Compound isosorbide mononitrate aspirin sustained-release capsule preparation and preparation method
A technology of isosorbide dinitrate and aspirin, which is applied to pharmaceutical formulations, medical preparations containing active ingredients, active ingredients of heterocyclic compounds, etc., can solve the problems of poor drug release reproducibility, slow initial drug release, and large individual differences.
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Embodiment 2
[0057] Embodiment 2, compound recipe isosorbide mononitrate aspirin sustained-release capsule preparation, produces 1000 capsules
[0058] Ball core prescription:
[0059]
[0060] ER gown prescription:
[0061] Ethylcellulose N100 30g
[0062] Povidone K30 5g
[0063] Ethanol 1000ml
[0064] Film Coating Prescription:
[0065] Opadry Gastric Coating Powder 12g
[0066] water 88g
[0067] Prescription of aspirin enteric-coated granules:
[0068] Aspirin 75g
[0069] Enteric coating prescription:
[0070]
Embodiment 3
[0071] Embodiment 3, compound recipe isosorbide mononitrate aspirin sustained-release capsule preparation, produces 1000 capsules
[0072] Ball core prescription:
[0073]
[0074] ER gown prescription:
[0075] Ethylcellulose N100 30g
[0076] Povidone K30 6g
[0077] Ethanol 1000ml
[0078] Film Coating Prescription:
[0079] Opadry Gastric Coating Powder 12g
[0080] water 88g
[0081] Prescription of aspirin enteric-coated granules:
[0082] Aspirin 75g
[0083] Enteric coating prescription:
[0084]
[0085] The compound recipe isosorbide mononitrate capsule preparation described in above embodiment 1, embodiment 2, embodiment 3 is made by following method:
[0086] Step 1, preparation of isosorbide mononitrate slow-release preparation:
[0087] 1.1, the preparation of 1% sodium carboxymethyl cellulose 10% ethanol solution: take the sodium carboxymethyl cellulose of prescription quantity and disperse evenly in 10% ethanol of prescription quantity, then add...
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