5 results about "Isosorbide dinitrate" patented technology

This invention relates to an isosorbide dinitrate pharmaceutical composition injection and its preparation method. In addition to isosorbide dinitrate, the injection formulation also contains meglumine and glutathione. The preferred specifications are 5ml:5mg and 10ml:10mg. The isosorbide dinitrate injection prepared according to the formulation and process of this invention has the characteristics of high excipient safety, simple process, extremely high quality stability and good safety, which is significantly better than the prior art.

The present invention discloses a high-conductivity composite coating diaphragm, its preparation method, and application. The high-conductivity composite coating diaphragm comprises: a base film and a coating coated on the base film. The coating comprises: poly(p-phenylene terephthalamide), lithium aluminum titanium phosphate, aluminum nitride, and a first substance, the first substance being one or a mixture of lithium nitrate, sodium dodecylbenzenesulfonate, an organic nitrate, and isosorbide dinitrate. The present invention improves the transport of lithium ions in the coating diaphragm by introducing aluminum nitride, thereby improving the ionic conductivity of the coating diaphragm. The introduction of PPTA further enhances the heat resistance and adhesion of the coating diaphragm. The introduction of LATP provides the coating diaphragm with good porosity, thermal stability, and liquid absorption rate. The first substance is introduced as a dispersant for LATP, improving its dispersibility. Furthermore, the inclusion of lithium in the first substance replenishes lithium in the diaphragm, synergizing with aluminum nitride to enhance the ionic conductivity of the diaphragm.

The invention provides a pharmaceutical composition for relieving vasospasm and a preparation method and application thereof.The pharmaceutical composition is prepared from main functional components including fasudil and isosorbide dinitrate, the concentration of fasudil is 10-3.5 mol / L, the concentration of isosorbide dinitrate is 10-4 mol / L, the concentration of isosorbide dinitrate is 10-15 mol / L, and the concentration of isosorbide dinitrate is 10-15 mol / L; the preparation method comprises the following steps: weighing the fasasdil hydrochloride and the isosorbide dinitrate according to the formula amount, and respectively adding the fasasdil hydrochloride and the isosorbide dinitrate into the Ringer's solution. The fasudil and the isosorbide dinitrate with specific concentration in the pharmaceutical composition have synergistic effects, so that the effects of relieving vasospasm and relaxing blood vessels can be quickly achieved, and the final relaxation degree is increased, which not only has direct significance in clinical prevention and treatment of vasospasm, but also has good clinical application prospects. And the traditional Chinese medicine composition also has a good effect on the middle and long-term patency rate of postoperative blood vessels.

The invention discloses an isosorbide dinitrate sustained-release tablet and a preparation method thereof, sodium alginate is used as a sustained-release skeleton, lactose, calcium hydrophosphate and dextrin are used as filling agents, and the hydrophilicity of lactose is beneficial for water to rapidly permeate into the tablet to start medicine dissolution; the hydrophobic and rigid structure of the calcium hydrophosphate hinders rapid penetration of water and drug diffusion; partial dissolvability of dextrin can form local corrosion or channels; through combination of multiple aspects, the permeation rate and diffusion path of moisture and the corrosion / expansion degree of a tablet matrix can be adjusted, a more controllable and more stable drug release environment is constructed together, and the sustained release requirement is met.

The invention relates to the technical field of drug analysis and detection, and particularly discloses a method for detecting related substances in an isosorbide mononitrate sodium chloride injection and application of the method. The invention provides a method for detecting related substances in an isosorbide mononitrate sodium chloride injection. The method comprises the following steps: preparing a mixed reference solution, preparing a test solution and carrying out liquid chromatography detection, wherein the liquid chromatography detection adopts a mobile phase gradient elution procedure, a mobile phase A is methanol-water, and a mobile phase B is ethanol-trimethylpentane; furthermore, the volume ratio of methanol to water in the mobile phase A is (25-30): (70-75), and the volume ratio of ethanol to trimethylpentane in the mobile phase B is (15-20): (80-85). According to the detection method provided by the invention, the contents of isosorbide mononitrate, 2-isosorbide mononitrate and isosorbide dinitrate in the isosorbide mononitrate sodium chloride injection can be rapidly and accurately detected, and the detection sensitivity and accuracy are high.