Isosorbide mononitrate sodium chloride injection

A technology of isosorbide dinitrate and sodium chloride injection, applied in the direction of active ingredients of heterocyclic compounds, medical preparations of non-active ingredients, cardiovascular system diseases, etc., can solve the problem of reduced curative effect, low bioavailability, and uncomfortable patients and other issues to achieve the effect of ensuring product safety, simple treatment of three wastes, and avoiding secondary pollution

Active Publication Date: 2010-05-19
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral preparations such as tablets, dripping pills, and capsules of isosorbide mononitrate are taken orally, and the blood drug concentration rises rapidly to 400ng/ml, which greatly exceeds the minimum effective dose (100ng/ml), causing patients to experience severe headaches, Nausea, vomiting, circulatory collapse and other side effects have an incidence rate of about 14%, and when taken for a long time, tolerance often occurs and the curative effect is reduced
[0005] Although isosorbide mononitrate aqueous injection overcomes the shortcomings of oral preparations such as slow drug effect, low bioavailability, and is not suitable for patients who cannot be administered orally, it needs to be added to sodium chloride injection or glucose injection for use. It brings operational troubles and the possibil...

Method used

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  • Isosorbide mononitrate sodium chloride injection
  • Isosorbide mononitrate sodium chloride injection
  • Isosorbide mononitrate sodium chloride injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Isosorbide Mononitrate 10mg

[0028] Sodium chloride 450mg

[0029] 0.05mol / L sodium hydroxide solution appropriate amount

[0030] Add water for injection to 100ml

[0031] Preparation process: first prepare the concentrated sodium chloride solution and filter it, add isosorbide mononitrate and stir to dissolve, add water for injection to the full amount, adjust the pH of the liquid to 4.3 with an appropriate amount of 0.05mol / L sodium hydroxide solution, and fill it out Bacteria, that is.

Embodiment 2

[0033] Isosorbide Mononitrate 20mg

[0034] Sodium chloride 900mg

[0035] 0.05mol / L sodium hydroxide solution appropriate amount

[0036] Add water for injection to 100ml

[0037] Preparation process: first prepare the concentrated sodium chloride solution and filter it, add isosorbide mononitrate and stir to dissolve, add water for injection to the full amount, adjust the pH value of the liquid to 5.7 with an appropriate amount of 0.05mol / L sodium hydroxide solution, and fill it out Bacteria, that is.

Embodiment 3

[0039] Isosorbide Mononitrate 20mg

[0040] Sodium chloride 900mg

[0041] 0.1mol / L sodium hydroxide solution appropriate amount

[0042] Add water for injection to 100ml

[0043] Preparation process: First prepare the concentrated sodium chloride solution and filter it, add isosorbide mononitrate and stir to dissolve, add water for injection to the full amount, adjust the pH of the liquid to 6.2 with an appropriate amount of 0.1mol / L sodium hydroxide solution, and fill it out Bacteria, that is.

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Abstract

The invention relates to isosorbide mononitrate sodium chloride injection which belongs to the field of medical preparation. The isosorbide mononitrate sodium chloride injection is prepared from 10-40mg of isosorbide mononitrate, 450-1800mg of sodium chloride, an amount of pH regulator which regulates the pH to 4.0-7.0 and water for injection, wherein the volume of the water for injection is fixed to 100ml. The isosorbide mononitrate sodium chloride injection has high stability and simple preparation process.

Description

technical field [0001] The invention relates to an injection of isosorbide mononitrate and sodium chloride, which belongs to the field of pharmaceutical preparations. Background technique [0002] Isosorbide mononitrate is a commonly used drug for the treatment of coronary heart disease and angina pectoris. It was first developed by BoehringerMannheim GmbH in Germany and launched in the market in 1981. It has been clinically used for many years and has a definite curative effect. Its main mechanism of action is to expand venous volume vessels and peripheral resistance vessels, reduce cardiac preload and postload, and reduce myocardial oxygen consumption. The drug has the characteristics of high bioavailability, small individual differences, long half-life, and remarkable curative effect, and is better than indigestion and nitroglycerin in the prevention of coronary heart disease and angina pectoris. [0003] Recent studies have shown that the crown-expanding effect of isoso...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/34A61K47/02A61K47/10A61P9/10
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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