Single nitrate isosorbide sodium chloride injection

Abstract

A liquid sodium chloride injection of isosorbide mononitrate for treating coronary heart disease and angina pectoris is prepared from isosorbide mononitrate and sodium chloride. It can quickly take its high curative effect.

Description

technical field [0001] The invention relates to an injection, in particular to an isosorbide mononitrate sodium chloride injection for treating coronary heart disease and angina pectoris, and belongs to the field of medicine. Background technique [0002] Isosorbide mononitrate is a commonly used drug for treating coronary heart disease and angina pectoris. It was first developed by Boehringer Mannheim GmbH in Germany and launched in the market in 1981. It has been clinically used for many years and has a definite curative effect. Its main mechanism of action is to expand venous volume vessels and peripheral resistance vessels, reduce cardiac preload and postload, and reduce myocardial oxygen consumption. The drug has the characteristics of high bioavailability, small individual differences, long half-life, and remarkable curative effect, and is better than indigestion and nitroglycerin in the prevention of coronary heart disease and angina pectoris....

AI Technical Summary

Problems solved by technology

[0003] At present, the dosage forms of isosorbide mononitrate include tablets, capsules, etc. After oral administration, the blood drug concentration rises rapidly to 400ng / ml, which greatly exceeds the minimum effective dose (100ng / ml), causing patients to experience severe headaches, Nausea, vomiting, circulatory collapse and other side effects have an incidence rate of about 14%, and when taken for a long time, tolerance often occurs and the curative effect is reduced