Preparation method of high-adhesion analgesic hydrogel microneedle patch and microneedle patch

A technology of hydrogel and microneedle sticking, which is applied in the direction of microneedles, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of adhesion dependence, low drug bioavailability, and diseased parts. allergies etc.

Pending Publication Date: 2022-05-06
THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this adhesion only brings the drug closer to the target site, but the drug cannot completely fit the site, resulting in low bioavailability of the immobilized drug.
On the other h

Method used

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  • Preparation method of high-adhesion analgesic hydrogel microneedle patch and microneedle patch
  • Preparation method of high-adhesion analgesic hydrogel microneedle patch and microneedle patch
  • Preparation method of high-adhesion analgesic hydrogel microneedle patch and microneedle patch

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preparation example Construction

[0028] see figure 1 and image 3 , the present invention provides a method for preparing a highly adhesive analgesic hydrogel microneedle patch. Described preparation method comprises:

[0029] Step S101, mixing the hydrogel material, the initiator of the crosslinked polymer and the initiator of the crosslinked polymer to prepare a prepolymer.

[0030] Wherein, the hydrogel material is a cross-linked polymer of acrylamide and dopamine. Among them, acrylamide is used as a raw material for organic synthesis and as a raw material for polymer materials. Its polymers are usually soluble in water, especially for the flocculation of protein and starch in water. It has excellent properties such as flocculation, thickening, shear resistance, drag reduction, and dispersibility. Dopamine is a neurotransmitter, a chemical used to help cells send impulses. Polydopamine molecules are formed by the oxidative self-polymerization of dopamine molecules.

[0031] Preferably, the crosslink...

Embodiment 1

[0046] 1) 2 ml of acrylamide, 0.05 g of N,N-methylenebisacrylamide and 0.05 g of ammonium peroxide were uniformly mixed in ice water to form a prepolymer;

[0047] 2) After that, drop the above-mentioned mixed prepolymer into the prepared PDMS mold and carry out vacuum treatment to ensure that the prepolymer is completely filled with the mould;

[0048] 3) Transfer the above mold to an oven at 37°C, and remove the film after 2 hours to obtain a polydopamine-doped polyacrylamide hydrogel microneedle patch with high adhesion;

[0049] 4) Rinse the above-mentioned hydrogel microneedle patch with water for 3 times, cool to a ventilated place and wait for the liquid to evaporate gradually; then immerse the microneedle part of the hydrogel microneedle patch into 0.1 ml of 20% lidocaine hydrochloride Caine solution for 3 hours, take it out and cool it to a ventilated place until the drug gradually penetrates;

[0050] After repeated three times, the lidocaine-loaded polydopamine-dop...

Embodiment 2

[0052] 1) 2 milliliters of acrylamide, 0.02 gram of bupivacaine hydrochloride, 0.05 gram of N, N-methylenebisacrylamide and 0.05 gram of ammonium peroxide are uniformly mixed in ice water to form a prepolymer;

[0053] 2) Drop the above-mentioned prepolymer into the prepared PDMS mold and perform vacuum treatment on it to ensure that the prepolymer is completely filled with the mold;

[0054] 3) Transfer the above-mentioned mold to an oven at 37°C, remove the film after 2 hours, soak the obtained hydrogel patch repeatedly with ultrapure water to elute the bupivacaine molecules in the colloid, and obtain the bupivacaine-containing Molecularly imprinted highly adhesive polyacrylamide hydrogel microneedle patch;

[0055] 4) After rinsing the above-mentioned hydrogel microneedle patch with water for 3 times, use a pipette gun to pipette 0.1 ml of bupivacaine hydrochloride solution with a mass fraction of 20%, and evenly drop-coat it on the surface with bupivacaine molecular imprin...

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Abstract

The invention discloses a preparation method of a high-adhesion analgesic hydrogel microneedle patch, which comprises the following steps: mixing a hydrogel material, an initiator of a cross-linked polymer and an initiator of the cross-linked polymer to prepare a prepolymer; filling a PDMS mold with the prepolymer, and carrying out vacuum treatment on the PDMS mold; putting the PDMS mold into a drying oven, and demolding after 2 hours, so as to obtain the hydrogel microneedle patch; and carrying out analgesic drug loading on the hydrogel microneedle patch to obtain the high-adhesion analgesic hydrogel microneedle patch. The high-adhesion analgesic hydrogel microneedle patch comprises a high-adhesion hydrogel material and an analgesic drug. The high-adhesion hydrogel material is a copolymer of polydopamine and hydrogel. The high-adhesion analgesic hydrogel microneedle patch can release analgesic drugs through swelling of hydrogel in a body. In the process, the adhesion performance of the polydopamine can enable the polydopamine to be firmly attached to the acting part, and the analgesic effect is efficiently and accurately achieved.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, in particular to a preparation method of a high-adhesion analgesic hydrogel microneedle patch and the microneedle patch. Background technique [0002] Pain is one of the most common clinical symptoms. At present, more and more pains are caused by cancer, bone and joint degenerative diseases, neuromuscular diseases, etc. According to the survey and statistics of the Chinese Medical Disease Prevention and Control Committee: Among the 2,000 samples, the incidence rate of pain is 12%; among the 30-40 years old, the patients account for 59.1%; among the 50-60 years old, the patients account for 81%; The incidence of pain in the population is as high as 82%. Taking the morbidity rate of 12% as an example, if the population of the city is 1 million, the number of patients will be as many as 120,000. In densely aging cities, assuming that there are 400,000 50-60-year-old population among the...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/167A61K31/445A61K31/485A61K47/32A61K47/34A61P29/00A61M37/00
CPCA61K9/7023A61K9/0021A61K31/167A61K31/445A61K31/485A61K47/32A61K47/34A61P29/00A61M37/0015A61M2037/0053A61M2037/0046
Inventor 纪木火刘盼苗杨建军
Owner THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIV
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