Single nitrate isosorbide sodium chloride injection

A technology of isosorbide dinitrate and sodium chloride injection, which is applied in the field of medicine, can solve the problems of reducing the curative effect, and achieve the effects of good curative effect, rapid and reliable action, disease remission and control

Inactive Publication Date: 2005-10-12
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the dosage forms of isosorbide mononitrate include tablets, capsules, etc. After oral administration, the blood drug concentration rises rapidly to 400ng / ml, which greatly exceeds the minimum effective dose (100ng / ml), causing patients to experience severe headaches, Nausea, vomiting, circulatory collapse and other side effects have an incidence rate of about 14%, and when taken for a long time, tolerance often occurs and the curative effect is reduced

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Isosorbide Mononitrate 15g

[0019] Sodium chloride 850g

[0020] Appropriate amount of water for injection

[0021] Preparation process: Dissolve isosorbide mononitrate and sodium chloride in an appropriate amount of water for injection, add activated carbon for injection, heat and boil for 10 minutes, filter; add water for injection to the full amount, and finally fill and sterilize to make 1000 bottles. Instantly.

Embodiment 2

[0023] Isosorbide Mononitrate 18g

[0024] Sodium chloride 868g

[0025] Appropriate amount of water for injection

[0026] The preparation process is the same as in Example 1.

Embodiment 3

[0028] Isosorbide Mononitrate 27g

[0029] Sodium chloride 905g

[0030] Appropriate amount of water for injection

[0031] The preparation process is the same as in Example 1.

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PUM

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Abstract

A liquid sodium chloride injection of isosorbide mononitrate for treating coronary heart disease and angina pectoris is prepared from isosorbide mononitrate and sodium chloride. It can quickly take its high curative effect.

Description

technical field [0001] The invention relates to an injection, in particular to an isosorbide mononitrate sodium chloride injection for treating coronary heart disease and angina pectoris, and belongs to the field of medicine. Background technique [0002] Isosorbide mononitrate is a commonly used drug for treating coronary heart disease and angina pectoris. It was first developed by Boehringer Mannheim GmbH in Germany and launched in the market in 1981. It has been clinically used for many years and has a definite curative effect. Its main mechanism of action is to expand venous volume vessels and peripheral resistance vessels, reduce cardiac preload and postload, and reduce myocardial oxygen consumption. The drug has the characteristics of high bioavailability, small individual differences, long half-life, and remarkable curative effect, and is better than indigestion and nitroglycerin in the prevention of coronary heart disease and angina pectoris....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/34A61P9/10
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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