31results about How to "Harsh reaction conditions" patented technology

The invention discloses a method for producing diglycolamidic acid, namely, the key intermediate synthesized by glyphosate through biological catalysis and a new strain used in the process. The method takes iminodiacetonitrile as a raw material and a microbial enzyme with nitrilase activity obtained from the fermentation culture of Alcaligenes faecalis ZJUTB10 as a catalyst and obtains the diglycolamidic acid as a product by going through hydrolysis reaction under certain condition. The beneficial effects of the method are mainly reflected by little waste water produced during the reaction process, little pollution, mild reaction conditions, low energy consumption, high conversion rate and high yield and being easy for industrialized production.

The invention is a method for co-liquefaction of coal and waste plastics under a mild condition, which comprises the following steps: adding coal, waste plastics, lignosulfonate, a catalyst, and a solvent into an autoclave, introducing hydrogen to increase the pressure to 1.0-10.0 Mpa, heating to 300-450 DEG C for a liquefaction reaction, collecting the gas after the hydrogenation liquefaction test in the autoclave, analyzing the gas phase composition by a gas chromatography, collecting all the other liquefaction products in a filter paper cylinder, performing hexane and tetrahydrofuran solvent extraction in order by a soxhlet extraction device, wherein the substance soluble in hexane is oil, and the substances soluble in tetrahydrofuran but insoluble in hexane are asphaltene and preasphaltene, and calculating the total conversion rate of the liquefaction by using the amount of the insoluble substances in tetrahydrofuran. The invention allows the coal to perform a depolymerization reaction at a low temperature, and to be co-liquefied with waste plastics; the extraction rate of coal by solvents such as pyridine and the like is increased, and the coal liquefaction process is accelerated; not only the hydrogen consumption and production cost for coal liquefaction are greatly reduced, but also white pollution caused by waste plastics is solved.

The invention discloses a method for efficiently dehalogenating waste plastics. The method comprises the following three steps: 1. quenching and tempering: adding an alkaline chemical raw material to the waste plastics, then adding a solution of a Ni<2+> chemical raw material / waste material and stirring and uniformly mixing the materials; 2. hydrothermal treatment: carrying out hydrothermal treatment on the prepared waste plastics at 200-240 DEG C for 10-60 minutes; 3. dehydration: carrying out solid-liquid separation on a mixture obtained after hydrothermal treatment, thus obtaining coke. The method has the beneficial effects that the function of Ni<2+> in plastic dehalogenation is confirmed for the first time; the method has the characteristics that the adding proportion of the alkaline chemical raw material is extremely small; the cost is low; the process is simple; the halogen removal efficiency is high; the reaction temperature is low; the time is short; the halogen containing rate of the waste plastics is reduced to about 0 from 56.8-74%; secondary pollution can not be caused; the plastics excluding halogen and some chemical raw materials after separation can be recycled, thus avoiding the problems of chlorine corrosion and dioxin pollution during halogen-containing plastic burning and providing beneficial conditions for harmless treatment and recycling of the halogen-containing plastics.

The invention discloses a method for preparing a chiral α-aryl carbonyl compound, comprising: R 2 The substituted iodobenzene diacetate compound was activated with Lewis acid and then reacted with R 3 Stereo-substituted oxazoline compounds react in the presence of a base to obtain the chiral α-aryl carbonyl compound; the R 1 R 2 selected from H, alkyl, substituted alkyl, wherein the substituent is selected from cycloalkyl, halogen, alkoxy, heterocycloalkyl, substituted heterocycloalkyl, aryl, cyano, aryloxy, carbonyl; R 3 Selected from alkyl, substituted alkyl, aryl. The method has mild reaction conditions, good stereoselectivity, easy separation of products and simple operation.

The invention relates to a preparation method of deacetylceftiamidine, which is suitable for pharmaceutical enterprises, and discloses step (1): dissolving cefathiamidine in water or water containing 5% to 20% organic solvent, and controlling the temperature to 20°C ~35°C, add 0.8~1.2 times of immobilized acetyl esterase, add pH regulator to control system pH7.0~9.0 at the same time, stir and react; the amount of water or water containing organic solvent is 2.5~ 4.0 times; step (2): after the reaction, filter, adjust the pH to 5.0-5.5, concentrate under reduced pressure, wash, filter, and vacuum-dry to obtain deacetylceftiamidine as a solid. The invention adopts an enzymatic method to prepare deacetylceftiamidine with a high purity of not less than 97%, and can be used as a reference substance for the quality control of cefathiamidine bulk drug and its preparation.

The present invention relates to the preparation method of antiangina drug isosorbide mononitrate (1,4:3,6-dianhydro-D-sorbitol-5-nitrate), comprising the following steps: i) using fuming nitric acid and 0~ 0.5-fold concentrated sulfuric acid directly nitrates isosorbide (3) to obtain isosorbide 2,5-dinitrate (4); then, ii) uses ruthenium (II) complex to catalyze hydrogenation to selectively reduce the 2-nitro group. The method has simple steps and high yield.

The invention discloses a 1,3-bis-(2,4,6-trimethylphenyl)-imidazole nitrogen-heterocyclic carbene catalyzed aryl ethyl ketene and N A new method for the synthesis of 3-ethyl-5-hydroxy-1,3-diarylindolone through the reaction of -aryliminoquinone. An imidazole nitrogen heterocyclic carbene catalyst is used to efficiently catalyze the [2+2] cycloaddition reaction. The resulting four-membered ring product is efficiently aromatized by a catalytic amount of Lewis acid to obtain aromatized indolinone. products. The method of the invention has the advantages of mild conditions, simple operation, green efficiency and high atom utilization rate.

The invention relates to a preparation process of a betamethasone intermediate. The structural formula of the betamethasone intermediate is shown as a formula I, and is prepared by undergoing a ketone group protection reaction, a Grignard reaction and a hydrolysis deprotection reaction on a compound III; and the ketone group protection reaction comprises making a compound II, diazanyl carboxylic ether and an acid react to obtain a compound IV. The method has high yield, and contributes to protecting the environment; and the use of toxic substances is avoided. The structural formula of the compound III is shown as a formula III.

The invention discloses a preparing method for taltirelin and a midbody of taltirelin. The preparing method comprises the steps that L-aspartic acid-4-methyl ester or other hydrochloride serves as raw materials, a compound A-5 is obtained through ammonolysis, carboxyl protection and cyclization, the compound A-5 and a compound B are simultaneously subjected to deprotection through a one-pot reaction under the acid condition, and 1-methyl-L-4,5-dihydro orotic acid (a compound A) and a compound C are obtained. The compound A and the compound C can be used for a next-step condensation reaction through separation or without separation, and taltirelin shown in the formula I is prepared through the condensation reaction. According to the technical scheme, the prepared compound A and compound C or taltirelin has the advantages that the utilization rate of the raw materials is high, operation changes gradually, the preparation steps are few, the reaction condition is mild, the requirement for production equipment is low, the yield is high, and cost is low.

The invention provides a preparation method of cyclopentyl phenyl ketone.The preparation method includes hydrolyzing 2-cyclopentyl benzoylacetate as a raw material in basic solvents to obtain a product, namely the cyclopentyl phenyl ketone, wherein the 2-cyclopentyl benzoylacetate is 2-cyclopentyl methyl benzoylacetate or 2-cyclopentyl ethyl benzoylacetate.The preparation method of the cyclopentyl phenyl ketone has the advantages of environment-friendly solvents, little environmental pollution, easiness in operation, high yield, short technological period and low preparation cost.