3 results about "Isosorbide dinitrate" patented technology

This invention relates to an isosorbide dinitrate pharmaceutical composition injection and its preparation method. In addition to isosorbide dinitrate, the injection formulation also contains meglumine and glutathione. The preferred specifications are 5ml:5mg and 10ml:10mg. The isosorbide dinitrate injection prepared according to the formulation and process of this invention has the characteristics of high excipient safety, simple process, extremely high quality stability and good safety, which is significantly better than the prior art.

The present invention discloses a high-conductivity composite coating diaphragm, its preparation method, and application. The high-conductivity composite coating diaphragm comprises: a base film and a coating coated on the base film. The coating comprises: poly(p-phenylene terephthalamide), lithium aluminum titanium phosphate, aluminum nitride, and a first substance, the first substance being one or a mixture of lithium nitrate, sodium dodecylbenzenesulfonate, an organic nitrate, and isosorbide dinitrate. The present invention improves the transport of lithium ions in the coating diaphragm by introducing aluminum nitride, thereby improving the ionic conductivity of the coating diaphragm. The introduction of PPTA further enhances the heat resistance and adhesion of the coating diaphragm. The introduction of LATP provides the coating diaphragm with good porosity, thermal stability, and liquid absorption rate. The first substance is introduced as a dispersant for LATP, improving its dispersibility. Furthermore, the inclusion of lithium in the first substance replenishes lithium in the diaphragm, synergizing with aluminum nitride to enhance the ionic conductivity of the diaphragm.

The invention discloses an isosorbide dinitrate sustained-release tablet and a preparation method thereof, sodium alginate is used as a sustained-release skeleton, lactose, calcium hydrophosphate and dextrin are used as filling agents, and the hydrophilicity of lactose is beneficial for water to rapidly permeate into the tablet to start medicine dissolution; the hydrophobic and rigid structure of the calcium hydrophosphate hinders rapid penetration of water and drug diffusion; partial dissolvability of dextrin can form local corrosion or channels; through combination of multiple aspects, the permeation rate and diffusion path of moisture and the corrosion / expansion degree of a tablet matrix can be adjusted, a more controllable and more stable drug release environment is constructed together, and the sustained release requirement is met.