as a fluorescent probe for accurate targeting of mitochondria in cells, and is applied to photodynamic-chemical synergistic treatment of tumor cells.

The application discloses a tetraphenyl ethene skeleton pyridine salt singlet oxygen type photosensitizer and application thereof in preparation of bacteriostatic agents, wherein the tetraphenyl ethene skeleton pyridine salt singlet oxygen type photosensitizer has a general structure as shown in the following formula (I): wherein X is selected from one of I ‑ , Br ‑ , Cl ‑ , F ‑ , OH ‑ , NO3 ‑ , SHO3 ‑ and PF6 ‑ ; R1 is selected from an aromatic ring derivative electron donor group; and R2 is selected from one of an alkyl group, an alkoxy group, a 4-boronic acid phenyl group and a 4-methyl benzene boronic acid pinacol ester. The photosensitizer combines AIE fluorescence enhancement characteristics and high ROS generation capacity, significantly improves bacteriostatic selectivity and bacteriostatic efficiency, and provides a new strategy for APDT treatment of bacterial infection.

The application discloses a photothermal agent for treating allergic rhinitis and application of the photothermal agent in preparation of allergic rhinitis drugs. 5000 The compound 2 is prepared by reacting the compound 1 with diethylene glycol-2-bromoethyl methyl ether, then the prepared compound 2 and DSPE-mPEG 5000 are dissolved in tetrahydrofuran to perform self-assembly and form nanoparticles, the nanoparticles have a red shift of an absorption wavelength due to a strong electron-withdrawing effect of the pyridine salt group, promote intramolecular charge transfer, have deeper tissue penetration ability, can effectively reach a deep part of a nasal mucosa and treat deep inflammation; the RH@NPs prepared by the application have high efficient photothermal conversion performance and sensitivity of photodynamic therapy, so that PTT and PDT can be used in synergistic treatment of allergic rhinitis, and the treatment effect is greatly improved, and a new way for treating allergic rhinitis is opened up.

The invention discloses a naphthalimide skeleton pyridinium salt two-photon fluorescent material and application thereof. The structural general formula of the naphthalimide skeleton pyridinium salt two-photon fluorescent material is shown in the specification. The naphthalimide skeleton pyridine salt two-photon fluorescent material disclosed by the invention has a function of developing a plurality of subcellular organelles of cancer cells. Compared with a single-photon fluorescent material, the fluorescent material has the characteristics of low excitation energy, long wavelength, strong penetrability, small light damage, low toxicity and the like, so that the fluorescent material has no damage to normal cells, can be used for cancer cell detection, and has obvious application value.

The invention belongs to the technical field of additives for electroplating solutions, and particularly relates to a combined stress agent onset auxiliary agent and application thereof. The combined stress agent onset auxiliary agent is propane sulfonic acid pyridinium salt or a derivative thereof, and the propane sulfonic acid pyridinium salt derivative is characterized in that a pyridine ring contains at least one substituent group. The method is used for the palladium or palladium alloy bath-building electroplating liquid. According to the technical scheme provided by the invention, the stress of all samples produced after bath building of the plating solution can be always maintained within-20Mpa to 20Mpa by adding a small amount of the effective auxiliary agent, so that the process requirements are met; the palladium-cobalt ratio, the hardness, the modulus and the morphology of the plating layer are not changed; and the service life of the plating solution is not shortened and is still about 1.5 MTO, so that the plating solution is stable.