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Polymethyl polyglycol methacrylate containing sorbitol ester mononitrate structure as well as preparation method and use method thereof

The technology of polymethyl polyethylene glycol acrylate and methyl polyethylene glycol acrylate is applied in the field of polymethyl polyethylene glycol acrylate and its preparation, and can solve the problems of complicated preparation methods and achieve analgesia. good effect

Inactive Publication Date: 2012-02-08
TIANJIN PLASTICS RES INST CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its preparation method is cumbersome

Method used

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  • Polymethyl polyglycol methacrylate containing sorbitol ester mononitrate structure as well as preparation method and use method thereof
  • Polymethyl polyglycol methacrylate containing sorbitol ester mononitrate structure as well as preparation method and use method thereof
  • Polymethyl polyglycol methacrylate containing sorbitol ester mononitrate structure as well as preparation method and use method thereof

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Embodiment Construction

[0033] Below in conjunction with accompanying drawing and specific embodiment the present invention is described in further detail:

[0034]The monomer containing isosorbide mononitrate structure in the present invention is 2-acrylic acid-5-isosorbide nitrate; the methyl polyethylene glycol acrylate and its derivatives are methyl polyethylene glycol acrylate And its derivatives with various substituents added to the acryloyl structure; the molecular weight of the methyl polyethylene glycol in the methyl polyethylene glycol acrylate and its derivatives is 1000-5000; the acrylic acid Methyl esters and their analogues are various derivatives containing acrylate structures, various derivatives containing sodium vinylsulfonate (vinylsulfonamide) structures, and 2-methacryloyloxyethyl phosphorylcholine ; The free radical initiator is Cl 2 、Br 2 , Organic peroxides (such as cyclohexanone peroxide, dibenzoyl peroxide, tert-butyl hydroperoxide, etc.), azo initiators (such as azobisis...

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Abstract

The invention discloses a polymethyl polyglycol methacrylate containing an isosorbide sorbitol ester structure as well as a preparation method and a use method thereof. The preparation method comprises the following steps of: mixing 2-acrylic acid-5-isosorbide dinitrate, methyl acrylate compounds and methylpropenoic polyglycol acid ester compounds; polymerizing free groups under the protection of nitrogen gas; reacting at the temperature of 20-90DEG C for 1-20 hours; repeatedly precipitating and dissolving generated polymerisate by petroleum ether and tetrahydrofuran; and finally, vacuum drying. The obtained polymer has a certain analgesic function and a better anticoagulation effect.

Description

technical field [0001] The present invention relates to polymethylpolyethylene glycol acrylate and its preparation method and application method, in particular polymethylpolyethylene glycol acrylic acid containing sorbitol mononitrate structure used for anticoagulation on the surface of polymers Esters and methods of making and using the same. Background technique [0002] In recent years, the research on the blood compatibility of the surface of biomedical materials used in contact with blood has attracted people's attention and has become a research hotspot. Blood-compatibility means that the material does not cause denaturation of plasma proteins, does not destroy the active ingredients of blood, does not cause blood coagulation and thrombus formation after contact with blood. As early as the 1960s, it was discovered that when biomaterials are implanted into the body and come into contact with blood, protein molecules will be adsorbed on the surface of the material, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/14C08F220/28C08F220/36C08J5/18A61L33/06
Inventor 武衡张明艳王翔曹雪陈雪赵俊龙李秀丽王竹林
Owner TIANJIN PLASTICS RES INST CO LTD
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